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PMC:7116472 / 1095-2269 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
38 375-393 Gene denotes C reactive protein Gene:1401
39 15-23 Species denotes patients Tax:9606
40 713-721 Species denotes Patients Tax:9606
41 316-322 Chemical denotes oxygen MESH:D010100
42 359-363 Chemical denotes urea MESH:D014508
43 65-74 Disease denotes mortality MESH:D003643
44 125-134 Disease denotes mortality MESH:D003643
45 161-170 Disease denotes Mortality MESH:D003643
46 465-474 Disease denotes mortality MESH:D003643
47 774-783 Disease denotes mortality MESH:D003643
48 833-842 Disease denotes mortality MESH:D003643
49 1115-1123 Disease denotes covid-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T14 0-7 Sentence denotes Results
T15 8-147 Sentence denotes 35 463 patients were included in the derivation dataset (mortality rate 32.2%) and 22 361 in the validation dataset (mortality rate 30.1%).
T16 148-420 Sentence denotes The final 4C Mortality Score included eight variables readily available at initial hospital assessment: age, sex, number of comorbidities, respiratory rate, peripheral oxygen saturation, level of consciousness, urea level, and C reactive protein (score range 0-21 points).
T17 421-612 Sentence denotes The 4C Score showed high discrimination for mortality (derivation cohort: area under the receiver operating characteristic curve 0.79, 95% confidence interval 0.78 to 0.79; validation cohort:
T18 613-712 Sentence denotes 0.77, 0.76 to 0.77) with excellent calibration (validation: calibration-in-the-large=0, slope=1.0).
T19 713-923 Sentence denotes Patients with a score of at least 15 (n=4158, 19%) had a 62% mortality (positive predictive value 62%) compared with 1% mortality for those with a score of 3 or less (n=1650, 7%; negative predictive value 99%).
T20 924-1174 Sentence denotes Discriminatory performance was higher than 15 pre-existing risk stratification scores (area under the receiver operating characteristic curve range 0.61-0.76), with scores developed in other covid-19 cohorts often performing poorly (range 0.63-0.73).