PMC:7121452 / 17707-18325 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"966","span":{"begin":20,"end":30},"obj":"Species"},{"id":"967","span":{"begin":57,"end":68},"obj":"Chemical"},{"id":"978","span":{"begin":253,"end":284},"obj":"Gene"},{"id":"979","span":{"begin":286,"end":290},"obj":"Gene"},{"id":"980","span":{"begin":341,"end":345},"obj":"Gene"},{"id":"981","span":{"begin":396,"end":410},"obj":"Gene"},{"id":"982","span":{"begin":538,"end":541},"obj":"Gene"},{"id":"983","span":{"begin":550,"end":579},"obj":"Gene"},{"id":"984","span":{"begin":107,"end":154},"obj":"Species"},{"id":"985","span":{"begin":156,"end":166},"obj":"Species"},{"id":"986","span":{"begin":467,"end":478},"obj":"Chemical"},{"id":"987","span":{"begin":498,"end":509},"obj":"Disease"}],"attributes":[{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Tax:2697049"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"MESH:D000450"},{"id":"A978","pred":"tao:has_database_id","subj":"978","obj":"Gene:59272"},{"id":"A979","pred":"tao:has_database_id","subj":"979","obj":"Gene:59272"},{"id":"A980","pred":"tao:has_database_id","subj":"980","obj":"Gene:59272"},{"id":"A981","pred":"tao:has_database_id","subj":"981","obj":"Gene:183"},{"id":"A982","pred":"tao:has_database_id","subj":"982","obj":"Gene:1636"},{"id":"A983","pred":"tao:has_database_id","subj":"983","obj":"Gene:1636"},{"id":"A984","pred":"tao:has_database_id","subj":"984","obj":"Tax:2697049"},{"id":"A985","pred":"tao:has_database_id","subj":"985","obj":"Tax:2697049"},{"id":"A986","pred":"tao:has_database_id","subj":"986","obj":"MESH:D000450"},{"id":"A987","pred":"tao:has_database_id","subj":"987","obj":"MESH:D055370"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T63","span":{"begin":173,"end":178},"obj":"Body_part"},{"id":"T64","span":{"begin":198,"end":209},"obj":"Body_part"},{"id":"T65","span":{"begin":498,"end":502},"obj":"Body_part"}],"attributes":[{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T39","span":{"begin":498,"end":502},"obj":"Body_part"}],"attributes":[{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p78855s7","span":{"begin":333,"end":345},"obj":"MPA"},{"id":"p78855s17","span":{"begin":386,"end":410},"obj":"MPA"},{"id":"p78855s20","span":{"begin":411,"end":423},"obj":"PosReg"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T83","span":{"begin":20,"end":28},"obj":"Disease"},{"id":"T84","span":{"begin":107,"end":154},"obj":"Disease"},{"id":"T85","span":{"begin":107,"end":140},"obj":"Disease"},{"id":"T86","span":{"begin":156,"end":164},"obj":"Disease"},{"id":"T87","span":{"begin":503,"end":509},"obj":"Disease"},{"id":"T88","span":{"begin":585,"end":588},"obj":"Disease"}],"attributes":[{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0012733"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T192","span":{"begin":173,"end":178},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T193","span":{"begin":431,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T194","span":{"begin":498,"end":502},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T195","span":{"begin":498,"end":502},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T154","span":{"begin":45,"end":56},"obj":"Chemical"},{"id":"T155","span":{"begin":57,"end":68},"obj":"Chemical"},{"id":"T156","span":{"begin":195,"end":197},"obj":"Chemical"},{"id":"T157","span":{"begin":253,"end":264},"obj":"Chemical"},{"id":"T158","span":{"begin":396,"end":410},"obj":"Chemical"},{"id":"T161","span":{"begin":396,"end":407},"obj":"Chemical"},{"id":"T162","span":{"begin":408,"end":410},"obj":"Chemical"},{"id":"T163","span":{"begin":455,"end":466},"obj":"Chemical"},{"id":"T164","span":{"begin":467,"end":478},"obj":"Chemical"},{"id":"T166","span":{"begin":550,"end":561},"obj":"Chemical"},{"id":"T167","span":{"begin":589,"end":600},"obj":"Chemical"}],"attributes":[{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A159","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A160","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A165","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":299,"end":310},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}

{"project":"LitCovid-sentences","denotations":[{"id":"T69","span":{"begin":77,"end":292},"obj":"Sentence"},{"id":"T70","span":{"begin":293,"end":424},"obj":"Sentence"},{"id":"T71","span":{"begin":425,"end":537},"obj":"Sentence"},{"id":"T72","span":{"begin":538,"end":618},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker."}