PMC:7121452 / 17697-18325
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 966 | 30-40 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 967 | 67-78 | Chemical | denotes | Aldosterone | MESH:D000450 |
| 978 | 263-294 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 979 | 296-300 | Gene | denotes | ACE2 | Gene:59272 |
| 980 | 351-355 | Gene | denotes | ACE2 | Gene:59272 |
| 981 | 406-420 | Gene | denotes | angiotensin II | Gene:183 |
| 982 | 548-551 | Gene | denotes | ACE | Gene:1636 |
| 983 | 560-589 | Gene | denotes | angiotensin-converting enzyme | Gene:1636 |
| 984 | 117-164 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 985 | 166-176 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 986 | 477-488 | Chemical | denotes | aldosterone | MESH:D000450 |
| 987 | 508-519 | Disease | denotes | lung injury | MESH:D055370 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T63 | 183-188 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T64 | 208-219 | Body_part | denotes | pneumocytes | http://purl.org/sig/ont/fma/fma62499 |
| T65 | 508-512 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T39 | 508-512 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p78855s7 | 343-355 | MPA | denotes | surface ACE2 |
| p78855s17 | 396-420 | MPA | denotes | unopposed angiotensin II |
| p78855s20 | 421-433 | PosReg | denotes | accumulation |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T83 | 30-38 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T84 | 117-164 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T85 | 117-150 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T86 | 166-174 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T87 | 513-519 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T88 | 595-598 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T192 | 183-188 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T193 | 441-451 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T194 | 508-512 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T195 | 508-512 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T154 | 55-66 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T155 | 67-78 | Chemical | denotes | Aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584 |
| T156 | 205-207 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T157 | 263-274 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T158 | 406-420 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
| T161 | 406-417 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T162 | 418-420 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T163 | 465-476 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T164 | 477-488 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T166 | 560-571 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T167 | 599-610 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 309-320 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T68 | 0-86 | Sentence | denotes | Figure 1 Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System. |
| T69 | 87-302 | Sentence | denotes | Shown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). |
| T70 | 303-434 | Sentence | denotes | After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. |
| T71 | 435-547 | Sentence | denotes | Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. |
| T72 | 548-628 | Sentence | denotes | ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker. |