PMC:7127386 / 17445-18221
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 573 | 78-88 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 574 | 31-41 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 575 | 46-69 | Chemical | denotes | emetine dihydrochloride | MESH:D004640 |
| 576 | 157-167 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 577 | 182-189 | Chemical | denotes | emetine | MESH:D004640 |
| 578 | 453-463 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 579 | 531-541 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 580 | 546-553 | Chemical | denotes | emetine | MESH:D004640 |
| 581 | 211-213 | CellLine | denotes | E6 | CVCL:4582 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T57 | 214-219 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T58 | 356-359 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T59 | 422-425 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 304-309 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T121 | 78-86 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T131 | 89-94 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T132 | 106-107 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T133 | 206-219 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
| T134 | 480-481 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T135 | 620-621 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T238 | 31-41 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T239 | 46-53 | Chemical | denotes | emetine | http://purl.obolibrary.org/obo/CHEBI_4781 |
| T240 | 157-167 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T241 | 182-189 | Chemical | denotes | emetine | http://purl.obolibrary.org/obo/CHEBI_4781 |
| T242 | 375-379 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T243 | 453-463 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T244 | 531-541 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T245 | 546-553 | Chemical | denotes | emetine | http://purl.obolibrary.org/obo/CHEBI_4781 |
| T246 | 770-775 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T113 | 0-220 | Sentence | denotes | Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells. |
| T114 | 221-685 | Sentence | denotes | The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model. |
| T115 | 686-776 | Sentence | denotes | Red colour indicates synergy while the green colour indicates antagonism of the two drugs. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T429 | 31-41 | DG_28 | denotes | remdesivir |
| T430 | 46-53 | CHEBI:4781;CHEBI:4781 | denotes | emetine |
| T431 | 54-69 | CHEBI:50488;CHEBI:50488 | denotes | dihydrochloride |
| T432 | 78-88 | SP_7 | denotes | SARS-CoV-2 |
| T433 | 89-94 | NCBITaxon:10239 | denotes | virus |
| T434 | 157-167 | DG_28 | denotes | remdesivir |
| T435 | 182-189 | CHEBI:4781;CHEBI:4781 | denotes | emetine |
| T436 | 206-210 | CL_6 | denotes | Vero |
| T437 | 239-244 | NCBITaxon:10239 | denotes | viral |
| T438 | 280-285 | NCBITaxon:10239 | denotes | viral |
| T439 | 350-355 | NCBITaxon:10239 | denotes | viral |
| T440 | 375-379 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T441 | 453-463 | DG_28 | denotes | remdesivir |
| T442 | 531-541 | DG_28 | denotes | remdesivir |
| T443 | 770-775 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T444 | 31-41 | DG_28 | denotes | remdesivir |
| T445 | 46-53 | CHEBI:4781;CHEBI:4781 | denotes | emetine |
| T446 | 54-69 | CHEBI:50488;CHEBI:50488 | denotes | dihydrochloride |
| T447 | 78-88 | SP_7 | denotes | SARS-CoV-2 |
| T448 | 89-94 | NCBITaxon:10239 | denotes | virus |
| T449 | 157-167 | DG_28 | denotes | remdesivir |
| T450 | 182-189 | CHEBI:4781;CHEBI:4781 | denotes | emetine |
| T451 | 206-210 | CL_6 | denotes | Vero |
| T452 | 239-244 | NCBITaxon:10239 | denotes | viral |
| T453 | 280-285 | NCBITaxon:10239 | denotes | viral |
| T454 | 350-355 | NCBITaxon:10239 | denotes | viral |
| T455 | 375-379 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T456 | 453-463 | DG_28 | denotes | remdesivir |
| T457 | 531-541 | DG_28 | denotes | remdesivir |
| T458 | 770-775 | CHEBI:23888;CHEBI:23888 | denotes | drugs |