PMC:7116472 / 1095-2269 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"38","span":{"begin":375,"end":393},"obj":"Gene"},{"id":"39","span":{"begin":15,"end":23},"obj":"Species"},{"id":"40","span":{"begin":713,"end":721},"obj":"Species"},{"id":"41","span":{"begin":316,"end":322},"obj":"Chemical"},{"id":"42","span":{"begin":359,"end":363},"obj":"Chemical"},{"id":"43","span":{"begin":65,"end":74},"obj":"Disease"},{"id":"44","span":{"begin":125,"end":134},"obj":"Disease"},{"id":"45","span":{"begin":161,"end":170},"obj":"Disease"},{"id":"46","span":{"begin":465,"end":474},"obj":"Disease"},{"id":"47","span":{"begin":774,"end":783},"obj":"Disease"},{"id":"48","span":{"begin":833,"end":842},"obj":"Disease"},{"id":"49","span":{"begin":1115,"end":1123},"obj":"Disease"}],"attributes":[{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Gene:1401"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"Tax:9606"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"Tax:9606"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D010100"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D014508"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D003643"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D003643"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D003643"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:D003643"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D003643"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"MESH:D003643"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Results\n35 463 patients were included in the derivation dataset (mortality rate 32.2%) and 22 361 in the validation dataset (mortality rate 30.1%). The final 4C Mortality Score included eight variables readily available at initial hospital assessment: age, sex, number of comorbidities, respiratory rate, peripheral oxygen saturation, level of consciousness, urea level, and C reactive protein (score range 0-21 points). The 4C Score showed high discrimination for mortality (derivation cohort: area under the receiver operating characteristic curve 0.79, 95% confidence interval 0.78 to 0.79; validation cohort: 0.77, 0.76 to 0.77) with excellent calibration (validation: calibration-in-the-large=0, slope=1.0). Patients with a score of at least 15 (n=4158, 19%) had a 62% mortality (positive predictive value 62%) compared with 1% mortality for those with a score of 3 or less (n=1650, 7%; negative predictive value 99%). Discriminatory performance was higher than 15 pre-existing risk stratification scores (area under the receiver operating characteristic curve range 0.61-0.76), with scores developed in other covid-19 cohorts often performing poorly (range 0.63-0.73)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T14","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T15","span":{"begin":8,"end":147},"obj":"Sentence"},{"id":"T16","span":{"begin":148,"end":420},"obj":"Sentence"},{"id":"T17","span":{"begin":421,"end":612},"obj":"Sentence"},{"id":"T18","span":{"begin":613,"end":712},"obj":"Sentence"},{"id":"T19","span":{"begin":713,"end":923},"obj":"Sentence"},{"id":"T20","span":{"begin":924,"end":1174},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results\n35 463 patients were included in the derivation dataset (mortality rate 32.2%) and 22 361 in the validation dataset (mortality rate 30.1%). The final 4C Mortality Score included eight variables readily available at initial hospital assessment: age, sex, number of comorbidities, respiratory rate, peripheral oxygen saturation, level of consciousness, urea level, and C reactive protein (score range 0-21 points). The 4C Score showed high discrimination for mortality (derivation cohort: area under the receiver operating characteristic curve 0.79, 95% confidence interval 0.78 to 0.79; validation cohort: 0.77, 0.76 to 0.77) with excellent calibration (validation: calibration-in-the-large=0, slope=1.0). Patients with a score of at least 15 (n=4158, 19%) had a 62% mortality (positive predictive value 62%) compared with 1% mortality for those with a score of 3 or less (n=1650, 7%; negative predictive value 99%). Discriminatory performance was higher than 15 pre-existing risk stratification scores (area under the receiver operating characteristic curve range 0.61-0.76), with scores developed in other covid-19 cohorts often performing poorly (range 0.63-0.73)."}