PMC:7127386 / 17445-18221 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"573","span":{"begin":78,"end":88},"obj":"Species"},{"id":"574","span":{"begin":31,"end":41},"obj":"Chemical"},{"id":"575","span":{"begin":46,"end":69},"obj":"Chemical"},{"id":"576","span":{"begin":157,"end":167},"obj":"Chemical"},{"id":"577","span":{"begin":182,"end":189},"obj":"Chemical"},{"id":"578","span":{"begin":453,"end":463},"obj":"Chemical"},{"id":"579","span":{"begin":531,"end":541},"obj":"Chemical"},{"id":"580","span":{"begin":546,"end":553},"obj":"Chemical"},{"id":"581","span":{"begin":211,"end":213},"obj":"CellLine"}],"attributes":[{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Tax:2697049"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"MESH:C000606551"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"MESH:D004640"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"MESH:C000606551"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:D004640"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"MESH:C000606551"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"MESH:C000606551"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"MESH:D004640"},{"id":"A581","pred":"tao:has_database_id","subj":"581","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T57","span":{"begin":214,"end":219},"obj":"Body_part"},{"id":"T58","span":{"begin":356,"end":359},"obj":"Body_part"},{"id":"T59","span":{"begin":422,"end":425},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":304,"end":309},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T121","span":{"begin":78,"end":86},"obj":"Disease"}],"attributes":[{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T131","span":{"begin":89,"end":94},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T132","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T133","span":{"begin":206,"end":219},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T134","span":{"begin":480,"end":481},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T135","span":{"begin":620,"end":621},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T238","span":{"begin":31,"end":41},"obj":"Chemical"},{"id":"T239","span":{"begin":46,"end":53},"obj":"Chemical"},{"id":"T240","span":{"begin":157,"end":167},"obj":"Chemical"},{"id":"T241","span":{"begin":182,"end":189},"obj":"Chemical"},{"id":"T242","span":{"begin":375,"end":379},"obj":"Chemical"},{"id":"T243","span":{"begin":453,"end":463},"obj":"Chemical"},{"id":"T244","span":{"begin":531,"end":541},"obj":"Chemical"},{"id":"T245","span":{"begin":546,"end":553},"obj":"Chemical"},{"id":"T246","span":{"begin":770,"end":775},"obj":"Chemical"}],"attributes":[{"id":"A238","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A239","pred":"chebi_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/CHEBI_4781"},{"id":"A240","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A241","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_4781"},{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A243","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A244","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A245","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_4781"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-sentences","denotations":[{"id":"T113","span":{"begin":0,"end":220},"obj":"Sentence"},{"id":"T114","span":{"begin":221,"end":685},"obj":"Sentence"},{"id":"T115","span":{"begin":686,"end":776},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T429","span":{"begin":31,"end":41},"obj":"DG_28"},{"id":"T430","span":{"begin":46,"end":53},"obj":"CHEBI:4781;CHEBI:4781"},{"id":"T431","span":{"begin":54,"end":69},"obj":"CHEBI:50488;CHEBI:50488"},{"id":"T432","span":{"begin":78,"end":88},"obj":"SP_7"},{"id":"T433","span":{"begin":89,"end":94},"obj":"NCBITaxon:10239"},{"id":"T434","span":{"begin":157,"end":167},"obj":"DG_28"},{"id":"T435","span":{"begin":182,"end":189},"obj":"CHEBI:4781;CHEBI:4781"},{"id":"T436","span":{"begin":206,"end":210},"obj":"CL_6"},{"id":"T437","span":{"begin":239,"end":244},"obj":"NCBITaxon:10239"},{"id":"T438","span":{"begin":280,"end":285},"obj":"NCBITaxon:10239"},{"id":"T439","span":{"begin":350,"end":355},"obj":"NCBITaxon:10239"},{"id":"T440","span":{"begin":375,"end":379},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T441","span":{"begin":453,"end":463},"obj":"DG_28"},{"id":"T442","span":{"begin":531,"end":541},"obj":"DG_28"},{"id":"T443","span":{"begin":770,"end":775},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T444","span":{"begin":31,"end":41},"obj":"DG_28"},{"id":"T445","span":{"begin":46,"end":53},"obj":"CHEBI:4781;CHEBI:4781"},{"id":"T446","span":{"begin":54,"end":69},"obj":"CHEBI:50488;CHEBI:50488"},{"id":"T447","span":{"begin":78,"end":88},"obj":"SP_7"},{"id":"T448","span":{"begin":89,"end":94},"obj":"NCBITaxon:10239"},{"id":"T449","span":{"begin":157,"end":167},"obj":"DG_28"},{"id":"T450","span":{"begin":182,"end":189},"obj":"CHEBI:4781;CHEBI:4781"},{"id":"T451","span":{"begin":206,"end":210},"obj":"CL_6"},{"id":"T452","span":{"begin":239,"end":244},"obj":"NCBITaxon:10239"},{"id":"T453","span":{"begin":280,"end":285},"obj":"NCBITaxon:10239"},{"id":"T454","span":{"begin":350,"end":355},"obj":"NCBITaxon:10239"},{"id":"T455","span":{"begin":375,"end":379},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T456","span":{"begin":453,"end":463},"obj":"DG_28"},{"id":"T457","span":{"begin":531,"end":541},"obj":"DG_28"},{"id":"T458","span":{"begin":770,"end":775},"obj":"CHEBI:23888;CHEBI:23888"}],"text":"Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. Red colour indicates synergy while the green colour indicates antagonism of the two drugs."}