Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

Highlights
•  The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.
•  Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2.
•  In-silico studies confirm the antiviral properties of chloroquine.
•  New mechanism of action of chloroquine elucidated.
•  Hydroxychloroquine is more potent than chloroquine.

Abstract
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most re