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PMC:7115396 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 34994-35005 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 66-73 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 77-81 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T3 316-324 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T4 365-369 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T5 952-960 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T6 1001-1005 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T7 1130-1137 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T8 1183-1190 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T9 1422-1427 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T10 1431-1438 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T11 1513-1520 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T12 1969-1974 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T13 2483-2501 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T14 2568-2572 Body_part denotes head http://purl.org/sig/ont/fma/fma7154
T15 2714-2720 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T16 2925-2928 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T17 3049-3052 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T18 3053-3059 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T19 3115-3123 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T20 3140-3148 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T21 3170-3178 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T22 3246-3253 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 3331-3338 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 3414-3419 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 3768-3778 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T26 3797-3801 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T27 4764-4771 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T28 5489-5495 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T29 5496-5501 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 5684-5690 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T31 5799-5802 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T32 5895-5899 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T33 7366-7374 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T34 7414-7418 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T35 8278-8285 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T36 8603-8610 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T37 8967-8973 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T38 8974-8977 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T39 9009-9012 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T40 9052-9057 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T41 9099-9103 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 9201-9208 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T43 9262-9268 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T44 9394-9398 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T45 9610-9614 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T46 9980-9984 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T47 10102-10108 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T48 10292-10302 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T49 10431-10435 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T50 10608-10614 Body_part denotes embryo http://purl.org/sig/ont/fma/fma296970
T51 10683-10690 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T52 10807-10815 Body_part denotes cavities http://purl.org/sig/ont/fma/fma76576
T53 10885-10891 Body_part denotes embryo http://purl.org/sig/ont/fma/fma296970
T54 10995-11002 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T55 11050-11057 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T56 11866-11869 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T57 12086-12089 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T58 12799-12806 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T59 13237-13244 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T60 13299-13306 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T61 13418-13425 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T62 13544-13550 Body_part denotes embryo http://purl.org/sig/ont/fma/fma296970
T63 14482-14486 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T64 14492-14498 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T65 14516-14522 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T66 14788-14791 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448
T67 14918-14926 Body_part denotes tracheas http://purl.org/sig/ont/fma/fma7394
T68 14928-14933 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T69 14935-14942 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T70 14948-14953 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T71 15138-15141 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T72 15317-15320 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T73 15733-15739 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T74 15811-15819 Body_part denotes tracheas http://purl.org/sig/ont/fma/fma7394
T75 15821-15826 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T76 15828-15835 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T77 16532-16535 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448
T78 16871-16874 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T79 17383-17386 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448
T80 17575-17579 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T81 17585-17591 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T82 17609-17617 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T83 18115-18120 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T84 18344-18347 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T85 18384-18387 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T86 18830-18838 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T87 18862-18868 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T88 19346-19353 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T89 19476-19482 Body_part denotes embryo http://purl.org/sig/ont/fma/fma296970
T90 19790-19797 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T91 19855-19862 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T92 20000-20006 Body_part denotes embryo http://purl.org/sig/ont/fma/fma296970
T93 21106-21109 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T94 21893-21907 Body_part denotes urinary system http://purl.org/sig/ont/fma/fma7159
T95 21919-21924 Body_part denotes mucus http://purl.org/sig/ont/fma/fma66938
T96 21959-21966 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T97 22016-22022 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T98 22066-22071 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T99 22358-22364 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T100 22844-22849 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T101 22854-22861 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T102 22910-22916 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T103 23001-23008 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T104 23065-23080 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T105 23076-23080 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T106 23164-23173 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T107 23198-23203 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T108 23240-23251 Body_part denotes erythrocyte http://purl.org/sig/ont/fma/fma62845
T109 23269-23273 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T110 23359-23370 Body_part denotes erythrocyte http://purl.org/sig/ont/fma/fma62845
T111 23375-23385 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T112 23448-23454 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T113 23597-23604 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T114 23668-23675 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T115 23701-23717 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T116 23712-23717 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 23759-23764 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T118 23788-23794 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T119 23863-23868 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T120 23873-23880 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T121 24035-24040 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T122 24107-24113 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T123 24208-24215 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T124 24217-24222 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T125 24224-24231 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T126 24237-24242 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T127 24364-24371 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T128 24426-24431 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T129 24468-24475 Body_part denotes Trachea http://purl.org/sig/ont/fma/fma7394
T130 24518-24522 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T131 24527-24532 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T132 24585-24591 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T133 24650-24657 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T134 24773-24777 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T135 24783-24789 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T136 24790-24797 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T137 24862-24869 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T138 24945-24951 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T139 25151-25158 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T140 25270-25273 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T141 25372-25376 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T142 25454-25457 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T143 25465-25470 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T144 25599-25605 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T145 25727-25733 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T146 25845-25848 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T147 26802-26805 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T148 27131-27134 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T149 28428-28434 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T150 28509-28516 Body_part denotes ureters http://purl.org/sig/ont/fma/fma9704
T151 29082-29089 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T152 29178-29186 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T153 29301-29309 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T154 29319-29329 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T155 29458-29466 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T156 29519-29527 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T157 29568-29576 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T158 29696-29701 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T159 29796-29801 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T160 29802-29810 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T161 30437-30440 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T162 31294-31297 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T163 31798-31802 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T164 31943-31947 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T165 32051-32059 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T166 32185-32189 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T167 32578-32584 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T168 32741-32745 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T169 32844-32854 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T170 32923-32933 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T171 33075-33081 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T172 33408-33412 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T173 33537-33544 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 33575-33583 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T175 33685-33689 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T176 33778-33785 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 33921-33926 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 33948-33952 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T179 34078-34082 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T180 34220-34227 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T181 34346-34362 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T182 34357-34362 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 34386-34393 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T184 34417-34423 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T185 34437-34442 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T186 34519-34526 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T187 34528-34532 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T188 34538-34544 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T189 34568-34574 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 34640-34644 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T191 34707-34711 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T192 34734-34741 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T193 34972-34977 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T194 35013-35025 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T195 35013-35017 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T196 35120-35124 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T197 35253-35259 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T198 35353-35360 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T199 35463-35470 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T200 35531-35536 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T201 35574-35579 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T202 35584-35591 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T203 35760-35766 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T204 35881-35887 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T205 35949-35957 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T206 35968-35972 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T207 36075-36082 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T208 36122-36129 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T209 36265-36272 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T210 36273-36289 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T211 36284-36289 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T212 36531-36537 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T213 36629-36637 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T214 36687-36695 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T215 36867-36874 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T216 36875-36885 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T217 37347-37355 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T218 37436-37444 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T219 37474-37477 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T220 37500-37505 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T221 37510-37517 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T222 37610-37614 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T223 37769-37776 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T224 37835-37842 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T225 37981-37999 Body_part denotes epithelial tissues http://purl.org/sig/ont/fma/fma9639
T226 38242-38245 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T227 38822-38828 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T228 38986-38992 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T229 39009-39021 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T230 39080-39088 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T231 39917-39925 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T232 40050-40053 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T233 40183-40191 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T234 41083-41087 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T235 41199-41203 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T236 41436-41444 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T237 41493-41497 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T238 41748-41754 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T239 41786-41793 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T240 41798-41803 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T241 42095-42103 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T242 42122-42127 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T243 43413-43421 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542
T244 44422-44430 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1969-1974 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T2 2483-2501 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T3 2568-2572 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T4 2714-2720 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 2753-2756 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T6 2773-2776 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T7 4699-4702 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T8 4764-4771 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T9 5489-5495 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T10 5684-5690 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T11 10305-10309 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T12 10608-10614 Body_part denotes embryo http://purl.obolibrary.org/obo/UBERON_0000922
T13 10885-10891 Body_part denotes embryo http://purl.obolibrary.org/obo/UBERON_0000922
T14 13122-13125 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T15 13544-13550 Body_part denotes embryo http://purl.obolibrary.org/obo/UBERON_0000922
T16 14482-14486 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T17 14492-14498 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T18 14516-14522 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T19 14788-14791 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T20 15733-15739 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T21 16532-16535 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T22 17383-17386 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T23 17575-17579 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 17585-17591 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T25 18862-18868 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 19476-19482 Body_part denotes embryo http://purl.obolibrary.org/obo/UBERON_0000922
T27 20000-20006 Body_part denotes embryo http://purl.obolibrary.org/obo/UBERON_0000922
T28 20827-20830 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T29 21919-21924 Body_part denotes mucus http://purl.obolibrary.org/obo/UBERON_0000912
T30 21959-21966 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T31 22016-22022 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T32 22358-22364 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T33 22910-22916 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T34 23001-23008 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T35 23164-23173 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T36 23448-23454 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T37 23597-23604 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T38 23668-23675 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T39 23788-23794 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T40 24107-24113 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T41 24208-24215 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T42 24364-24371 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T43 24468-24475 Body_part denotes Trachea http://purl.obolibrary.org/obo/UBERON_0003126
T44 24518-24522 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T45 24585-24591 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T46 24715-24720 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T47 24773-24777 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T48 24783-24789 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T49 24945-24951 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T50 25098-25104 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T51 25151-25158 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T52 25372-25376 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T53 25599-25605 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T54 25727-25733 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T55 26058-26064 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T56 28428-28434 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T57 29696-29701 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T58 29796-29801 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T59 32452-32457 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T60 32578-32584 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T61 34417-34423 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T62 34519-34526 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T63 34528-34532 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T64 34538-34544 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T65 34568-34574 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T66 34640-34644 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T67 35253-35259 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T68 35463-35470 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T69 35760-35766 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T70 35881-35887 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T71 36122-36129 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T72 36265-36272 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T73 36531-36537 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T74 36867-36874 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T75 36875-36885 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T76 36941-36947 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T77 38683-38686 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T78 38822-38828 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T79 38986-38992 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T80 39988-39994 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T81 41253-41259 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T82 41748-41754 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T83 42122-42127 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 12-22 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T2 23-33 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T3 608-618 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T4 619-629 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T5 647-657 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T6 658-671 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T7 2198-2208 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T8 2209-2219 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T9 2250-2269 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T10 2339-2352 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T11 2546-2556 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T12 2734-2743 Disease denotes nephritis http://purl.obolibrary.org/obo/MONDO_0001166
T13 2841-2851 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T14 2852-2862 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T15 3617-3627 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T16 4238-4247 Disease denotes nephritis http://purl.obolibrary.org/obo/MONDO_0001166
T17 4553-4569 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T18 5213-5222 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T19 5503-5505 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T20 5711-5734 Disease denotes bacterial infections in http://purl.obolibrary.org/obo/MONDO_0005113
T21 8421-8431 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T22 13445-13455 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T23 13551-13561 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T24 14173-14180 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T25 14340-14349 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 14367-14376 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 14540-14555 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T28 14546-14555 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 21076-21085 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 23618-23627 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T31 23935-23944 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 24701-24713 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T33 25394-25403 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 26479-26488 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 29187-29189 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T36 34672-34681 Disease denotes nephritis http://purl.obolibrary.org/obo/MONDO_0001166
T37 34793-34802 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 36147-36156 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 36397-36406 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 38026-38035 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 38083-38096 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T42 38492-38501 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 40496-40505 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 42339-42348 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 74-76 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T2 77-81 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T3 289-291 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T4 362-364 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T5 365-369 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T6 476-478 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T7 506-507 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 638-639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 735-736 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T10 764-765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 900-902 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T12 913-914 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 998-1000 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T14 1001-1005 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T15 1122-1129 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T16 1130-1137 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T17 1183-1190 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T18 1259-1264 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T19 1422-1427 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T20 1431-1438 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T21 1431-1438 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T22 1431-1438 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T23 1448-1456 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T24 1479-1481 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T25 1608-1610 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T26 1866-1874 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T27 1897-1899 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T28 1988-1990 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T29 2005-2012 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T30 2108-2110 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T31 2129-2130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 2248-2249 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 2453-2454 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 2483-2501 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T35 2568-2572 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
T36 2568-2572 http://www.ebi.ac.uk/efo/EFO_0000964 denotes head
T37 2635-2640 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 2687-2697 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T39 2714-2720 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T40 2714-2720 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T41 2714-2720 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T42 2725-2731 http://purl.obolibrary.org/obo/UBERON_0000991 denotes gonads
T43 2863-2868 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T44 2876-2877 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 2929-2934 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T46 3270-3272 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T47 3277-3279 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T48 3277-3279 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T49 3303-3305 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T50 3306-3308 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T51 3306-3308 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T52 3328-3330 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T53 3414-3419 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54 3429-3431 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T55 3429-3431 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T56 3451-3459 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T57 3657-3660 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T58 3794-3796 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T59 3797-3801 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T60 4128-4132 http://purl.obolibrary.org/obo/CLO_0054064 denotes 4/91
T61 4214-4216 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T62 4306-4314 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T63 4367-4368 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 4437-4438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 4748-4756 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T66 4823-4824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 5017-5021 http://purl.obolibrary.org/obo/CLO_0054064 denotes 4/91
T68 5226-5234 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T69 5276-5278 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T70 5303-5306 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T71 5481-5488 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T72 5489-5495 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T73 5489-5495 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T74 5489-5495 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T75 5496-5501 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T76 5635-5637 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T77 5803-5810 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T78 5903-5904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 6050-6055 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T80 6057-6059 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T81 6084-6085 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 6124-6125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 6698-6703 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T84 6923-6925 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T85 6945-6950 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T86 6995-6997 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T87 7084-7086 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T88 7092-7097 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T89 7229-7236 http://purl.obolibrary.org/obo/CLO_0001409 denotes 5], [28
T90 7282-7283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 7344-7346 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T92 7411-7413 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93 7414-7418 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T94 7632-7640 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T95 7716-7723 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T96 7761-7762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 7963-7964 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 7991-7992 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 8127-8128 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 8196-8198 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T101 8202-8204 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T102 8222-8229 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T103 8270-8277 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T104 8278-8285 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T105 8337-8343 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T106 8413-8420 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Chicken
T107 8573-8581 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T108 8595-8602 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T109 8603-8610 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T110 8662-8663 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 8697-8705 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T112 8845-8847 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T113 8866-8868 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T114 9045-9057 http://purl.obolibrary.org/obo/CLO_0053891 denotes BHK-21 cells
T115 9084-9086 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T116 9090-9092 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T117 9099-9103 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T118 9193-9200 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T119 9201-9208 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T120 9394-9398 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T121 9417-9418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 9445-9447 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T123 9453-9454 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T124 9480-9482 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T125 9610-9614 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T126 9777-9779 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T127 9871-9873 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T128 9871-9873 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T129 9967-9968 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 9980-9984 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T131 9987-9988 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T132 10056-10058 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T133 10063-10066 http://purl.obolibrary.org/obo/CLO_0050884 denotes Ten
T134 10189-10198 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T135 10219-10220 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 10278-10281 http://purl.obolibrary.org/obo/CLO_0009364 denotes TM1
T137 10287-10288 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 10305-10309 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T139 10431-10435 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T140 10503-10505 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T141 10600-10607 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Chicken
T142 10608-10614 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
T143 10675-10682 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T144 10683-10690 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T145 10725-10727 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T146 10731-10736 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 10807-10815 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavities
T148 10851-10858 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T149 10885-10891 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
T150 10987-10994 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T151 10995-11002 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T152 11042-11049 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T153 11050-11057 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T154 11059-11060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 11456-11457 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T156 11511-11512 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T157 11613-11617 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T158 11732-11734 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T159 11762-11769 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T160 11837-11839 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T161 11846-11847 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 12044-12046 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T163 12052-12054 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T164 12056-12058 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T165 12275-12276 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 12717-12722 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T167 12799-12806 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T168 12876-12881 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T169 12915-12917 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T170 13000-13006 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T171 13037-13044 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T172 13084-13089 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T173 13183-13184 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T174 13209-13210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 13237-13244 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T176 13299-13306 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T177 13372-13377 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T178 13384-13385 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 13418-13425 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T180 13544-13550 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
T181 13653-13660 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T182 13716-13724 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T183 13729-13737 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T184 13847-13848 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T185 13878-13886 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T186 13950-13961 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens in
T187 14104-14106 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T188 14439-14447 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T189 14482-14486 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T190 14482-14486 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T191 14492-14498 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T192 14492-14498 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T193 14492-14498 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T194 14564-14565 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T195 14593-14601 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T196 14756-14758 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T197 14788-14791 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T198 14928-14933 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T199 14935-14942 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T200 14935-14942 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T201 14935-14942 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T202 15007-15011 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T203 15013-15017 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T204 15227-15228 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 15477-15482 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T206 15623-15625 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T207 15653-15661 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T208 15790-15794 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T209 15821-15826 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T210 15828-15835 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T211 15828-15835 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T212 15828-15835 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T213 15889-15897 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T214 16440-16442 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T215 16532-16535 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T216 16646-16648 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T217 16650-16652 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T218 16798-16803 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 16977-16979 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T220 17048-17056 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T221 17094-17102 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T222 17175-17177 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T223 17192-17193 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T224 17288-17299 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens in
T225 17383-17386 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T226 17527-17535 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T227 17575-17579 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T228 17575-17579 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T229 17585-17591 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T230 17585-17591 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T231 17585-17591 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T232 17684-17686 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T233 17701-17709 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T234 17804-17806 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T235 17821-17822 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 17930-17936 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T237 17967-17975 http://purl.obolibrary.org/obo/PR_000001438 denotes lab at 7
T238 18108-18109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 18110-18114 http://purl.obolibrary.org/obo/CLO_0009524 denotes vero
T240 18110-18114 http://purl.obolibrary.org/obo/CLO_0050515 denotes vero
T241 18115-18120 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T242 18206-18213 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T243 18371-18378 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T244 18640-18641 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 18839-18843 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T246 18897-18901 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T247 18942-18943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 18989-18990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 19158-19167 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T250 19248-19250 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T251 19346-19353 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T252 19395-19403 http://purl.obolibrary.org/obo/NCBITaxon_32524 denotes amniotic
T253 19404-19412 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T254 19476-19482 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
T255 19489-19492 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2 A
T256 19512-19517 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T257 19612-19614 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T258 19782-19789 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T259 19790-19797 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T260 19800-19801 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T261 19855-19862 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T262 19896-19903 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T263 19947-19952 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T264 19987-19989 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T265 20000-20006 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
T266 20066-20067 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T267 20124-20126 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T268 20137-20144 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T269 20247-20249 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T270 20260-20267 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T271 20539-20541 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T272 20568-20577 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T273 20627-20628 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 20691-20692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 20817-20822 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T276 20904-20906 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T277 20912-20914 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T278 20916-20918 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T279 21031-21032 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 21062-21064 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T281 21124-21126 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T282 21313-21321 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T283 21404-21409 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T284 21451-21459 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T285 21513-21514 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T286 21547-21558 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens in
T287 21617-21625 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T288 21893-21907 http://purl.obolibrary.org/obo/UBERON_0001008 denotes urinary system
T289 21893-21907 http://www.ebi.ac.uk/efo/EFO_0000803 denotes urinary system
T290 22016-22022 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T291 22016-22022 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T292 22016-22022 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T293 22066-22071 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T294 22154-22156 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T295 22196-22204 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T296 22283-22291 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T297 22313-22321 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T298 22358-22364 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T299 22358-22364 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T300 22358-22364 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T301 22439-22441 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T302 22465-22466 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T303 22632-22634 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T304 22648-22649 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T305 22675-22683 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T306 22693-22697 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T307 22789-22791 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T308 22820-22821 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T309 22844-22849 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T310 22854-22861 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T311 22854-22861 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T312 22854-22861 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T313 22878-22886 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T314 22935-22943 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T315 23065-23075 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T316 23076-23080 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T317 23137-23140 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 C
T318 23198-23203 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T319 23240-23251 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocyte
T320 23269-23273 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T321 23359-23370 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocyte
T322 23448-23454 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T323 23448-23454 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T324 23448-23454 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T325 23475-23483 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T326 23523-23531 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T327 23554-23556 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T328 23643-23647 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T329 23701-23711 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T330 23712-23717 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T331 23759-23764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T332 23788-23794 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T333 23863-23868 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T334 23873-23880 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T335 23873-23880 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T336 23873-23880 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T337 23900-23902 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T338 23915-23923 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T339 24137-24145 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T340 24159-24163 http://purl.obolibrary.org/obo/UBERON_0003064 denotes I, M
T341 24217-24222 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T342 24224-24231 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T343 24224-24231 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T344 24224-24231 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T345 24250-24258 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T346 24313-24315 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T347 24327-24331 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T348 24426-24431 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T349 24502-24506 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T350 24512-24513 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T351 24518-24522 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T352 24518-24522 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T353 24585-24591 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T354 24585-24591 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T355 24585-24591 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T356 24650-24657 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T357 24650-24657 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T358 24650-24657 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T359 24773-24777 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T360 24773-24777 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T361 24783-24789 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T362 24783-24789 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T363 24783-24789 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T364 25004-25006 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T365 25098-25104 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T366 25208-25210 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T367 25324-25328 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T368 25372-25376 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T369 25372-25376 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T370 25465-25470 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T371 25484-25486 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T372 25599-25605 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T373 25599-25605 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T374 25599-25605 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T375 25648-25652 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T376 25693-25695 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T377 25727-25733 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T378 25727-25733 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T379 25727-25733 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T380 25752-25760 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T381 25774-25783 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T382 25869-25871 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T383 25888-25892 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T384 26058-26064 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T385 26065-26069 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T386 26071-26075 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T387 26094-26102 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T388 26165-26167 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T389 26171-26175 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T390 26251-26260 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T391 26310-26311 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T392 26374-26375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T393 26564-26565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T394 26677-26679 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T395 26714-26722 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T396 26743-26745 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T397 26758-26766 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T398 26887-26889 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T399 26941-26942 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T400 27070-27072 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T401 27168-27170 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T402 27218-27220 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T403 27239-27244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T404 27327-27329 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T405 27331-27333 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T406 27379-27387 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T407 27442-27444 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T408 27544-27553 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T409 27603-27604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T410 27813-27821 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T411 27832-27834 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T412 27956-27958 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T413 28065-28066 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T414 28082-28090 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T415 28234-28242 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T416 28402-28409 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T417 28428-28434 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T418 28428-28434 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T419 28428-28434 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T420 28509-28516 http://purl.obolibrary.org/obo/UBERON_0000056 denotes ureters
T421 28533-28541 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T422 28564-28566 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T423 28575-28586 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens in
T424 28657-28658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T425 28819-28821 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T426 28836-28837 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T427 28874-28882 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T428 28999-29007 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T429 29034-29036 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T430 29049-29050 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T431 29082-29089 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T432 29082-29089 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T433 29082-29089 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T434 29108-29116 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T435 29427-29429 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T436 29447-29448 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 29738-29746 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T438 29757-29759 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T439 29774-29782 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T440 30340-30342 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T441 30441-30446 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T442 30495-30497 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T443 31246-31248 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T444 31252-31254 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T445 31298-31303 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T446 31498-31503 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T447 31513-31515 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T448 31519-31527 http://purl.obolibrary.org/obo/CLO_0001013 denotes 46], [47
T449 31519-31527 http://purl.obolibrary.org/obo/CLO_0052464 denotes 46], [47
T450 31547-31548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T451 31716-31723 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T452 31795-31797 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T453 31798-31802 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T454 31878-31880 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T455 31940-31942 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T456 31943-31947 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T457 32099-32100 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T458 32119-32121 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T459 32182-32184 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T460 32185-32189 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T461 32221-32222 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T462 32299-32301 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T463 32305-32307 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T464 32344-32345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T465 32444-32445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T466 32458-32465 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T467 32525-32533 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Chickens
T468 32578-32584 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T469 32578-32584 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T470 32578-32584 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T471 32596-32597 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T472 32651-32654 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T473 32738-32740 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T474 32741-32745 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T475 32842-32843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T476 32967-32969 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T477 32970-32972 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T478 32970-32972 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T479 33109-33110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T480 33405-33407 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T481 33408-33412 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T482 33685-33689 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T483 33767-33777 http://purl.obolibrary.org/obo/CLO_0001410 denotes 52]. The S
T484 33806-33808 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T485 33813-33815 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T486 33813-33815 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T487 33832-33834 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T488 33835-33837 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T489 33835-33837 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T490 33862-33864 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T491 33921-33926 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T492 33945-33947 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T493 33948-33952 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T494 33953-33956 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T495 33991-33996 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T496 34054-34056 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T497 34075-34077 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T498 34078-34082 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T499 34124-34126 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T500 34127-34129 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T501 34127-34129 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T502 34220-34227 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T503 34253-34255 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T504 34346-34356 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T505 34357-34362 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T506 34417-34423 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T507 34417-34423 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T508 34417-34423 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T509 34425-34431 http://purl.obolibrary.org/obo/UBERON_0000991 denotes gonads
T510 34528-34532 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T511 34528-34532 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T512 34538-34544 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T513 34538-34544 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T514 34538-34544 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T515 34640-34644 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T516 34640-34644 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T517 34707-34711 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T518 34754-34762 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T519 34880-34890 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T520 34972-34977 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T521 35013-35017 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T522 35050-35052 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T523 35102-35107 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T524 35120-35124 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T525 35170-35172 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T526 35170-35172 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T527 35192-35200 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T528 35282-35284 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T529 35374-35376 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T530 35420-35422 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T531 35531-35536 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T532 35574-35579 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T533 35584-35591 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T534 35584-35591 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T535 35584-35591 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T536 35604-35616 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens, in
T537 35629-35637 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T538 35706-35708 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T539 35706-35708 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T540 35713-35715 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T541 35716-35721 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T542 35881-35887 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T543 35881-35887 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T544 35881-35887 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T545 35904-35906 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T546 35965-35967 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T547 35965-35967 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T548 35968-35972 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T549 36244-36249 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T550 36273-36283 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T551 36284-36289 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T552 36875-36885 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T553 36941-36947 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T554 36951-36959 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T555 36980-36982 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T556 37075-37083 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T557 37144-37146 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T558 37391-37393 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T559 37487-37489 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T560 37500-37505 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T561 37510-37517 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T562 37510-37517 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T563 37510-37517 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T564 37607-37609 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T565 37610-37614 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T566 37634-37639 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T567 37843-37846 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T568 37925-37927 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T569 37928-37933 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T570 37981-37999 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelial tissues
T571 38097-38104 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T572 38160-38161 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T573 38299-38307 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T574 38318-38320 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T575 38322-38324 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T576 38449-38451 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T577 38549-38552 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T578 38587-38592 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T579 38663-38665 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T580 38694-38702 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T581 38736-38737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T582 38784-38789 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T583 38864-38871 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T584 38879-38881 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T585 38903-38904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T586 38949-38957 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T587 39006-39008 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T588 39027-39030 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T589 39065-39066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T590 39139-39141 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T591 39195-39199 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T592 39331-39339 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T593 39393-39395 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T594 39543-39544 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T595 39768-39770 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T596 39888-39896 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T597 39988-39994 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T598 40201-40209 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T599 40236-40238 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T600 40652-40654 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T601 40725-40727 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T602 40742-40749 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T603 40823-40824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T604 40825-40832 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T605 40872-40874 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T606 40872-40874 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T607 40945-40947 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T608 40945-40947 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T609 41046-41048 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T610 41046-41048 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T611 41083-41087 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T612 41141-41143 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T613 41199-41203 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T614 41253-41259 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T615 41278-41286 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T616 41406-41408 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T617 41490-41492 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T618 41493-41497 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T619 41786-41793 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T620 41786-41793 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T621 41786-41793 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T622 41798-41803 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T623 41816-41823 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T624 41857-41865 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T625 41956-41958 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T626 42072-42080 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T627 42146-42154 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T628 42220-42222 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T629 42244-42245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T630 42382-42389 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T631 42428-42434 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T632 42548-42554 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T633 43422-43423 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T634 44270-44276 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T635 44431-44432 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 66-73 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 1309-1314 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T3 1353-1358 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T4 1678-1683 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T5 3115-3123 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T6 3140-3148 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T7 3170-3178 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T8 3246-3253 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 3277-3279 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T10 3306-3308 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T11 3331-3338 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 3429-3431 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T13 3768-3778 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T14 3768-3773 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T15 3774-3778 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T16 8043-8048 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T17 8265-8268 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T18 8355-8357 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T19 8569-8572 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T20 8591-8594 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T21 8773-8778 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T22 9189-9192 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T23 9871-9873 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T24 10292-10302 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T25 10847-10850 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T26 11758-11761 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T27 11785-11790 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T28 12031-12036 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T29 12483-12485 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T30 13033-13036 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T31 13090-13098 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T32 13712-13715 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T33 13816-13821 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T34 13874-13877 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T35 13938-13943 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T36 14131-14136 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T37 14589-14592 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
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T50 17880-17885 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T51 18051-18058 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T52 18396-18404 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T53 18580-18585 Chemical denotes H2SO4 http://purl.obolibrary.org/obo/CHEBI_26836
T54 18586-18594 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T55 18764-18766 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T56 19364-19369 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57 19778-19781 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T58 19892-19895 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T59 19913-19918 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T60 20133-20136 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T61 20256-20259 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T62 20343-20345 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T63 20523-20528 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64 20545-20550 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 20851-20856 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T66 21309-21312 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T67 21391-21396 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T68 21447-21450 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T69 21489-21494 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
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T71 21992-21997 Chemical denotes urate http://purl.obolibrary.org/obo/CHEBI_17775
T72 22568-22573 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 22671-22674 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T74 23516-23521 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T75 24246-24249 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T76 25214-25219 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77 25313-25318 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T78 25490-25495 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T79 25572-25574 Chemical denotes 5B http://purl.obolibrary.org/obo/CHEBI_27560
T80 25875-25880 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T81 26090-26093 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T82 26628-26633 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T83 26867-26872 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T84 27006-27011 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 27174-27179 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 27273-27278 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T87 27809-27812 Chemical denotes SPF http://purl.obolibrary.org/obo/CHEBI_88542
T88 27838-27843 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
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T90 28473-28478 Chemical denotes urate http://purl.obolibrary.org/obo/CHEBI_17775
T91 28612-28617 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
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T93 28763-28768 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T94 32844-32854 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T95 32923-32933 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T96 32923-32928 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T97 32929-32933 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T98 32970-32972 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T99 33537-33544 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 33575-33583 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T101 33778-33785 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T102 33813-33815 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T103 33835-33837 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T104 34127-34129 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T105 34994-35005 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T106 35001-35005 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T107 35170-35172 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T108 35389-35394 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T109 35706-35708 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T110 35965-35967 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T111 36629-36637 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T112 36687-36695 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
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T114 37769-37776 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 37809-37811 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
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T117 38455-38460 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T118 39009-39021 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
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T126 41046-41048 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1139-1145 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T2 3389-3419 http://purl.obolibrary.org/obo/GO_0019062 denotes viral attachment to host cells
T3 3451-3466 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T4 4553-4569 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T5 6704-6713 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T6 6704-6713 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T7 6867-6880 http://purl.obolibrary.org/obo/GO_0044409 denotes host invasion
T8 8547-8555 http://purl.obolibrary.org/obo/GO_0035188 denotes hatching
T9 10968-10974 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T10 11024-11030 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11 11071-11092 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T12 11079-11092 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13 11898-11904 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14 12247-12268 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T15 12255-12268 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T16 14523-14530 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T17 14540-14555 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T18 15199-15220 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T19 15207-15220 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T20 16239-16253 http://purl.obolibrary.org/obo/GO_0019076 denotes Viral shedding
T21 16280-16294 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T22 16887-16908 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T23 16895-16908 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T24 18845-18851 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T25 18869-18876 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T26 18882-18896 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T27 19443-19449 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T28 20182-20188 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T29 20740-20746 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T30 20988-20994 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T31 23046-23054 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T32 23046-23054 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T33 23046-23054 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T34 23046-23054 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T35 24391-24399 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T36 24391-24399 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T37 24391-24399 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T38 24391-24399 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T39 24701-24713 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T40 24753-24759 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T41 24827-24844 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T42 24827-24844 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T43 25717-25723 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T44 30775-30784 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T45 30775-30784 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T46 31424-31433 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T47 31424-31433 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T48 33974-33983 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T49 33974-33983 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T50 34295-34304 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T51 34295-34304 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T52 34505-34511 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T53 34621-34629 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T54 34621-34629 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T55 34621-34629 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T56 34621-34629 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T57 35158-35165 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T58 35192-35207 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T59 35260-35267 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T60 35489-35497 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T61 35489-35497 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T62 35489-35497 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T63 35489-35497 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T64 35767-35774 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T65 35849-35866 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T66 35849-35866 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T67 36498-36507 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T68 36498-36507 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T69 36551-36568 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T70 36551-36568 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T71 36838-36846 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T72 36838-36846 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T73 36838-36846 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T74 36838-36846 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T75 37193-37200 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T76 37971-37977 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T77 38683-38693 http://purl.obolibrary.org/obo/GO_0018991 denotes egg-laying
T78 38759-38768 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T79 38759-38768 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T80 38993-39000 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T81 39959-39976 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T82 39959-39976 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T83 40114-40129 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T84 40614-40638 http://purl.obolibrary.org/obo/GO_0002456 denotes cellular immune response
T85 40614-40638 http://purl.obolibrary.org/obo/GO_0002449 denotes cellular immune response
T86 40614-40638 http://purl.obolibrary.org/obo/GO_0002443 denotes cellular immune response
T87 40623-40638 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T88 41088-41095 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T89 42095-42114 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T90 44354-44368 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes Recombinant infectious bronchitis coronavirus H120 with the spike protein S1 gene of the nephropathogenic IBYZ strain remains attenuated but induces protective immunity
T2 170-180 Sentence denotes Highlights
T3 181-264 Sentence denotes • The reverse genetic operating systems of IBV H120 and IBYZ strains were created.
T4 265-445 Sentence denotes • We constructed rH120-S1/YZ strain, based on the backbone of the H120 vaccine strain, with the S1 gene replaced with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011.
T5 446-597 Sentence denotes • We demonstrated that rH120-S1/YZ had the potential to be a candidate vaccine strain for the prevention and control of the epidemic of renal strains.
T6 599-607 Sentence denotes Abstract
T7 608-734 Sentence denotes Infectious bronchitis (IB) is a highly infectious viral disease responsible for major economic losses in the poultry industry.
T8 735-839 Sentence denotes A reverse genetic vaccine is a safe, rapid, and effective method of achieving IB prevention and control.
T9 840-1100 Sentence denotes In this study, we constructed the recombinant strain, rH120-S1/YZ, using a reverse genetic system, based on the backbone of the H120 vaccine strain, with the S1 gene replaced with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011, isolated in China.
T10 1101-1284 Sentence denotes The results of dwarf chicken embryos, growth kinetics, and viral titration in the embryos demonstrated that the biological characteristics of the recombinant virus remained unchanged.
T11 1285-1485 Sentence denotes Like the rH120-infected group and in contrast to the rIBYZ-infected group, no mortality, clinical signs, or lesions were observed in the lungs or kidneys of young chickens inoculated with rH120-S1/YZ.
T12 1486-1647 Sentence denotes The viral loads in various tissues, cloacal, and oral swabs was lower in most types of samples, indicating that the rH120-S1/YZ strain was highly safe in chicks.
T13 1648-1903 Sentence denotes Compared to rH120 vaccination group, when the efficacy of this strain was evaluated against the QX-like IBV strain, better protection, with 100% survival rate and no disease symptom or gross lesion was observed in the chickens vaccinated with rH120-S1/YZ.
T14 1904-2038 Sentence denotes Increased levels of IBV-specific antibodies were detected in the serum of the rH120-S1/YZ-vaccinated animals 14 days post-vaccination.
T15 2039-2180 Sentence denotes Collectively, our results suggest that the recombinant strain, rH120-S1/YZ, may represent a promising vaccine candidate against QX-like IBVs.
T16 2182-2197 Sentence denotes 1 Introduction
T17 2198-2449 Sentence denotes Infectious bronchitis (IB) was first described as a respiratory disease affecting chicks in the US in 1931 as an acute and highly contagious viral disease, and continues to cause major economic loss within the poultry industry worldwide [1], [2], [3].
T18 2450-2624 Sentence denotes As a result of the damage to the respiratory system, the clinical signs of this disease include depression, coughing, head-shaking, as well as nasal and ocular discharge [1].
T19 2625-2811 Sentence denotes Since the virus causing IB replicates in many non-respiratory epithelial surfaces (e.g., kidney and gonads), nephritis, reduced egg production, and egg quality is also observed [2], [3].
T20 2812-3032 Sentence denotes The causative agent of IB is infectious bronchitis virus (IBV), a non-segmented, positive-sense, single-stranded RNA virus, which belongs to the genus Gammacoronavirus, family Coronaviridae, in the order Nidovirales [4].
T21 3033-3239 Sentence denotes The full length RNA genome of IBV is 27.6 kb in length and encodes non-structural proteins, four accessory proteins, and four structural proteins (spike [S], matrix [M], nucleocapsid [N], and envelope [E]).
T22 3240-3323 Sentence denotes The S protein is cleaved into S1 and S2 as two subunits at the S1/S2 cleavage site.
T23 3324-3476 Sentence denotes The S1 protein contains the receptor-binding domain and mediates viral attachment to host cells, whereas S2 is responsible for membrane fusion [5], [6].
T24 3477-3716 Sentence denotes Errors generated during the genomic replication of IBV and the selective pressure following the use of live attenuated vaccines or multiple infections with different IBV serotypes has led to the emergence of numerous IBV variants [7], [8].
T25 3717-3881 Sentence denotes In particular, small change as little as 5% in the amino acid composition of S1 gene may lead to alteration in cross protection among closely related serotypes [9].
T26 3882-3993 Sentence denotes In China, IBV was first observed during the early 1980s, and outbreaks have since been frequently reported [7].
T27 3994-4230 Sentence denotes The QX-like genotype is thought to have originated during the mid-1990s and continues to be the predominant strain, whereas the LDT3, 4/91, and Taiwan subtypes have also recently been frequently isolated in China [10], [11], [12], [13].
T28 4231-4430 Sentence denotes Severe nephritis, false layer syndrome, and high mortality are observed in chickens infected with this viral genotype, which represents a major problem in the poultry industry, particularly in China.
T29 4431-4575 Sentence denotes Using a live attenuated or inactivated vaccine is typically considered to be the most cost-effective means of controlling viral infections [14].
T30 4576-4926 Sentence denotes Unfortunately, inactivated IB vaccines are not effective if used alone, which could induce little or no protection against egg loss [15], [16], as well as impaired ciliary activity in the trachea [17]; thus, birds must continue to be given one or a series of vaccinations with live attenuated IB vaccines to provide broad heterologous protection [1].
T31 4927-5286 Sentence denotes Commercial attenuated live vaccines used against IBV in China include the H120, LDT3, and 4/91 strains [7]; however, phylogenetic analysis indicates that the QX-like genotype is genetically distant from the strains described above, which may explain the poor cross-protectivity against infection in chickens immunized with these classical vaccines [18], [19].
T32 5287-5392 Sentence denotes Recently, there has been increasing research on live attenuated vaccines against the QX-like IBV strains.
T33 5393-5651 Sentence denotes Different strains of QX-like IBVs were serially passaged in embryonated eggs or primary chicken kidney cells (CK) to obtain vaccines that are less virulent and exhibit high immunogenicity against the QX-like epidemic IBV strains [20], [21], [22], [23], [24].
T34 5652-5929 Sentence denotes However, in addition to causing tissue damage or secondary bacterial infections in young vaccinated chicks [25], [26], live attenuated vaccines of RNA viruses may not be genetically stable or they may be associated with the tendency to revert back to a virulent form [9], [14].
T35 5930-6061 Sentence denotes Moreover, the potential for recombination between vaccine and virulent strains can lead to the creation of new virulent virus [27].
T36 6062-6310 Sentence denotes Furthermore, it takes a substantial amount of time to prepare a extensively passaged attenuated vaccine strain, which may not be able to effectively solved the loss problem caused by the rapid variation exhibited by prevalent strains on the flocks.
T37 6311-6523 Sentence denotes In considering the limitations of the live attenuated and inactivated IBV vaccines, reverse genetic IBV vaccines have been developed in recent years as they display increased safety and efficacy [28], [29], [30].
T38 6524-6835 Sentence denotes As reverse genetic technology is primarily based on the H120 and Beaudette strains [31], [32], [33], both of which are passage-generated attenuated strains, the mechanism of virus virulence attenuation remains unclear, thereby posing difficulties in the development of attenuated vaccines using this technology.
T39 6836-6999 Sentence denotes In addition to the function of host invasion and increasing genetic diversity, the IBV S1 subunit can induce virus neutralizing and cross-reactive antibodies [34].
T40 7000-7244 Sentence denotes Therefore, some researchers have created an attenuated IBV vaccine by replacing the S1 or S genes from other virulent strains using reverse genetic technology to generate protection against strains of the corresponding serotype [5], [28], [30].
T41 7245-7527 Sentence denotes In the present study, we constructed a recombinant strain, using the reverse genetic system. rH120-S1/YZ is based on the backbone of the vaccine strain H120, and the S1 gene was replaced with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011, which was isolated in China.
T42 7528-7671 Sentence denotes Our results demonstrate that this recombinant strain is safe and provides effective protection in young chickens against QX-like IBV challenge.
T43 7673-7697 Sentence denotes 2 Materials and methods
T44 7699-7723 Sentence denotes 2.1 Vaccine and viruses
T45 7724-7857 Sentence denotes The H120 vaccine strain is currently a widely used vaccine strain, created from 120 serial passages of the H strain isolated in 1956.
T46 7858-8084 Sentence denotes The ck/CH/IBYZ/2011 strain (referred to as IBYZ, GenBank KF663561.1) used in this study is classified as a QX-like IBV isolated from a flock presenting with IB symptoms by our research group in 2011 in Jiangsu Province, China.
T47 8085-8206 Sentence denotes Both of these strains were recovered from a full-length clone using reverse genetics, as previously described [35], [36].
T48 8208-8229 Sentence denotes 2.2 Eggs and animals
T49 8230-8542 Sentence denotes Fertilized specific pathogen free (SPF) chicken embryos were obtained from Beijing Merial Vital Laboratory Animal Technology Co., Ltd. (Beijing, China) and hatched in our lab (Lab of Chicken Infectious Disease Protection and Control, Poultry Institute, Chinese Academic of Agriculture Sciences, Yangzhou, China).
T50 8543-8692 Sentence denotes For hatching, one-day-old SPF chickens from the SPF chicken embryos as described previously were incubated at 37 °C in a relative humidity of 55–65%.
T51 8693-8804 Sentence denotes All chickens were maintained in isolators under negative pressure, and food and water were provided ad libitum.
T52 8806-8850 Sentence denotes 2.3 Construction of recombinant rH120-S1/YZ
T53 8851-8962 Sentence denotes The rIBV rH120-S1/YZ strain used in this study is described in the schematic illustration presented in Fig. 1 .
T54 8963-9094 Sentence denotes The genome RNA was synthesized in vitro by T7 RNA polymerase and transfected into BHK-21 cells, as previously described [35], [36].
T55 9095-9209 Sentence denotes The cell supernatants were harvested 48 h following transfection and propagated in 10-day-old SPF chicken embryos.
T56 9210-9329 Sentence denotes The allantoic fluid was harvested for RT-PCR, whole genome sequencing, and was then stored at −80 °C until further use.
T57 9330-9562 Sentence denotes Fig. 1 Schematic diagram for the construction of the chimeric S gene and production of a full-length cDNA of rH120-S1/YZ. (A) Replacement of the H120 S1 fragment by the corresponding sequence of IBYZ for construction of pYZS1H120S2.
T58 9563-9729 Sentence denotes The plasmids pIBYZS and pH120S contained the S gene of IBYZ strain and H120 strain, respectively, were constructed during the establishment of reverse genetic system.
T59 9730-9898 Sentence denotes Primers PS1F and PS1R were used to amplify the S1 fragment of IBYZ and vector fragment, while primers PS2F and PS2R were used to amplify the S2 fragment of H120 strain.
T60 9899-10062 Sentence denotes By overlapping PCR, the pYZS1H120S2 was constructed which contained a chimeric S gene. (B) Strategy for the construction of full-length cDNA clones of rH120-S1/YZ.
T61 10063-10148 Sentence denotes Ten cDNA fragments covering the entire genome of H120 strain was amplified by RT-PCR.
T62 10149-10351 Sentence denotes Unique Bsa I sites were inserted at the junctions between each clone, a unique T7 start site was inserted at the 5′ end of clone TM1, and a 28-nucleotide T tail was inserted at the 3′ end of clone TM10.
T63 10352-10436 Sentence denotes The S fragment in the pMDTM8 plasmid of H120 strain was replaced by chimeric S gene.
T64 10437-10593 Sentence denotes By using appropriate ligation strategy, the genomic cDNA of rH120-S1/YZ was assembled by in vitro ligation using appropriate restriction sites as indicated.
T65 10595-10626 Sentence denotes 2.4 Chicken embryo dwarf assay
T66 10627-10878 Sentence denotes To determine the recombinants’ pathogenicity in chicken embryos, 0.2 mL of rH120, rIBYZ, or rH120-S1/YZ virus (diluted to 1:100 in normal saline) was inoculated into the allantoic cavities of five 10-old-day embryonated SPF chicken eggs, respectively.
T67 10879-10961 Sentence denotes Chick embryo lesions were examined for lesions at 144 h post-inoculation at 37 °C.
T68 10963-11002 Sentence denotes 2.5 Growth kinetics in chicken embryos
T69 11003-11165 Sentence denotes To examine the viral growth ability in chicken embryos, a real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) method was established.
T70 11166-11277 Sentence denotes According to the sequences of IBV from GenBank, primers were designed based on conservative area in the 5′-UTR.
T71 11278-11388 Sentence denotes The upstream primer was 5′-CCGTTGCTTGGGCTACCTAGT-3′, and the downstream primer was 5′-CGCCTACCGCTAGATGAACC-3′.
T72 11389-11510 Sentence denotes The amplification product was cloned to pMD18-T vector (Takara) as a positive plasmid and its concentration was measured.
T73 11511-11618 Sentence denotes A gradient dilution of 5 × 102–5 × 108 copies/μL of the plasmid was used as template for quantitation test.
T74 11619-11731 Sentence denotes By plotting the cycle threshold (CT) values against the copies of the plasmid, the standard curve was generated.
T75 11732-11923 Sentence denotes 18 10-day-old embryonated SPF chicken eggs (six eggs/group) were inoculated with rH120, rIBYZ, and rH120-S1/YZ at a dose of 107 viral RNA copies/100 μL, and used for growth curve experiments.
T76 11924-12085 Sentence denotes The allantoic fluids were collected separately by syringe from the six inoculated embryonated eggs of each group at 12, 18, 24, 36, 48, 72, 96 h per inoculation.
T77 12086-12354 Sentence denotes RNA was extracted from the allantoic fluids using TRIzol Reagent (Invitrogen, Carlsbad, CA, USA) following the manufacturer’s instructions. cDNA was obtained by reverse transcription using a PrimeScript RT Master Mix Perfect Real Time Kit (TaKaRa, Otsu, Shiga, Japan).
T78 12355-12571 Sentence denotes The viral copies were measured by absolute quantitative method of Real-time PCR, which was performed using SYBR® Premix Ex Taq™ II (TaKaRa, Otsu, Shiga, Japan) on an Applied Biosystems 7500 Fast Real-time PCR System.
T79 12572-12647 Sentence denotes The standard curve was plotted against the log of the template copy number.
T80 12648-12770 Sentence denotes All of the assays were run in triplicate and the copy number of each virus was calculated according to the standard curve.
T81 12772-12806 Sentence denotes 2.6 Titration of rIBVs in embryos
T82 12807-13050 Sentence denotes Serial 10-fold dilutions from 105 copies to 109 copies per 0.1 mL of virus of the recombinant strain, rH120-S1/YZ, and its parental strains (rH120 and rIBYZ) were inoculated into the allantoic cavity of 10-day-old embryonated SPF chicken eggs.
T83 13051-13166 Sentence denotes For each dilution, 0.1 mL of the virus solution was injected into each egg and 10 eggs were used for each dilution.
T84 13167-13202 Sentence denotes PBS was used as a negative control.
T85 13203-13294 Sentence denotes After a 24 h incubation, the dead embryos were considered nonspecific deaths and discarded.
T86 13295-13403 Sentence denotes The embryos were examined for the presence of specific lesions caused by the virus after a 144-h incubation.
T87 13404-13535 Sentence denotes Dead and live embryos that displayed IBV infectious signs (e.g., dwarfing, curling, and stunting) were considered positive samples.
T88 13536-13639 Sentence denotes The 50% embryo infectious dose (EID50) of these rIBVs was calculated using the Reed-Muench method [37].
T89 13641-13660 Sentence denotes 2.7 Safety testing
T90 13662-13724 Sentence denotes 2.7.1 Assessment of pathogenicity in one-day-old SPF chickens
T91 13725-13846 Sentence denotes The chickens were separately housed in isolators under consistent conditions, and food and water was provided ad libitum.
T92 13847-13945 Sentence denotes A total of 120 one-day-old SPF chickens were randomly divided into four groups (n = 30 per group).
T93 13946-14118 Sentence denotes The chickens in the experimental groups were intranasally inoculated with 200 μL allantoic fluid per chick containing 105EID50 of the rH120, rIBYZ, and rH120-S1/YZ strains.
T94 14119-14204 Sentence denotes The control group (n = 30) was inoculated with 200 μL sterile PBS via the same route.
T95 14205-14261 Sentence denotes The morbidity and mortality was followed-up for 14 days.
T96 14262-14433 Sentence denotes All experimental groups were monitored daily for clinical signs related to IB infection for 14 days post-infection (dpi), including coughing, sneezing, and tracheal rales.
T97 14434-14507 Sentence denotes Dead chickens were examined for gross tracheal, lung, and kidney lesions.
T98 14509-14563 Sentence denotes 2.7.2 Tissue tropism of early viral infection in vivo
T99 14564-14650 Sentence denotes A total of 100 1-day-old SPF chickens were assigned to four groups (n = 25 per group).
T100 14651-14913 Sentence denotes The birds were inoculated with 200 μL allantoic fluid containing 105 EID50 of the rH120, rIBYZ, or rH120-S1/YZ strains, respectively via eye drop and the intranasal route and 200 μL PBS per chick was administered to the control group (n = 25) via the same route.
T101 14914-15099 Sentence denotes The tracheas, lungs, kidneys, and bursa from the 5 inoculated birds per group were harvested at 1, 3, 5, and 7 dpi, weighed, and collected into 1 mL PBS per sample and frozen at −80 °C.
T102 15100-15306 Sentence denotes After grinding the samples, the viral RNA was extracted using TRIzol, and the cDNA was obtained by reverse transcription using a PrimeScript RT Master Mix Perfect Real Time Kit (TaKaRa, Otsu, Shiga, Japan).
T103 15307-15413 Sentence denotes The viral RNA copies from each of the different samples were detected by real-time PCR as described above.
T104 15414-15530 Sentence denotes All assays were run in triplicate and the copy number for each virus was calculated according to the standard curve.
T105 15532-15553 Sentence denotes 2.7.3 Histopathology
T106 15554-15806 Sentence denotes After inoculation with 105 EID50 dose of the rH120, rIBYZ, and rH120-S1/YZ strains, three infected chickens per group were randomly selected to be euthanized by bleeding, and the tissue pathology was examined in the different groups at 3, 5, 7, 10 dpi.
T107 15807-16031 Sentence denotes The tracheas, lungs, kidneys, and bursas of three dead or other randomly-selected chickens from the experimental and control groups (inoculated with PBS) were collected at 5 or 7 dpi and further processed for histopathology.
T108 16032-16153 Sentence denotes The samples were fixed in formalin, embedded in paraffin, cut into 5 μm sections, and stained with hematoxylin and eosin.
T109 16154-16230 Sentence denotes The slides were examined under light microscopy for the presence of lesions.
T110 16232-16253 Sentence denotes 2.7.4 Viral shedding
T111 16254-16468 Sentence denotes To determine the level of viral shedding of the different recombinants, 10 birds per group were inoculated with 200 μL allantoic fluid containing 105 EID50 of the rH120, rIBYZ, or rH120-S1/YZ strains, respectively.
T112 16469-16568 Sentence denotes 200 μL PBS per chick was administered to the control group via eye drop and the intranasal route. .
T113 16569-16690 Sentence denotes Oral and cloacal swabs were collected from each bird into 1 mL PBS at 7, 14, 18, 22, 26, and 30 dpi and stored at −80 °C.
T114 16691-16952 Sentence denotes After freezing and thawing three times and centrifuging at 8,000 × g for 5 min at 4 °C, relative amount of virus present in 200 μL of supernatants of each sample was quantified by RNA extraction, reverse transcription, and real-time PCR as described previously.
T115 16954-16994 Sentence denotes 2.8 Efficacy of rH120-S1/YZ vaccination
T116 16996-17018 Sentence denotes 2.8.1 Viral challenge
T117 17019-17103 Sentence denotes In total, 30 one-day-old SPF chickens were divided into three groups of 10 chickens.
T118 17104-17255 Sentence denotes The three groups were intranasally vaccinated with the rH120 and rH120-S1/YZ strains at a dose of 104 EID50/200 μL, and the control group received PBS.
T119 17256-17417 Sentence denotes Two weeks post-vaccination, the chickens in each group were challenged with the QX-like strain, rIBYZ, at 106 EID50/200 μL via eye drop and the intranasal route.
T120 17418-17517 Sentence denotes Any clinical signs, as well as the percentage of morbidity and mortality were recorded for 14 days.
T121 17518-17600 Sentence denotes The dead chickens were also examined for gross tracheal, lung, and kidney lesions.
T122 17602-17683 Sentence denotes 2.8.2 Antibody response measured by an enzyme-linked immunosorbent assay (ELISA)
T123 17684-17760 Sentence denotes 45 1-day-old SPF chickens were divided into three groups (n = 15 per group).
T124 17761-18020 Sentence denotes After vaccinating with the rH120 and rH120-S1/YZ strains at a dose of 104 EID50/200 μL, the sera of 10 birds from each group were randomly collected and antibodies were tested using an ELISA created in our lab at 7, 14, 21, and 28 days post-vaccination (dpv).
T125 18021-18194 Sentence denotes ELISA plates were coated with antigen of culture supernatants of inactivated IBV rMJ , a vero cells adaption strain domesticated from its parental strain of IBYZ in our lab.
T126 18195-18330 Sentence denotes Individual chicken sera collected from different groups diluted to 1:200 were loaded and the plates were incubated at 37 °C for 60 min.
T127 18331-18473 Sentence denotes IBV-specific IgG was detected with anti-chicken IgY (IgG) (whole molecule)-peroxidase antibodies produced in rabbits (Sigma-Aldrich, Germany).
T128 18474-18685 Sentence denotes After incubated with 3,3′,5,5′-Tetramethylbenzidine(TMB) substrate for 15 min and terminated with 2 mol/L H2SO4 solution, the absorbance at 490 nm was measured using a Model 680 microplate reader (Bio-Rad, USA).
T129 18687-18712 Sentence denotes 2.9 Statistical analysis
T130 18713-18821 Sentence denotes GraphPad Prism 7 software (GraphPad Software Inc., La Jolla, CA, USA) was used for the statistical analyses.
T131 18822-19043 Sentence denotes For the antibody test, growth kinetics, tissue tropism, and viral shedding test, the collected data were analyzed using a two-way ANOVA to determine whether there was a significant difference between the different groups.
T132 19044-19199 Sentence denotes The significance was considered as follows: significant at P ≤ 0.05 (*); highly significant at P ≤ 0.01 (**); and extremely significant at P ≤ 0.001 (***).
T133 19201-19211 Sentence denotes 3 Results
T134 19213-19260 Sentence denotes 3.1 Characterization of the rH120-S1/YZ strain
T135 19261-19494 Sentence denotes After being inoculated with the recombinant strains, typical IB lesions in the chick embryos from each group were observed, including amniotic membrane thickening, dwarfing, stunted growth, curling, or death of the embryo (Fig. 2 A).
T136 19495-19569 Sentence denotes The EID50 of the virus was calculated according to the Reed-Muench method.
T137 19570-19723 Sentence denotes The titers of the rH120, rIBYZ, and rH120-S1/YZ strains were determined to be 107.3 EID50/mL, 106.8 EID50/mL, and 108.4 EID50/mL, respectively (Fig. 2B).
T138 19724-19863 Sentence denotes Fig. 2 The biological characteristics of the rIBVs in SPF chicken embryos. (A) Pathogenicity of recombinant IBVs in infected chick embryos.
T139 19864-19993 Sentence denotes Five 10-old-day embryonated SPF chicken eggs per group were inoculated with 0.2 mL virus diluent of rH120, rIBYZ, or rH120-S1/YZ.
T140 19994-20285 Sentence denotes Chick embryo lesions were observed at 144 h post-inoculation at 37 °C. (B) EID50 of the recombinant IBVs, rH120, rIBYZ, and rH120-S1/YZ in SPF chicken embryonated eggs. (C) The multicycle growth kinetics of the recombinant IBVs, rH120, rIBYZ, and rH120-S1/YZ in SPF chicken embryonated eggs.
T141 20286-20347 Sentence denotes All data are presented as the mean ± standard deviation (SD).
T142 20348-20396 Sentence denotes Some of the error bars are too small to be seen.
T143 20397-20447 Sentence denotes The qRT-PCR was carried out with three replicates.
T144 20448-20735 Sentence denotes Markers of statistical difference were acquired by comparing between rH120 group and rH120-S1/YZ group. ***Indicates an extremely significant difference at P ≤ 0.001; **Indicates a highly significant difference at 0.001 < P ≤ 0.01; *Indicates a significant difference at 0.01 < P ≤ 0.05.
T145 20736-20857 Sentence denotes The growth kinetics of the rIBVs were assessed by inoculation with 107 copies of virus per egg in 6 eggs from each group.
T146 20858-20983 Sentence denotes The relative viral load was determined at 12, 18, 24, 36, 48, 72, and 96 h post-inoculation by quantitative real-time RT-PCR.
T147 20984-21238 Sentence denotes The growth curves of all three strains reached a relatively stable plateau at 36–48 h after infection; the level of viral RNA for the rH120-S1/YZ strain was significantly higher than that of the rIBYZ strain for the majority of the time points (Fig. 2C).
T148 21240-21251 Sentence denotes 3.2 Safety
T149 21253-21321 Sentence denotes 3.2.1 Pathogenicity of the recombinants in one-day-old SPF chickens
T150 21322-21516 Sentence denotes The earliest death was observed at 3 dpi in the QX-like strain rIBYZ group, which virus was highly pathogenic to one-day-old SPF chickens; the final mortality of this group was 63.3% (Fig. 3 A).
T151 21517-21829 Sentence denotes The morbidity of the infected chickens in the rIBYZ group reached higher than 80%, and the diseased chickens exhibited respiratory symptoms (e.g., sneezing, coughing, as well as tracheal and bronchiolar rales), and the severe cases presented with additional signs of listlessness, huddling, and ruffled feathers.
T152 21830-22023 Sentence denotes At necropsy, lesions were detected both in the respiratory and urinary system, including mucus, hyperemia, and hemorrhage in the trachea, as well as swelling and urate deposition in the kidney.
T153 22024-22098 Sentence denotes Edema and congestion were observed in the lungs in 20% of cases (Fig. 3B).
T154 22099-22292 Sentence denotes However, following inoculation with the rH120 or rH120-S1/YZ strains, the morbidity rates of the chickens was less than 20%, with moderate respiratory signs of coughing in some of the chickens.
T155 22293-22468 Sentence denotes All of the infected chickens presented no visible lesions in the kidney and the survival rate was 100% through 14 dpi in both the rH120 and rH120-S1/YZ groups (Fig. 3A and B).
T156 22469-22574 Sentence denotes No obvious clinical signs, gross lesions, or death attributable to IBV was observed in the control group.
T157 22575-22746 Sentence denotes Fig. 3 Pathogenicity of the rIBV rH120, rIBYZ, and rH120-S1/YZ strains. (A) Percent survival of SPF chickens infected at 1-day-of age during the 14-day observation period.
T158 22747-22901 Sentence denotes No mortality was observed in rH120, rH120-S1/YZ, or the control groups. (B) Gross lesions on the lungs and kidneys of the infected chickens at 5 or 7 dpi.
T159 22903-22926 Sentence denotes 3.2.2 Tissue pathology
T160 22927-23142 Sentence denotes For the chickens inoculated with the QX-like strain rIBYZ, lesions in the trachea at 5 dpi were characterized as cilia necrosis and loss, epithelial cell congestion, hemorrhage, and lymphoid infiltration (Fig. 4 C).
T161 23143-23348 Sentence denotes In the bronchial and capillary lumen of rIBYZ-infected lungs, congestion, hemorrhage, as well as erythrocyte and inflammatory cell infiltration was observed in some severe cases from 7 to 10 dpi (Fig. 4G).
T162 23349-23494 Sentence denotes Moreover, erythrocyte and lymphocyte infiltration, as well as tubular dilation was observed in the kidney of rIBYZ-inoculated chickens (Fig. 4K).
T163 23495-23652 Sentence denotes Similar to the rH120 group, chickens inoculated with rH120-S1/YZ presented with mild pathology in the trachea at the early infection time points of 3, 5 dpi.
T164 23653-23811 Sentence denotes Lesions in the trachea consisted of the loss of epithelial cells and cilia, decreased number of secretory cells, and thickening of the mucosa (Fig. 4B and D).
T165 23812-23974 Sentence denotes In contrast, there were no lesions observed in the lungs and kidneys of rH120 and rH120-S1/YZ-infected chickens during the infection period (Fig. F, H, J, and L).
T166 23975-24167 Sentence denotes No histopathological evidence of damage was detected in the bursa of all the groups and no IBV-associated lesions were found in the tissue samples of the control chickens (Fig. 4A, E, I, M–P).
T167 24168-24343 Sentence denotes Fig. 4 Histopathological changes in the trachea, lungs, kidneys, and bursa of SPF chickens infected with the recombinant rH120, rIBYZ, and rH120-S1/YZ strains at 1-day-of-age.
T168 24344-24405 Sentence denotes Black arrows in the trachea indicate cilia and necrosis loss.
T169 24406-24467 Sentence denotes Black arrows in the lungs indicate congestion and hemorrhage.
T170 24468-24633 Sentence denotes Trachea samples were collected at 3, 5 dpi (A–D); lung and bursa samples were collected at 7, 10 dpi (E–H; M–P); and kidney samples were collected at 5, 7 dpi (I–L).
T171 24634-24714 Sentence denotes Black arrows in kidneys indicate tubular dilation, congestion, and inflammation.
T172 24715-24744 Sentence denotes Scale bar = 100 μm or 200 μm.
T173 24746-24797 Sentence denotes 3.2.3 Growth in tracheal, lung, and kidney tissues
T174 24798-24975 Sentence denotes The time-dependent levels of viral replication in the different tissues determined by real-time RT-PCR presented in Fig. 5 are consistent with the tissue histopathology results.
T175 24976-25159 Sentence denotes Compared to rH120 and rH120-S1/YZ groups, one day after inoculation with the QX-like strain, rIBYZ, the viral load in all organs began to rise rapidly, except at 5 dpi in the trachea.
T176 25160-25250 Sentence denotes The viral load in tracheal samples in the rH120-S1/YZ group increased and peaked at 5 dpi.
T177 25251-25353 Sentence denotes The level of viral RNA was significantly lower than the rH120 group both at 1 dpi and 7 dpi (Fig. 5A).
T178 25354-25576 Sentence denotes The viral load in lung samples from all infection groups increased starting at 3 dpi, and the viral RNA in the lungs of the rH120-S1/YZ group was significantly lower compared with both the rH120 and rIBYZ groups (Fig. 5B).
T179 25577-25657 Sentence denotes The viral load in the kidney of all IBV-inoculated groups was detected at 1 dpi.
T180 25658-25834 Sentence denotes In contrast to the rH120 and rH120-S1/YZ groups, the viral growth in kidney of rIBYZ-infected chickens exhibited an extremely significant increase at 3 dpi and peaked at 5 dpi.
T181 25835-25945 Sentence denotes The viral RNA copies of the rH120-S1/YZ group peaked at 1 dpi, after which they gradually decreased (Fig. 5C).
T182 25946-26022 Sentence denotes No viral load was detected in the control samples at any of the time points.
T183 26023-26187 Sentence denotes Fig. 5 Viral load in the different organs at 1, 3, 5, and 7 dpi of SPF chickens infected with the recombinant strains rH120, rIBYZ, and rH120-S1/YZ at 1-day-of age.
T184 26188-26418 Sentence denotes The bars indicate means ± standard deviations. ***Indicates an extremely significant difference at P ≤ 0.001; **Indicates a highly significant difference at 0.001 < P ≤ 0.01; *Indicates a significant difference at 0.01 < P ≤ 0.05.
T185 26420-26467 Sentence denotes 3.2.4 Viral load in the oral and cloacal swabs
T186 26468-26603 Sentence denotes In all IBV infection groups, the viral load in both the oral and cloacal swabs generally showed a gradual decline from 7 dpi to 26 dpi.
T187 26604-26944 Sentence denotes Compared with the rH120 group, The reduction in viral load between 14 or 18 dpi was significantly greater for chickens infected with rH120-S1/YZ than for chickens infected with rH120, and the viral RNA of the QX-like strain rIBYZ was lower than that of the rH120 group at 7, 14, and 18 dpi but with no statistically significance (Fig. 6 A).
T188 26945-27092 Sentence denotes In contrast, the viral load in the cloacal swab of the rIBYZ group was significantly higher than that of the rH120 and rH120-S1/YZ groups at 7 dpi.
T189 27093-27235 Sentence denotes Compared with other groups, the viral RNA in the cloacal swab of the rH120-S1/YZ group was significantly lower at 7, 14, and 22 dpi (Fig. 6B).
T190 27236-27297 Sentence denotes No virus was detected in the control group at any time point.
T191 27298-27456 Sentence denotes Fig. 6 Viral loads at 7, 14, 18, 22, and 26 dpi in the oral and cloacal swabs of chickens infected with the recombinant rH120, rIBYZ, and rH120-S1/YZ strains.
T192 27457-27709 Sentence denotes All data are presented as the mean ± standard error of the mean (SEM); ***Indicates an extremely significant difference at P ≤ 0.001; **Indicates a highly significant difference at 0.001 < P ≤ 0.01; *Indicates significant difference at 0.01 < P ≤ 0.05.
T193 27711-27732 Sentence denotes 3.3 Vaccine efficacy
T194 27734-27821 Sentence denotes 3.3.1 Efficacy of the different vaccines against QX-like IBV challenge in SPF chickens
T195 27822-27923 Sentence denotes The rH120-S1/YZ group exhibited effective protection against challenge with the QX-like strain rIBYZ.
T196 27924-28068 Sentence denotes The mortality rate in the rH120-S1/YZ group was 0%, and no clinical signs or lesions were observed during the rIBYZ challenge period (Fig. 7 A).
T197 28069-28379 Sentence denotes In contrast, chickens vaccinated with the rH120 strain began to exhibit clinical signs (e.g., coughing and nasal discharge) at 3 days post-challenge (dpc), and some chickens showed severe signs of listlessness, huddling, and ruffled feathers, with the mortality rate reaching 50% during the observation period.
T198 28380-28517 Sentence denotes At necropsy, the dead animals displayed typical kidney lesions characterized by swelling and urate deposition in the tubules and ureters.
T199 28518-28779 Sentence denotes In contrast to chickens vaccinated with rH120-S1/YZ, the chickens in the unvaccinated control group exhibited clinical signs at 3 dpc, and a 60% mortality rate; the gross lesions of the dead birds in this group were similar to that of the rH120 group (Fig. 7B).
T200 28780-28965 Sentence denotes Fig. 7 Efficacy of the rH120 and rH120-S1/YZ vaccines. (A) Percent survival of the vaccinated chickens challenged with the QX-like IBV rIBYZ strain during the 14-day observation period.
T201 28966-29221 Sentence denotes No mortality was observed in the chickens vaccinated with the rH120-S1/YZ strain. (B) Gross lesions observed on the kidneys of the vaccinated chickens challenged with the rIBYZ strain at 5 or 7 dpc. (C) The mean antibody OD value at 7, 14, 21, and 28 dpv.
T202 29222-29292 Sentence denotes All data are presented as the mean ± standard error of the mean (SEM).
T203 29294-29318 Sentence denotes 3.3.2 Antibody response
T204 29319-29386 Sentence denotes Antibodies against the IBVs were measured using an ELISA (Fig. 7C).
T205 29387-29634 Sentence denotes None of the birds in the rH120 or rH120-S1/YZ groups showed a positive antibody response at 7 dpv, whereas 100% of the birds had an antibody response detectable at 14 dpv, with the antibody level gradually increasing during the observation period.
T206 29635-29783 Sentence denotes However, there was no significant difference in the level of serum antibodies between rH120-vaccinated chickens and rH120-S1/YZ-vaccinated chickens.
T207 29784-29864 Sentence denotes No positive serum antibody response was detected in the non-vaccinated controls.
T208 29866-29879 Sentence denotes 4 Discussion
T209 29880-30125 Sentence denotes Vaccines, particularly live-attenuated vaccines, remain the most effective means of protection against IBV challenge (e.g., the Mass serotype strains H120, H52, Ma5, and W93, which are still widely used in the poultry industry) [38], [39], [40].
T210 30126-30344 Sentence denotes However, due to the poor cross-protection provided between the different serotypes, these attenuated serotype-specific vaccines cannot provide complete protection, and the IB endemic in China cannot be controlled [22].
T211 30345-30505 Sentence denotes Genetic mutations and immune pressure during the replication process of the single stranded RNA virus often results in the emergence of IBV variants [41], [42].
T212 30506-30683 Sentence denotes To date, at least six genotypes of IBV strains have been identified in China, of which the QX-type (first isolated in 1999) remains the most prevalent genotype [10], [42], [43].
T213 30684-30952 Sentence denotes The poor relationship between the QX-type strains, which are abundant and display variable virulence in various parts of China, and the Mass-type vaccine strains could explain the failure of the Mass-type vaccination programs to control IBV in these flocks [19], [39].
T214 30953-31095 Sentence denotes Consequently, the development of novel vaccines against circulating IBV strains in China using local IBV strains is required [20], [43], [44].
T215 31096-31256 Sentence denotes Optimal vaccination against circulating IBV strains in China requires the development of attenuated vaccines designed from local strains [20], [21], [22], [45].
T216 31257-31600 Sentence denotes However, due to the particularity of RNA virus replication, attenuated vaccine strains generated by continuous passage remain associated with the risk of reversion to virulence or potential recombination between vaccine strains and virulent field strains [27], [46], [47], which represents a substantial hidden concern to the poultry industry.
T217 31601-31882 Sentence denotes To reduce the problems associated with vaccine reversion, researchers have explored the option of creating vaccine viruses using reverse genetic technology (e.g., Beaudette strains carrying the S1 gene of the H120 vaccine strain, virulent M41 strain, or QX-like strain) [30], [48].
T218 31883-32067 Sentence denotes However, the titer of the Beaudette strains carrying the S1 gene of the vaccine H120 strain only reaches 106.13 ± 0.23 EID50 [49], which is lower than that of the H120 backbone strain.
T219 32068-32309 Sentence denotes Therefore, we aimed to develop a recombinant rH120-S1/YZ strain based on the H120 vaccine strain that carries the S1 gene of the ck/CH/IBYZ/2011 strain (a Chinese QX-like nephoropathogenic strain) using reverse genetic technology [35], [36].
T220 32310-32386 Sentence denotes In the present study, we isolated a nephoropathogenic strain (IBYZ) in 2011.
T221 32387-32524 Sentence denotes This strain was isolated, identified, and preserved from a large-scale chicken farm where an outbreak of IBV emerged in Jiangsu province.
T222 32525-32628 Sentence denotes Chickens infected with the IBYZ strain showed severe kidney damage and a high mortality rate (Fig. 3B).
T223 32629-32733 Sentence denotes The complete sequence has been deposited in the GenBank database under the accession number of KF663561.
T224 32734-32952 Sentence denotes The S1 gene sequencing data indicated that the IBYZ strain belonged to the QX-like genotype (Fig. 8 ), with a nucleotide homology with the attenuated vaccine H120 strain of only 77.4%, and amino acid homology of 77.1%.
T225 32953-33062 Sentence denotes Moreover, the S1/S2 cleavage site of IBYZ is HRRRR/S, which differed from RRFRR/S of the H120 vaccine strain.
T226 33063-33181 Sentence denotes After whole-genome sequencing, we constructed a molecular clone strain using reverse genetic technology, termed rIBYZ.
T227 33182-33354 Sentence denotes In addition, another strain used in this study is the live attenuated IBV vaccine, H120, and the molecular clone strain, rH120, which was constructed using the same method.
T228 33355-33526 Sentence denotes Fig. 8 Phylogenetic tree constructed based on the S1 gene of isolate ck/CH/IBYZ/2011 and 28 published IBV reference strains using the neighbor-joining method (Mega10.1.6).
T229 33527-33659 Sentence denotes The spike protein is the coronavirus structural proteins, which plays an important role on pathogenicity in coronaviruses [6], [50].
T230 33660-33771 Sentence denotes However, replacing the S gene of Beaudette strain by the virulent strains does not make it virulent [51], [52].
T231 33772-33932 Sentence denotes The S protein can be cleaved into S1 and S2 subunits at the S1/S2 cleavage site [53], the S1 subunit is responsible for receptor binding to the host cells [54].
T232 33933-34008 Sentence denotes Whether the S1 gene has an effect on the virulence of the virus is unknown.
T233 34009-34228 Sentence denotes In this study, the recombinant strain, rH120-S1/YZ, expressed the S1 gene of the QX-like strain, which retains the S1/S2 cleavage site of H120, maintained the ability to replicate and exhibited pathogenicity in embryos.
T234 34229-34322 Sentence denotes However, providing IBYZ S1 sequences to H120 did not increase its virulence to that of rIBYZ.
T235 34323-34452 Sentence denotes IBVs replicate in many epithelial cells, including respiratory tissues, the alimentary canal, kidney, gonads, and bursa [2], [6].
T236 34453-34582 Sentence denotes The QX-like rIBYZ strain is capable of considerable growth in the trachea, lung, and kidney, which leads to severe tissue damage.
T237 34583-34803 Sentence denotes In addition, this strain caused cilia necrosis and loss, lung congestion and hemorrhage, nephritis, as well as inflammatory cell infiltration in these tissues in infected chickens at different time points post-infection.
T238 34804-35077 Sentence denotes The ability of IBV to replicate within many respiratory, enteric, and other epithelial surfaces may be partially related to the fact that the attachment of IBV to host cells is dependent on sialic acid on the cell surface being recognized by the S1 subunit [6], [54], [55].
T239 35078-35213 Sentence denotes However, the binding of virus to the host cell is the first step in determining tropism and S2 is responsible for membrane fusion [56].
T240 35214-35395 Sentence denotes Thus, to further explore the different tissue tropism between rH120-S1/YZ and rIBYZ, we examined the viral loads and histopathology in the tissues of the rH120-S1/YZ-infected group.
T241 35396-35669 Sentence denotes It was found that rH120-S1/YZ remains moderately pathogenic in the trachea (e.g., some cilia necrosis and loss and decreased secretory cells) but no lesions were observed in the lungs and kidneys of infected chickens, in contrast to chickens infected with the rIBYZ strain.
T242 35670-35808 Sentence denotes This finding suggests that both the S2 and S1 genes might play an important role in viral tissue tropism as also suggested by others [57].
T243 35809-36004 Sentence denotes Another possibility is that the lack of viral replication and damage in kidney following rH120-S1/YZ is due to lower replication ability of backbone except S2 gene from its parental rH120 strain.
T244 36005-36353 Sentence denotes The viral load of the respiratory-type strain, rH120 in the different tissues indicated that the viral levels in the trachea, early following infection were significantly higher than those of rIBYZ, which indicates that the ability of the virus to attached to trachea epithelial cells of the rH120 strain was stronger than that of the rIBYZ strain.
T245 36354-36725 Sentence denotes However, during the later time points post-infection, the level of the rH120 strain was significantly lower than rIBYZ, which suggests that the virulence of IBV depends both on tissue invasion and viral replication ability, as well as other functions mediated by other viral proteins (e.g., non-structural, structural, and accessory proteins) [6], [29], [58], [59], [60].
T246 36726-36886 Sentence denotes The reduction of the viral load at 5 dpi in the group infected with the rIBYZ strain may be associated with the necrosis and shedding of the trachea epithelium.
T247 36887-37356 Sentence denotes Moreover, the ability to replication in the different organs of chickens infected with rH120-S1/YZ as reflected by viral loads at multiple time points was lower than that exhibited in the chickens infected with the rIBYZ strain, which demonstrated that the S1 subunit was not the only determinant of viral tropism that was consistent with results by others [57], [61], [62], and the significant difference in viral load was related to differences in the viral backbone.
T248 37357-37794 Sentence denotes However, when comparing the rH120-S1/YZ and rH120 strains which carry the same backbone, it was found that the viral RNA of rH120-S1/YZ in the lungs and kidneys was significantly lower than that of rH120, which may due to the replacement of the IBYZ S1 gene in the recombinant virus, whose structure on the surface contains some degree of changes, which we speculated that may affects the functionality of the S protein of coronaviruses.
T249 37795-37951 Sentence denotes Although cryo-EM structure of IBV spike protein has been determined, the relation between structure and function of different IBV S1 genes is unknown. [63].
T250 37952-38208 Sentence denotes In addition to the growth in epithelial tissues observed during the early infection period, IBV can establish long-term persistent infections in chicken flocks via oral and cloacal shedding, which represents a substantial challenge to IBV control [1], [6].
T251 38209-38354 Sentence denotes In this study, we detected viral RNA in the oral and cloacal swabs isolated from infected chickens at 7, 14, 18, 22, and 26 dpi by real-time PCR.
T252 38355-38530 Sentence denotes Compared with rH120 and rIBYZ, the viral load in both the oral and cloacal swabs of the rH120-S1/YZ group at different time points after infection was significantly decreased.
T253 38531-38732 Sentence denotes However, while it has been reported that the persistent virus will be re-excreted at the point of lay [1], the persistence of rH120-S1/YZ strain in the egg-laying chickens needs to be further verified.
T254 38733-38958 Sentence denotes In a word, due to its low virulence i presented in virus loading and lesion in different tissue, oral and cloacal shedding of host animals, rH120-S1/YZ can be considered a safe attenuated vaccine candidate for young chickens.
T255 38959-39211 Sentence denotes In addition to its role in tissue tropism, the S1 glycoprotein also has an important function in inducing a neutralizing antibody response [64], [65], and small differences in the S1 contribute to poor cross protectionby neutralization test [64], [66].
T256 39212-39422 Sentence denotes To evaluate the protective efficacy of this candidate vaccine, we selected the QX-like virulent rIBYZ strain to infect chickens at 14 dpv that were vaccinated with either the rH120-S1/YZ strain or rH120 strain.
T257 39423-39611 Sentence denotes We found that little protection against rIBYZ virulent strain challenge in the rH120 vaccinated group was induced, with a 50% survival rate and severe clinical symptoms associated with IB.
T258 39612-39703 Sentence denotes This finding could be explained by differences in the antigenicity between rH120 and rIBYZ.
T259 39704-39897 Sentence denotes No death, clinical signs, or lesions were observed in the rH120-S1/YZ-vaccinated group, indicating that this strain could provide effective protection against rIBYZ challenge in young chickens.
T260 39898-40148 Sentence denotes Since high humoral antibody titers can contribute to reduced viral replication in various organs and disease recovery [67], [68], the level of specific IgG antibodies remains an important standard for evaluating the immune response to an IBV vaccine.
T261 40149-40321 Sentence denotes In the present study, the humoral antibody level of chickens vaccinated with the rH120-S1/YZ strain was observed to gradually increase compared to the non-vaccinated group.
T262 40322-40662 Sentence denotes However, although the rH120 strain was able to induce similar levels of humoral antibodies, it provided poor protection against rIBYZ, suggesting that protection against IBV infection is not only with humoral immunity, but also with both mucosal immunity combined with the local tracheal and cellular immune response [69], [70], [71], [72].
T263 40663-40779 Sentence denotes Thus, the detection of mucosal and cellular immunity in rH120-S1/YZ-vaccinated animals requires further exploration.
T264 40780-41033 Sentence denotes Nevertheless, some studies have shown that a peptide located near the amino terminal end of S2 can be recognized by neutralizing monoclonal antibodies [73], and the S2 domain also plays an important role in inducing protective immunity [28], [61], [74].
T265 41034-41330 Sentence denotes Because the S2 domain plays an important role in cell tropism [57], we also considered that expressing the S1 subunit would provide greater safety than the entire S gene, which could lead to further destruction in some organs of the vaccinated chickens; however, further experiments are required.
T266 41332-41345 Sentence denotes 5 Conclusion
T267 41346-41618 Sentence denotes In conclusion, we constructed the recombinant strain, rH120-S1/YZ, which was based on the backbone of the H120 vaccine strain, and replaced the S1 gene with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011, isolated from China using the reverse genetic system.
T268 41619-41824 Sentence denotes The safety results showed that this recombinant strain was not lethal to one-day-old chicks and it had not gained the ability to tissue invasion or replication in the kidneys and lungs of infected animals.
T269 41825-41936 Sentence denotes Moreover, the viral load of the chickens was significantly decreased compared with the rH120 and rIBYZ strains.
T270 41937-42081 Sentence denotes Furthermore, rH120-S1/YZ was found to provide effective protection against challenge with the QX-like nephropathogenic strain in young chickens.
T271 42082-42207 Sentence denotes The level of antibody production in the serum of the vaccinated chickens detected by ELISA continued to increase after 7 dpi.
T272 42208-42349 Sentence denotes Thus, rH120-S1/YZ may be considered a potential live vaccine candidate for protection against Chinese QX-like nephropathogenic IBV infection.
T273 42351-42370 Sentence denotes 6 Ethics statement
T274 42371-42658 Sentence denotes All of the animals were cared for in accordance with the animal ethics guidelines and approved protocols, and the experimental protocols were performed with the approval of the Animal Welfare and Ethical Censor Committee of the Poultry Institute, Chinese Academy of Agriculture Sciences.
T275 42660-42700 Sentence denotes CRediT authorship contribution statement
T276 42701-42710 Sentence denotes Yi Jiang:
T277 42711-42895 Sentence denotes Conceptualization, Methodology, Software, Investigation, Validation, Visualization, Resources, Writing - original draft, Writing - review & editing, Visualization, Funding acquisition.
T278 42896-42905 Sentence denotes Xu Cheng:
T279 42906-42935 Sentence denotes Investigation, Data curation.
T280 42936-42948 Sentence denotes Xiumei Zhao:
T281 42949-42978 Sentence denotes Visualization, Investigation.
T282 42979-42986 Sentence denotes Yan Yu:
T283 42987-43011 Sentence denotes Investigation, Software.
T284 43012-43024 Sentence denotes Mingyan Gao:
T285 43025-43039 Sentence denotes Investigation.
T286 43040-43051 Sentence denotes Sheng Zhou:
T287 43052-43205 Sentence denotes Conceptualization, Validation, Resources, Writing - original draft, Writing - review & editing, Supervision, Project administration, Funding acquisition.
T288 43207-43240 Sentence denotes Declaration of Competing Interest
T289 43241-43411 Sentence denotes The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
T290 43413-43447 Sentence denotes Appendix A Supplementary material
T291 43448-43525 Sentence denotes The following are the Supplementary data to this article:Supplementary data 1
T292 43527-43542 Sentence denotes Acknowledgments
T293 43543-43700 Sentence denotes We would like to thank all members of the Poultry Institute, Chinese Academy of Agricultural Sciences (Yangzhou, China) for their contribution to this study.
T294 43702-43709 Sentence denotes Funding
T295 43710-43977 Sentence denotes This work was supported by the National Natural Science Foundations of China (31602091, 31101832, 31572524), the National Key Research and Development Program, China (2017YFD0500703), and Jiangsu Province Agricultural Science & Technology Support Program (BE2012369).
T296 43979-44006 Sentence denotes Contributors and authorship
T297 44007-44136 Sentence denotes Yi Jiang designed the study and conducted all the experiments, analysis and interpretation of the data, and wrote the manuscript.
T298 44137-44196 Sentence denotes Sheng Zhou helped perform the recombinant IBV construction.
T299 44197-44308 Sentence denotes Xu Cheng, Xiumei Zhao, Yan Yu, and Mingyan Gao participated in the whole animal experiment in different groups.
T300 44309-44369 Sentence denotes Xu Cheng conducted the experiments involving viral shedding.
T301 44370-44421 Sentence denotes All authors read and approved the final manuscript.
T302 44422-44538 Sentence denotes Appendix A Supplementary data to this article can be found online at https://doi.org/10.1016/j.vaccine.2020.01.001.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 23-33 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T2 619-629 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T3 2209-2219 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T4 2546-2556 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T5 2558-2566 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T6 2734-2743 Phenotype denotes nephritis http://purl.obolibrary.org/obo/HP_0000123
T7 2852-2862 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T8 4238-4247 Phenotype denotes nephritis http://purl.obolibrary.org/obo/HP_0000123
T9 14394-14402 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T10 14427-14432 Phenotype denotes rales http://purl.obolibrary.org/obo/HP_0030830
T11 14788-14796 Phenotype denotes eye drop http://purl.obolibrary.org/obo/HP_0000508
T12 16532-16540 Phenotype denotes eye drop http://purl.obolibrary.org/obo/HP_0000508
T13 17383-17391 Phenotype denotes eye drop http://purl.obolibrary.org/obo/HP_0000508
T14 21674-21682 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T15 21720-21725 Phenotype denotes rales http://purl.obolibrary.org/obo/HP_0030830
T16 22024-22029 Phenotype denotes Edema http://purl.obolibrary.org/obo/HP_0000969
T17 22259-22267 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T18 28163-28171 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T19 28176-28191 Phenotype denotes nasal discharge http://purl.obolibrary.org/obo/HP_0031417
T20 32578-32591 Phenotype denotes kidney damage http://purl.obolibrary.org/obo/HP_0000112
T21 34672-34681 Phenotype denotes nephritis http://purl.obolibrary.org/obo/HP_0000123

2_test

Id Subject Object Predicate Lexical cue
32057575-22702451-143294022 2436-2437 22702451 denotes 1
32057575-16537157-143294023 2441-2442 16537157 denotes 2
32057575-23397833-143294024 2446-2447 23397833 denotes 3
32057575-22702451-143294025 2621-2622 22702451 denotes 1
32057575-16537157-143294026 2803-2804 16537157 denotes 2
32057575-23397833-143294027 2808-2809 23397833 denotes 3
32057575-14676007-143294028 3029-3030 14676007 denotes 4
32057575-12885925-143294029 3468-3469 12885925 denotes 5
32057575-17296157-143294030 3473-3474 17296157 denotes 6
32057575-1708184-143294031 3713-3714 1708184 denotes 8
32057575-25954763-143294032 3878-3879 25954763 denotes 9
32057575-15223561-143294033 4208-4210 15223561 denotes 10
32057575-22545524-143294034 4214-4216 22545524 denotes 11
32057575-25000989-143294035 4220-4222 25000989 denotes 12
32057575-20556502-143294036 4226-4228 20556502 denotes 13
32057575-6246669-143294037 4709-4711 6246669 denotes 15
32057575-5388980-143294038 4715-4717 5388980 denotes 16
32057575-1659365-143294039 4773-4775 1659365 denotes 17
32057575-22702451-143294040 4923-4924 22702451 denotes 1
32057575-19590226-143294041 5276-5278 19590226 denotes 18
32057575-25168045-143294042 5282-5284 25168045 denotes 19
32057575-26277655-143294043 5623-5625 26277655 denotes 20
32057575-29496346-143294044 5629-5631 29496346 denotes 21
32057575-29859801-143294045 5635-5637 29859801 denotes 22
32057575-29891352-143294046 5641-5643 29891352 denotes 23
32057575-21331953-143294047 5647-5649 21331953 denotes 24
32057575-16860445-143294048 5760-5762 16860445 denotes 25
32057575-8719209-143294049 5766-5768 8719209 denotes 26
32057575-25954763-143294050 5920-5921 25954763 denotes 9
32057575-22798607-143294051 6057-6059 22798607 denotes 27
32057575-29366709-143294052 6513-6515 29366709 denotes 29
32057575-30355423-143294053 6519-6521 30355423 denotes 30
32057575-11711626-143294054 6608-6610 11711626 denotes 31
32057575-22999521-143294055 6614-6616 22999521 denotes 32
32057575-23840781-143294056 6620-6622 23840781 denotes 33
32057575-7980002-143294057 6995-6997 7980002 denotes 34
32057575-12885925-143294058 7229-7230 12885925 denotes 5
32057575-30355423-143294059 7240-7242 30355423 denotes 30
32057575-18484262-143294060 30109-30111 18484262 denotes 38
32057575-16990149-143294061 30115-30117 16990149 denotes 39
32057575-16191702-143294062 30121-30123 16191702 denotes 40
32057575-29859801-143294063 30340-30342 29859801 denotes 22
32057575-26482289-143294064 30495-30497 26482289 denotes 41
32057575-27530216-143294065 30501-30503 27530216 denotes 42
32057575-15223561-143294066 30667-30669 15223561 denotes 10
32057575-27530216-143294067 30673-30675 27530216 denotes 42
32057575-20833270-143294068 30679-30681 20833270 denotes 43
32057575-25168045-143294069 30942-30944 25168045 denotes 19
32057575-16990149-143294070 30948-30950 16990149 denotes 39
32057575-26277655-143294071 31079-31081 26277655 denotes 20
32057575-20833270-143294072 31085-31087 20833270 denotes 43
32057575-16405010-143294073 31091-31093 16405010 denotes 44
32057575-26277655-143294074 31234-31236 26277655 denotes 20
32057575-29496346-143294075 31240-31242 29496346 denotes 21
32057575-29859801-143294076 31246-31248 29859801 denotes 22
32057575-25636916-143294077 31252-31254 25636916 denotes 45
32057575-22798607-143294078 31513-31515 22798607 denotes 27
32057575-18262691-143294079 31519-31521 18262691 denotes 46
32057575-20153350-143294080 31525-31527 20153350 denotes 47
32057575-30355423-143294081 31872-31874 30355423 denotes 30
32057575-15609511-143294082 31878-31880 15609511 denotes 48
32057575-17296157-143294083 33650-33651 17296157 denotes 6
32057575-3010596-143294084 33655-33657 3010596 denotes 50
32057575-22179147-143294085 33761-33763 22179147 denotes 51
32057575-15564488-143294086 33767-33769 15564488 denotes 52
32057575-3010595-143294087 33853-33855 3010595 denotes 53
32057575-23896748-143294088 33928-33930 23896748 denotes 54
32057575-16537157-143294089 34444-34445 16537157 denotes 2
32057575-17296157-143294090 34449-34450 17296157 denotes 6
32057575-17296157-143294091 35062-35063 17296157 denotes 6
32057575-23896748-143294092 35067-35069 23896748 denotes 54
32057575-25451062-143294093 35073-35075 25451062 denotes 55
32057575-21697468-143294094 35209-35211 21697468 denotes 56
32057575-24041648-143294095 35804-35806 24041648 denotes 57
32057575-17296157-143294096 36698-36699 17296157 denotes 6
32057575-29366709-143294097 36703-36705 29366709 denotes 29
32057575-21047962-143294098 36715-36717 21047962 denotes 59
32057575-19816578-143294099 36721-36723 19816578 denotes 60
32057575-24041648-143294100 37245-37247 24041648 denotes 57
32057575-28899630-143294101 37251-37253 28899630 denotes 61
32057575-29684409-143294102 37257-37259 29684409 denotes 62
32057575-29684066-143294103 37947-37949 29684066 denotes 63
32057575-22702451-143294104 38200-38201 22702451 denotes 1
32057575-17296157-143294105 38205-38206 17296157 denotes 6
32057575-22702451-143294106 38634-38635 22702451 denotes 1
32057575-2462314-143294107 39099-39101 2462314 denotes 64
32057575-9672590-143294108 39105-39107 9672590 denotes 65
32057575-2462314-143294109 39201-39203 2462314 denotes 64
32057575-1372036-143294110 39207-39209 1372036 denotes 66
32057575-206936-143294111 40017-40019 206936 denotes 67
32057575-9356695-143294112 40023-40025 9356695 denotes 68
32057575-9188584-143294113 40640-40642 9188584 denotes 69
32057575-9008335-143294114 40646-40648 9008335 denotes 70
32057575-10823726-143294115 40652-40654 10823726 denotes 71
32057575-10717287-143294116 40658-40660 10717287 denotes 72
32057575-2477454-143294117 40932-40934 2477454 denotes 73
32057575-28899630-143294118 41023-41025 28899630 denotes 61
32057575-15868095-143294119 41029-41031 15868095 denotes 74
32057575-24041648-143294120 41097-41099 24041648 denotes 57

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 12-22 Species denotes infectious Tax:10995
4 23-45 Disease denotes bronchitis coronavirus MESH:D001991
5 89-105 Disease denotes nephropathogenic
7 225-228 Species denotes IBV Tax:11120
10 283-288 Chemical denotes rH120
11 404-420 Disease denotes nephropathogenic
25 1122-1129 Species denotes chicken Tax:9031
26 1448-1456 Species denotes chickens Tax:9031
27 1866-1874 Species denotes chickens Tax:9031
28 647-657 Species denotes infectious Tax:10995
29 1752-1762 Species denotes IBV strain Tax:11120
30 1924-1927 Species denotes IBV Tax:11120
31 1294-1299 Chemical denotes rH120
32 608-629 Disease denotes Infectious bronchitis MESH:D001991
33 658-671 Disease denotes viral disease MESH:D001102
34 1040-1056 Disease denotes nephropathogenic
35 1300-1308 Disease denotes infected MESH:D007239
36 1338-1352 Disease denotes rIBYZ-infected MESH:D007239
37 1363-1372 Disease denotes mortality MESH:D003643
44 2198-2219 Disease denotes Infectious bronchitis MESH:D001991
45 2250-2269 Disease denotes respiratory disease MESH:D012140
46 2339-2352 Disease denotes viral disease MESH:D001102
47 2546-2556 Disease denotes depression MESH:D000275
48 2558-2566 Disease denotes coughing MESH:D003371
49 2734-2743 Disease denotes nephritis MESH:D009393
54 2841-2868 Species denotes infectious bronchitis virus Tax:11120
55 2988-3001 Species denotes Coronaviridae Tax:11118
56 2870-2873 Species denotes IBV Tax:11120
57 3063-3066 Species denotes IBV Tax:11120
67 4306-4314 Species denotes chickens Tax:9031
68 3528-3531 Species denotes IBV Tax:11120
69 3643-3646 Species denotes IBV Tax:11120
70 3694-3697 Species denotes IBV Tax:11120
71 3892-3895 Species denotes IBV Tax:11120
72 3617-3627 Disease denotes infections MESH:D007239
73 4238-4247 Disease denotes nephritis MESH:D009393
74 4280-4289 Disease denotes mortality MESH:D003643
75 4315-4323 Disease denotes infected MESH:D007239
84 5226-5234 Species denotes chickens Tax:9031
85 5481-5488 Species denotes chicken Tax:9031
86 4976-4979 Species denotes IBV Tax:11120
87 5380-5383 Species denotes IBV Tax:11120
88 5610-5613 Species denotes IBV Tax:11120
89 4553-4569 Disease denotes viral infections MESH:D001102
90 5213-5222 Disease denotes infection MESH:D007239
91 5711-5731 Disease denotes bacterial infections MESH:D001424
99 7632-7640 Species denotes chickens Tax:9031
100 6381-6384 Species denotes IBV Tax:11120
101 6411-6414 Species denotes IBV Tax:11120
102 6919-6922 Species denotes IBV Tax:11120
103 7055-7058 Species denotes IBV Tax:11120
104 7657-7660 Species denotes IBV Tax:11120
105 7457-7473 Disease denotes nephropathogenic
108 7973-7976 Species denotes IBV Tax:11120
109 7901-7905 Chemical denotes IBYZ
117 8270-8277 Species denotes chicken Tax:9031
118 8413-8420 Species denotes Chicken Tax:9031
119 8573-8581 Species denotes chickens Tax:9031
120 8595-8602 Species denotes chicken Tax:9031
121 8697-8705 Species denotes chickens Tax:9031
122 8773-8778 Chemical denotes water MESH:D014867
123 8421-8439 Disease denotes Infectious Disease MESH:D003141
126 9525-9529 Chemical denotes IBYZ
127 9550-9561 Chemical denotes pYZS1H120S2
130 9193-9200 Species denotes chicken Tax:9031
131 9045-9051 CellLine denotes BHK-21 CVCL:1914
133 10600-10607 Species denotes Chicken Tax:9031
139 10675-10682 Species denotes chicken Tax:9031
140 10851-10858 Species denotes chicken Tax:9031
141 10879-10884 Species denotes Chick Tax:9031
142 10702-10707 Chemical denotes rH120
143 10709-10714 Chemical denotes rIBYZ
145 10987-10994 Species denotes chicken Tax:9031
148 11042-11049 Species denotes chicken Tax:9031
149 11196-11199 Species denotes IBV Tax:11120
152 11762-11769 Species denotes chicken Tax:9031
153 12136-12142 Chemical denotes TRIzol MESH:C411644
160 13037-13044 Species denotes chicken Tax:9031
161 13445-13455 Species denotes infectious Tax:10995
162 13551-13561 Species denotes infectious Tax:10995
163 13441-13444 Species denotes IBV Tax:11120
164 13167-13170 Chemical denotes PBS MESH:D007854
165 13273-13279 Disease denotes deaths MESH:D003643
178 13729-13737 Species denotes chickens Tax:9031
179 13878-13886 Species denotes chickens Tax:9031
180 13950-13958 Species denotes chickens Tax:9031
181 14047-14052 Species denotes chick Tax:9031
182 14439-14447 Species denotes chickens Tax:9031
183 13816-13821 Chemical denotes water MESH:D014867
184 14181-14184 Chemical denotes PBS MESH:D007854
185 14223-14232 Disease denotes mortality MESH:D003643
186 14337-14349 Disease denotes IB infection MESH:D007239
187 14367-14376 Disease denotes infection MESH:D007239
188 14394-14402 Disease denotes coughing MESH:D003371
189 14492-14506 Disease denotes kidney lesions MESH:D007674
191 14540-14555 Disease denotes viral infection MESH:D001102
197 14593-14601 Species denotes chickens Tax:9031
198 14841-14846 Species denotes chick Tax:9031
199 14833-14836 Chemical denotes PBS MESH:D007854
200 15063-15066 Chemical denotes PBS MESH:D007854
201 15162-15168 Chemical denotes TRIzol MESH:C411644
212 15653-15661 Species denotes chickens Tax:9031
213 15889-15897 Species denotes chickens Tax:9031
214 15606-15611 Chemical denotes rIBYZ
215 15956-15959 Chemical denotes PBS MESH:D007854
216 16058-16066 Chemical denotes formalin MESH:D005557
217 16080-16088 Chemical denotes paraffin MESH:D010232
218 16131-16142 Chemical denotes hematoxylin MESH:D006416
219 16147-16152 Chemical denotes eosin MESH:D004801
220 15644-15652 Disease denotes infected MESH:D007239
221 15715-15723 Disease denotes bleeding MESH:D006470
225 16484-16489 Species denotes chick Tax:9031
226 16476-16479 Chemical denotes PBS MESH:D007854
227 16632-16635 Chemical denotes PBS MESH:D007854
235 17048-17056 Species denotes chickens Tax:9031
236 17094-17102 Species denotes chickens Tax:9031
237 17288-17296 Species denotes chickens Tax:9031
238 17527-17535 Species denotes chickens Tax:9031
239 17251-17254 Chemical denotes PBS MESH:D007854
240 17481-17490 Disease denotes mortality MESH:D003643
241 17585-17599 Disease denotes kidney lesions MESH:D007674
252 17701-17709 Species denotes chickens Tax:9031
253 18206-18213 Species denotes chicken Tax:9031
254 18440-18447 Species denotes rabbits Tax:9986
255 18098-18101 Species denotes IBV Tax:11120
256 18331-18334 Species denotes IBV Tax:11120
257 18371-18378 Species denotes chicken Tax:9031
258 18178-18182 Chemical denotes IBYZ
259 18495-18525 Chemical denotes 3,3′,5,5′-Tetramethylbenzidine MESH:C021758
260 18526-18529 Chemical denotes TMB
261 18580-18585 Chemical denotes H2SO4
272 19782-19789 Species denotes chicken Tax:9031
273 19849-19854 Species denotes chick Tax:9031
274 19896-19903 Species denotes chicken Tax:9031
275 19994-19999 Species denotes Chick Tax:9031
276 20137-20144 Species denotes chicken Tax:9031
277 20260-20267 Species denotes chicken Tax:9031
278 20517-20522 Chemical denotes rH120
279 20533-20538 Chemical denotes rH120
280 20542-20544 Chemical denotes YZ
281 19840-19848 Disease denotes infected MESH:D007239
284 19340-19345 Species denotes chick Tax:9031
285 19463-19468 Disease denotes death MESH:D003643
287 21076-21085 Disease denotes infection MESH:D007239
292 22878-22886 Species denotes chickens Tax:9031
293 22671-22692 Disease denotes SPF chickens infected MESH:D002644
294 22750-22759 Disease denotes mortality MESH:D003643
295 22854-22877 Disease denotes kidneys of the infected MESH:D007239
320 21451-21459 Species denotes chickens Tax:9031
321 21547-21555 Species denotes chickens Tax:9031
322 21617-21625 Species denotes chickens Tax:9031
323 22196-22204 Species denotes chickens Tax:9031
324 22283-22291 Species denotes chickens Tax:9031
325 22313-22321 Species denotes chickens Tax:9031
326 22536-22539 Species denotes IBV Tax:11120
327 21385-21390 Chemical denotes rIBYZ
328 21563-21568 Chemical denotes rIBYZ
329 21992-21997 Chemical denotes urate MESH:D014527
330 22423-22428 Chemical denotes rH120
331 22442-22444 Chemical denotes YZ
332 21335-21340 Disease denotes death MESH:D003643
333 21471-21480 Disease denotes mortality MESH:D003643
334 21538-21546 Disease denotes infected MESH:D007239
335 21636-21656 Disease denotes respiratory symptoms MESH:D012818
336 21674-21682 Disease denotes coughing MESH:D003371
337 21926-21935 Disease denotes hyperemia MESH:D006940
338 21941-21951 Disease denotes hemorrhage MESH:D006470
339 21979-21987 Disease denotes swelling MESH:D004487
340 22024-22029 Disease denotes Edema MESH:D004487
341 22259-22267 Disease denotes coughing MESH:D003371
342 22304-22312 Disease denotes infected MESH:D007239
343 22514-22519 Disease denotes death MESH:D003643
348 24246-24267 Disease denotes SPF chickens infected MESH:D002644
349 24391-24404 Disease denotes necrosis loss MESH:D009336
350 24456-24466 Disease denotes hemorrhage MESH:D006470
351 24701-24713 Disease denotes inflammation MESH:D007249
367 22935-22943 Species denotes chickens Tax:9031
368 23475-23483 Species denotes chickens Tax:9031
369 23523-23531 Species denotes chickens Tax:9031
370 23915-23923 Species denotes chickens Tax:9031
371 24137-24145 Species denotes chickens Tax:9031
372 24066-24069 Species denotes IBV Tax:11120
373 23458-23463 Chemical denotes rIBYZ
374 23510-23515 Chemical denotes rH120
375 23040-23054 Disease denotes cilia necrosis MESH:C536287
376 23093-23103 Disease denotes hemorrhage MESH:D006470
377 23183-23197 Disease denotes rIBYZ-infected MESH:D007239
378 23217-23227 Disease denotes hemorrhage MESH:D006470
379 23618-23627 Disease denotes infection MESH:D007239
380 23906-23914 Disease denotes infected MESH:D007239
381 23935-23944 Disease denotes infection MESH:D007239
383 26090-26111 Disease denotes SPF chickens infected MESH:D002644
388 25752-25760 Species denotes chickens Tax:9031
389 25613-25616 Species denotes IBV Tax:11120
390 25394-25403 Disease denotes infection MESH:D007239
391 25727-25751 Disease denotes kidney of rIBYZ-infected MESH:D007239
394 27379-27387 Species denotes chickens Tax:9031
395 27388-27396 Disease denotes infected MESH:D007239
403 26714-26722 Species denotes chickens Tax:9031
404 26758-26766 Species denotes chickens Tax:9031
405 26475-26478 Species denotes IBV Tax:11120
406 27000-27005 Chemical denotes rIBYZ
407 26479-26488 Disease denotes infection MESH:D007239
408 26723-26731 Disease denotes infected MESH:D007239
409 26767-26775 Disease denotes infected MESH:D007239
411 27792-27795 Species denotes IBV Tax:11120
419 28874-28882 Species denotes chickens Tax:9031
420 28999-29007 Species denotes chickens Tax:9031
421 29040-29051 Species denotes strain. (B) Tax:35794
422 29108-29116 Species denotes chickens Tax:9031
423 28911-28914 Species denotes IBV Tax:11120
424 29137-29142 Chemical denotes rIBYZ
425 28969-28978 Disease denotes mortality MESH:D003643
438 28082-28090 Species denotes chickens Tax:9031
439 28234-28242 Species denotes chickens Tax:9031
440 28533-28541 Species denotes chickens Tax:9031
441 28575-28583 Species denotes chickens Tax:9031
442 28034-28039 Chemical denotes rIBYZ
443 28473-28478 Chemical denotes urate MESH:D014527
444 27928-27937 Disease denotes mortality MESH:D003643
445 28163-28171 Disease denotes coughing MESH:D003371
446 28321-28330 Disease denotes mortality MESH:D003643
447 28428-28442 Disease denotes kidney lesions MESH:D007674
448 28460-28468 Disease denotes swelling MESH:D004487
449 28663-28672 Disease denotes mortality MESH:D003643
452 29738-29746 Species denotes chickens Tax:9031
453 29774-29782 Species denotes chickens Tax:9031
460 29983-29986 Species denotes IBV Tax:11120
461 30481-30484 Species denotes IBV Tax:11120
462 30541-30544 Species denotes IBV Tax:11120
463 30921-30924 Species denotes IBV Tax:11120
464 31021-31024 Species denotes IBV Tax:11120
465 31054-31057 Species denotes IBV Tax:11120
467 31136-31139 Species denotes IBV Tax:11120
469 33457-33460 Species denotes IBV Tax:11120
481 32458-32465 Species denotes chicken Tax:9031
482 32525-32533 Species denotes Chickens Tax:9031
483 32492-32495 Species denotes IBV Tax:11120
484 33252-33255 Species denotes IBV Tax:11120
485 32372-32376 Chemical denotes IBYZ
486 32552-32556 Chemical denotes IBYZ
487 32781-32785 Chemical denotes IBYZ
488 32990-32994 Chemical denotes IBYZ
489 32534-32542 Disease denotes infected MESH:D007239
490 32578-32591 Disease denotes kidney damage MESH:D007674
491 32603-32612 Disease denotes mortality MESH:D003643
532 33552-33563 Species denotes coronavirus Tax:11118
533 33635-33648 Species denotes coronaviruses Tax:11118
534 34754-34762 Species denotes chickens Tax:9031
535 35604-35612 Species denotes chickens Tax:9031
536 35629-35637 Species denotes chickens Tax:9031
537 36951-36959 Species denotes chickens Tax:9031
538 37075-37083 Species denotes chickens Tax:9031
539 37780-37793 Species denotes coronaviruses Tax:11118
540 38097-38104 Species denotes chicken Tax:9031
541 38299-38307 Species denotes chickens Tax:9031
542 38694-38702 Species denotes chickens Tax:9031
543 38949-38957 Species denotes chickens Tax:9031
544 34819-34822 Species denotes IBV Tax:11120
545 34960-34963 Species denotes IBV Tax:11120
546 36511-36514 Species denotes IBV Tax:11120
547 37825-37828 Species denotes IBV Tax:11120
548 37921-37924 Species denotes IBV Tax:11120
549 38044-38047 Species denotes IBV Tax:11120
550 38187-38190 Species denotes IBV Tax:11120
551 34994-35005 Chemical denotes sialic acid MESH:D019158
552 36798-36803 Chemical denotes rIBYZ
553 34615-34629 Disease denotes cilia necrosis MESH:C536287
554 34660-34670 Disease denotes hemorrhage MESH:D006470
555 34672-34681 Disease denotes nephritis MESH:D009393
556 34745-34753 Disease denotes infected MESH:D007239
557 34793-34802 Disease denotes infection MESH:D007239
558 35380-35388 Disease denotes infected MESH:D007239
559 35483-35497 Disease denotes cilia necrosis MESH:C536287
560 35584-35603 Disease denotes kidneys of infected MESH:D007239
561 35638-35646 Disease denotes infected MESH:D007239
562 36147-36156 Disease denotes infection MESH:D007239
563 36397-36406 Disease denotes infection MESH:D007239
564 36780-36788 Disease denotes infected MESH:D007239
565 36838-36846 Disease denotes necrosis MESH:D009336
566 36960-36968 Disease denotes infected MESH:D007239
567 37084-37092 Disease denotes infected MESH:D007239
568 38026-38035 Disease denotes infection MESH:D007239
569 38083-38093 Disease denotes infections MESH:D007239
570 38290-38298 Disease denotes infected MESH:D007239
571 38492-38501 Disease denotes infection MESH:D007239
585 39331-39339 Species denotes chickens Tax:9031
586 39888-39896 Species denotes chickens Tax:9031
587 40201-40209 Species denotes chickens Tax:9031
588 41278-41286 Species denotes chickens Tax:9031
589 40136-40139 Species denotes IBV Tax:11120
590 39308-39313 Chemical denotes rIBYZ
591 39463-39468 Chemical denotes rIBYZ
592 39502-39507 Chemical denotes rH120
593 39687-39692 Chemical denotes rH120
594 39697-39702 Chemical denotes rIBYZ
595 39863-39868 Chemical denotes rIBYZ
596 39707-39712 Disease denotes death MESH:D003643
597 40492-40505 Disease denotes IBV infection MESH:D007239
606 41857-41865 Species denotes chickens Tax:9031
607 42072-42080 Species denotes chickens Tax:9031
608 42146-42154 Species denotes chickens Tax:9031
609 41950-41955 Chemical denotes rH120
610 41523-41539 Disease denotes nephropathogenic
611 41807-41815 Disease denotes infected MESH:D007239
612 42039-42055 Disease denotes nephropathogenic
613 42318-42348 Disease denotes nephropathogenic IBV infection MESH:D007239