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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":258,"end":267},"obj":"Body_part"},{"id":"T79","span":{"begin":281,"end":291},"obj":"Body_part"},{"id":"T80","span":{"begin":1930,"end":1940},"obj":"Body_part"},{"id":"T81","span":{"begin":2006,"end":2016},"obj":"Body_part"},{"id":"T82","span":{"begin":2230,"end":2235},"obj":"Body_part"},{"id":"T83","span":{"begin":2250,"end":2253},"obj":"Body_part"},{"id":"T84","span":{"begin":2341,"end":2346},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma9670"}],"text":"7 Diagnosis\nThe earliest cases of SARS-CoV-2 were identified as “pneumonia of unknown etiology”, which was defined as an illness of unknown etiology with 1. Fever with or without a recorded temperature 2. Radiographic evidence of pneumonia 3. Low or normal leukocyte count or low lymphocyte count during the early stage of disease and 4. No improvement or worsening symptoms after 3–5 days of antimicrobial treatment per standard clinical guidelines [61]. With increasing research and knowledge of the disease, diagnosis and treatment guidelines have been continuously updated. At present, the NHC has issued the fifth edition of the guidelines. However, because of a shortage of diagnostic reagents for SARS-CoV-2 detection, different guidelines or programs emphasized comprehensive analysis based on epidemiological history, clinical manifestations and imaging examinations in diagnosis.\n\n7.1 Diagnostic criteria [37,[78], [79], [80], [81], [82]]\nThe diagnostic criteria of suspected and confirmed cases were summarized in Table 1 .\nTable 1 The diagnostic criteria for suspected and confirmed cases [37,[77], [78], [79], [80], [81]].\nCase Diagnostic criteria\nSuspected case Anyone with a history of epidemiology and any two of the clinical manifestations or anyone without epidemiological history and three of the clinical manifestations is considered to be a suspected case:\n(1) Epidemiological history:1) within 14 days before the disease onset, there is a travel history or living history in Wuhan or other areas with local cases\n2) within 14 days before the disease onset, there is contact with patients who had fever or respiratory symptoms from Wuhan or other areas with local cases\n3) a clustering of patients or a contact with patients infected with the SARS-CoV-2\n(2) Clinical manifestations:1) fever and/or respiratory symptoms\n2) with the above-mentioned imaging characteristics of pneumonia\n3) the total number of leukocytes in the early stage of the disease is normal or decreased, or the lymphocyte count is decreased\nConfirmed case Any suspected case with one of the following pathogenic features is reclassified as a confirmed case:\n(1) Positive results of SARS-CoV-2 nucleic acids by RT-PCR of respiratory or blood specimens\n(2) DNA highly homologous to SARS-CoV-2 by genetic sequencing of viral genes in respiratory or blood specimens\nRT-PCR: real-time reverse-transcriptase polymerase-chain-reaction.\n\n7.2 Differential diagnosis\nThe SARS-CoV-2 needs to be distinguished from other known viral pneumonias including influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, SARS coronavirus, MERS coronavirus, as well as Mycoplasma pneumoniae, chlamydia pneumonia, and bacterial pneumonias. For patients with underlying diseases, attention should be paid to the detection of invasive fungal infections. The differential diagnosis also includes non-infectious diseases such as vasculitis, dermatomyositis, and organizing pneumonia. It should be noted that often patients with viral pneumonia may test positive to multiple viruses, and the potential lethality of a combined SARS-CoV-2/influenza virus infection should not be ignored."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T42","span":{"begin":2230,"end":2235},"obj":"Body_part"},{"id":"T43","span":{"begin":2341,"end":2346},"obj":"Body_part"}],"attributes":[{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"7 Diagnosis\nThe earliest cases of SARS-CoV-2 were identified as “pneumonia of unknown etiology”, which was defined as an illness of unknown etiology with 1. Fever with or without a recorded temperature 2. Radiographic evidence of pneumonia 3. Low or normal leukocyte count or low lymphocyte count during the early stage of disease and 4. No improvement or worsening symptoms after 3–5 days of antimicrobial treatment per standard clinical guidelines [61]. With increasing research and knowledge of the disease, diagnosis and treatment guidelines have been continuously updated. At present, the NHC has issued the fifth edition of the guidelines. However, because of a shortage of diagnostic reagents for SARS-CoV-2 detection, different guidelines or programs emphasized comprehensive analysis based on epidemiological history, clinical manifestations and imaging examinations in diagnosis.\n\n7.1 Diagnostic criteria [37,[78], [79], [80], [81], [82]]\nThe diagnostic criteria of suspected and confirmed cases were summarized in Table 1 .\nTable 1 The diagnostic criteria for suspected and confirmed cases [37,[77], [78], [79], [80], [81]].\nCase Diagnostic criteria\nSuspected case Anyone with a history of epidemiology and any two of the clinical manifestations or anyone without epidemiological history and three of the clinical manifestations is considered to be a suspected case:\n(1) Epidemiological history:1) within 14 days before the disease onset, there is a travel history or living history in Wuhan or other areas with local cases\n2) within 14 days before the disease onset, there is contact with patients who had fever or respiratory symptoms from Wuhan or other areas with local cases\n3) a clustering of patients or a contact with patients infected with the SARS-CoV-2\n(2) Clinical manifestations:1) fever and/or respiratory symptoms\n2) with the above-mentioned imaging characteristics of pneumonia\n3) the total number of leukocytes in the early stage of the disease is normal or decreased, or the lymphocyte count is decreased\nConfirmed case Any suspected case with one of the following pathogenic features is reclassified as a confirmed case:\n(1) Positive results of SARS-CoV-2 nucleic acids by RT-PCR of respiratory or blood specimens\n(2) DNA highly homologous to SARS-CoV-2 by genetic sequencing of viral genes in respiratory or blood specimens\nRT-PCR: real-time reverse-transcriptase polymerase-chain-reaction.\n\n7.2 Differential diagnosis\nThe SARS-CoV-2 needs to be distinguished from other known viral pneumonias including influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, SARS coronavirus, MERS coronavirus, as well as Mycoplasma pneumoniae, chlamydia pneumonia, and bacterial pneumonias. For patients with underlying diseases, attention should be paid to the detection of invasive fungal infections. The differential diagnosis also includes non-infectious diseases such as vasculitis, dermatomyositis, and organizing pneumonia. It should be noted that often patients with viral pneumonia may test positive to multiple viruses, and the potential lethality of a combined SARS-CoV-2/influenza virus infection should not be ignored."}

LitCovid_AGAC

{"project":"LitCovid_AGAC","denotations":[{"id":"p84012s24","span":{"begin":2026,"end":2035},"obj":"NegReg"}],"text":"7 Diagnosis\nThe earliest cases of SARS-CoV-2 were identified as “pneumonia of unknown etiology”, which was defined as an illness of unknown etiology with 1. Fever with or without a recorded temperature 2. Radiographic evidence of pneumonia 3. Low or normal leukocyte count or low lymphocyte count during the early stage of disease and 4. No improvement or worsening symptoms after 3–5 days of antimicrobial treatment per standard clinical guidelines [61]. With increasing research and knowledge of the disease, diagnosis and treatment guidelines have been continuously updated. At present, the NHC has issued the fifth edition of the guidelines. However, because of a shortage of diagnostic reagents for SARS-CoV-2 detection, different guidelines or programs emphasized comprehensive analysis based on epidemiological history, clinical manifestations and imaging examinations in diagnosis.\n\n7.1 Diagnostic criteria [37,[78], [79], [80], [81], [82]]\nThe diagnostic criteria of suspected and confirmed cases were summarized in Table 1 .\nTable 1 The diagnostic criteria for suspected and confirmed cases [37,[77], [78], [79], [80], [81]].\nCase Diagnostic criteria\nSuspected case Anyone with a history of epidemiology and any two of the clinical manifestations or anyone without epidemiological history and three of the clinical manifestations is considered to be a suspected case:\n(1) Epidemiological history:1) within 14 days before the disease onset, there is a travel history or living history in Wuhan or other areas with local cases\n2) within 14 days before the disease onset, there is contact with patients who had fever or respiratory symptoms from Wuhan or other areas with local cases\n3) a clustering of patients or a contact with patients infected with the SARS-CoV-2\n(2) Clinical manifestations:1) fever and/or respiratory symptoms\n2) with the above-mentioned imaging characteristics of pneumonia\n3) the total number of leukocytes in the early stage of the disease is normal or decreased, or the lymphocyte count is decreased\nConfirmed case Any suspected case with one of the following pathogenic features is reclassified as a confirmed case:\n(1) Positive results of SARS-CoV-2 nucleic acids by RT-PCR of respiratory or blood specimens\n(2) DNA highly homologous to SARS-CoV-2 by genetic sequencing of viral genes in respiratory or blood specimens\nRT-PCR: real-time reverse-transcriptase polymerase-chain-reaction.\n\n7.2 Differential diagnosis\nThe SARS-CoV-2 needs to be distinguished from other known viral pneumonias including influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, SARS coronavirus, MERS coronavirus, as well as Mycoplasma pneumoniae, chlamydia pneumonia, and bacterial pneumonias. For patients with underlying diseases, attention should be paid to the detection of invasive fungal infections. The differential diagnosis also includes non-infectious diseases such as vasculitis, dermatomyositis, and organizing pneumonia. It should be noted that often patients with viral pneumonia may test positive to multiple viruses, and the potential lethality of a combined SARS-CoV-2/influenza virus infection should not be ignored."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T62","span":{"begin":394,"end":407},"obj":"Chemical"},{"id":"T63","span":{"begin":595,"end":598},"obj":"Chemical"},{"id":"T64","span":{"begin":692,"end":700},"obj":"Chemical"},{"id":"T65","span":{"begin":2188,"end":2201},"obj":"Chemical"},{"id":"T66","span":{"begin":2196,"end":2201},"obj":"Chemical"},{"id":"T67","span":{"begin":2250,"end":2253},"obj":"Chemical"}],"attributes":[{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_51369"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_33893"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"7 Diagnosis\nThe earliest cases of SARS-CoV-2 were identified as “pneumonia of unknown etiology”, which was defined as an illness of unknown etiology with 1. Fever with or without a recorded temperature 2. Radiographic evidence of pneumonia 3. Low or normal leukocyte count or low lymphocyte count during the early stage of disease and 4. No improvement or worsening symptoms after 3–5 days of antimicrobial treatment per standard clinical guidelines [61]. With increasing research and knowledge of the disease, diagnosis and treatment guidelines have been continuously updated. At present, the NHC has issued the fifth edition of the guidelines. However, because of a shortage of diagnostic reagents for SARS-CoV-2 detection, different guidelines or programs emphasized comprehensive analysis based on epidemiological history, clinical manifestations and imaging examinations in diagnosis.\n\n7.1 Diagnostic criteria [37,[78], [79], [80], [81], [82]]\nThe diagnostic criteria of suspected and confirmed cases were summarized in Table 1 .\nTable 1 The diagnostic criteria for suspected and confirmed cases [37,[77], [78], [79], [80], [81]].\nCase Diagnostic criteria\nSuspected case Anyone with a history of epidemiology and any two of the clinical manifestations or anyone without epidemiological history and three of the clinical manifestations is considered to be a suspected case:\n(1) Epidemiological history:1) within 14 days before the disease onset, there is a travel history or living history in Wuhan or other areas with local cases\n2) within 14 days before the disease onset, there is contact with patients who had fever or respiratory symptoms from Wuhan or other areas with local cases\n3) a clustering of patients or a contact with patients infected with the SARS-CoV-2\n(2) Clinical manifestations:1) fever and/or respiratory symptoms\n2) with the above-mentioned imaging characteristics of pneumonia\n3) the total number of leukocytes in the early stage of the disease is normal or decreased, or the lymphocyte count is decreased\nConfirmed case Any suspected case with one of the following pathogenic features is reclassified as a confirmed case:\n(1) Positive results of SARS-CoV-2 nucleic acids by RT-PCR of respiratory or blood specimens\n(2) DNA highly homologous to SARS-CoV-2 by genetic sequencing of viral genes in respiratory or blood specimens\nRT-PCR: real-time reverse-transcriptase polymerase-chain-reaction.\n\n7.2 Differential diagnosis\nThe SARS-CoV-2 needs to be distinguished from other known viral pneumonias including influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, SARS coronavirus, MERS coronavirus, as well as Mycoplasma pneumoniae, chlamydia pneumonia, and bacterial pneumonias. For patients with underlying diseases, attention should be paid to the detection of invasive fungal infections. The differential diagnosis also includes non-infectious diseases such as vasculitis, dermatomyositis, and organizing pneumonia. It should be noted that often patients with viral pneumonia may test positive to multiple viruses, and the potential lethality of a combined SARS-CoV-2/influenza virus infection should not be ignored."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":2383,"end":2396},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T24","span":{"begin":2383,"end":2396},"obj":"http://purl.obolibrary.org/obo/GO_0003899"}],"text":"7 Diagnosis\nThe earliest cases of SARS-CoV-2 were identified as “pneumonia of unknown etiology”, which was defined as an illness of unknown etiology with 1. Fever with or without a recorded temperature 2. Radiographic evidence of pneumonia 3. Low or normal leukocyte count or low lymphocyte count during the early stage of disease and 4. No improvement or worsening symptoms after 3–5 days of antimicrobial treatment per standard clinical guidelines [61]. With increasing research and knowledge of the disease, diagnosis and treatment guidelines have been continuously updated. At present, the NHC has issued the fifth edition of the guidelines. However, because of a shortage of diagnostic reagents for SARS-CoV-2 detection, different guidelines or programs emphasized comprehensive analysis based on epidemiological history, clinical manifestations and imaging examinations in diagnosis.\n\n7.1 Diagnostic criteria [37,[78], [79], [80], [81], [82]]\nThe diagnostic criteria of suspected and confirmed cases were summarized in Table 1 .\nTable 1 The diagnostic criteria for suspected and confirmed cases [37,[77], [78], [79], [80], [81]].\nCase Diagnostic criteria\nSuspected case Anyone with a history of epidemiology and any two of the clinical manifestations or anyone without epidemiological history and three of the clinical manifestations is considered to be a suspected case:\n(1) Epidemiological history:1) within 14 days before the disease onset, there is a travel history or living history in Wuhan or other areas with local cases\n2) within 14 days before the disease onset, there is contact with patients who had fever or respiratory symptoms from Wuhan or other areas with local cases\n3) a clustering of patients or a contact with patients infected with the SARS-CoV-2\n(2) Clinical manifestations:1) fever and/or respiratory symptoms\n2) with the above-mentioned imaging characteristics of pneumonia\n3) the total number of leukocytes in the early stage of the disease is normal or decreased, or the lymphocyte count is decreased\nConfirmed case Any suspected case with one of the following pathogenic features is reclassified as a confirmed case:\n(1) Positive results of SARS-CoV-2 nucleic acids by RT-PCR of respiratory or blood specimens\n(2) DNA highly homologous to SARS-CoV-2 by genetic sequencing of viral genes in respiratory or blood specimens\nRT-PCR: real-time reverse-transcriptase polymerase-chain-reaction.\n\n7.2 Differential diagnosis\nThe SARS-CoV-2 needs to be distinguished from other known viral pneumonias including influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, SARS coronavirus, MERS coronavirus, as well as Mycoplasma pneumoniae, chlamydia pneumonia, and bacterial pneumonias. For patients with underlying diseases, attention should be paid to the detection of invasive fungal infections. The differential diagnosis also includes non-infectious diseases such as vasculitis, dermatomyositis, and organizing pneumonia. It should be noted that often patients with viral pneumonia may test positive to multiple viruses, and the potential lethality of a combined SARS-CoV-2/influenza virus infection should not be ignored."}

LitCovid-PD-HP

LitCovid-sentences

LitCovid-PubTator

PMC:7126544 / 36498-39707 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7126544 / 36498-39707 JSON TXT