PMC:7128678 / 0-692 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":79,"end":90},"obj":"Chemical"},{"id":"4","span":{"begin":95,"end":113},"obj":"Chemical"},{"id":"5","span":{"begin":122,"end":142},"obj":"Disease"},{"id":"8","span":{"begin":190,"end":200},"obj":"Species"},{"id":"9","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"12","span":{"begin":305,"end":315},"obj":"Species"},{"id":"13","span":{"begin":268,"end":279},"obj":"Chemical"},{"id":"15","span":{"begin":374,"end":385},"obj":"Chemical"},{"id":"17","span":{"begin":417,"end":428},"obj":"Chemical"},{"id":"20","span":{"begin":444,"end":462},"obj":"Chemical"},{"id":"21","span":{"begin":483,"end":494},"obj":"Chemical"},{"id":"53","span":{"begin":551,"end":569},"obj":"Species"},{"id":"54","span":{"begin":571,"end":581},"obj":"Species"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D002738"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D006886"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:C000657245"},{"id":"A8","pred":"tao:has_database_id","subj":"8","obj":"Tax:2697049"},{"id":"A9","pred":"tao:has_database_id","subj":"9","obj":"MESH:C000657245"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"Tax:2697049"},{"id":"A13","pred":"tao:has_database_id","subj":"13","obj":"MESH:D002738"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"MESH:D002738"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"MESH:D002738"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:D006886"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D002738"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1","span":{"begin":79,"end":90},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T2","span":{"begin":95,"end":113},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T3","span":{"begin":122,"end":132},"obj":"SP_7"},{"id":"T4","span":{"begin":162,"end":170},"obj":"SP_7"},{"id":"T5","span":{"begin":190,"end":200},"obj":"SP_7"},{"id":"T6","span":{"begin":268,"end":279},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T7","span":{"begin":305,"end":315},"obj":"SP_7"},{"id":"T8","span":{"begin":374,"end":385},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T9","span":{"begin":417,"end":428},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T10","span":{"begin":444,"end":462},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T11","span":{"begin":483,"end":494},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T20","span":{"begin":551,"end":555},"obj":"SP_10"},{"id":"T21","span":{"begin":556,"end":567},"obj":"NCBITaxon:11118"},{"id":"T22","span":{"begin":571,"end":581},"obj":"SP_7"},{"id":"T23","span":{"begin":659,"end":663},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T9852","span":{"begin":79,"end":90},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T52976","span":{"begin":95,"end":113},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T69326","span":{"begin":122,"end":132},"obj":"SP_7"},{"id":"T83793","span":{"begin":162,"end":170},"obj":"SP_7"},{"id":"T92919","span":{"begin":190,"end":200},"obj":"SP_7"},{"id":"T46435","span":{"begin":268,"end":279},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T12850","span":{"begin":305,"end":315},"obj":"SP_7"},{"id":"T44469","span":{"begin":374,"end":385},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T22649","span":{"begin":417,"end":428},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T16393","span":{"begin":444,"end":462},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T69104","span":{"begin":483,"end":494},"obj":"CHEBI:3638;DG_10;CHEBI:3638"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T2","span":{"begin":133,"end":142},"obj":"Disease"},{"id":"T3","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"T4","span":{"begin":190,"end":194},"obj":"Disease"},{"id":"T5","span":{"begin":305,"end":309},"obj":"Disease"},{"id":"T6","span":{"begin":551,"end":567},"obj":"Disease"},{"id":"T7","span":{"begin":571,"end":579},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":50,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":207,"end":208},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":602,"end":603},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":79,"end":90},"obj":"Chemical"},{"id":"T2","span":{"begin":95,"end":113},"obj":"Chemical"},{"id":"T3","span":{"begin":268,"end":279},"obj":"Chemical"},{"id":"T4","span":{"begin":350,"end":359},"obj":"Chemical"},{"id":"T5","span":{"begin":374,"end":385},"obj":"Chemical"},{"id":"T6","span":{"begin":417,"end":428},"obj":"Chemical"},{"id":"T7","span":{"begin":483,"end":494},"obj":"Chemical"},{"id":"T8","span":{"begin":659,"end":663},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":142},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":154},"obj":"Sentence"},{"id":"T3","span":{"begin":155,"end":233},"obj":"Sentence"},{"id":"T4","span":{"begin":234,"end":316},"obj":"Sentence"},{"id":"T5","span":{"begin":317,"end":386},"obj":"Sentence"},{"id":"T6","span":{"begin":387,"end":440},"obj":"Sentence"},{"id":"T7","span":{"begin":441,"end":495},"obj":"Sentence"},{"id":"T8","span":{"begin":497,"end":505},"obj":"Sentence"},{"id":"T9","span":{"begin":506,"end":623},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection\n\nHighlights\n• The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.\n• Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.\n• In-silico studies confirm the antiviral properties of chloroquine.\n• New mechanism of action of chloroquine elucidated.\n• Hydroxychloroquine is more potent than chloroquine.\n\nAbstract\nThe recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re"}