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PMC:7121452 / 75-1166 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
21 404-435 Gene denotes angiotensin-converting enzyme 2 Gene:59272
22 437-441 Gene denotes ACE2 Gene:59272
23 604-608 Gene denotes ACE2 Gene:59272
24 745-749 Gene denotes ACE2 Gene:59272
25 775-779 Gene denotes ACE2 Gene:59272
26 971-974 Gene denotes ACE Gene:1636
27 127-132 Species denotes human Tax:9606
28 145-190 Species denotes Severe acute respiratory syndrome coronavirus Tax:694009
29 194-202 Species denotes SARS-CoV Tax:694009
30 210-220 Species denotes SARS-CoV-2 Tax:2697049
31 22-33 Chemical denotes aldosterone MESH:D000450
32 312-336 Disease denotes coronavirus disease 2019 MESH:C000657245
33 338-346 Disease denotes Covid-19 MESH:C000657245
34 855-863 Disease denotes Covid-19 MESH:C000657245
35 1082-1090 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 145-178 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T2 194-202 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 210-218 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 258-262 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 312-336 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T6 542-546 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 587-591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 84-92 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T2 127-132 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 489-499 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T4 522-523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 547-554 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T6 592-599 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T7 609-612 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T8 630-631 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T3 10-21 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 22-33 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T6 84-92 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T7 404-415 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T8 719-729 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T9 971-985 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T10 975-985 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T11 990-1001 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 830-839 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T2 830-839 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-144 Sentence denotes The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human physiology.
T3 145-1091 Sentence denotes Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2, which have been responsible for the SARS epidemic in 2002 to 2004 and for the more recent coronavirus disease 2019 (Covid-19) pandemic, respectively, interface with the RAAS through angiotensin-converting enzyme 2 (ACE2), an enzyme that physiologically counters RAAS activation but also functions as a receptor for both SARS viruses.1,2 The interaction between the SARS viruses and ACE2 has been proposed as a potential factor in their infectivity,3,4 and there are concerns about the use of RAAS inhibitors that may alter ACE2 and whether variation in ACE2 expression may be in part responsible for disease virulence in the ongoing Covid-19 pandemic.5-8 Indeed, some media sources and health systems have recently called for the discontinuation of ACE inhibitors and angiotensin-receptor blockers (ARBs), both prophylactically and in the context of suspected Covid-19.