PMC:7121452 / 17697-18325 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7121452","sourcedb":"PMC","sourceid":"7121452","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7121452","text":"Figure 1 Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.\nShown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. 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