PMC:7114094 / 3091-4260 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7114094","sourcedb":"PMC","sourceid":"7114094","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7114094","text":"Characterization of an nCoV-peculiar sequence at the S1/S2 cleavage site in the S-protein sequence, compared SARS-like CoV. (A) Phylogenetic tree of selected coronaviruses from genera alphacoronavirus (α-Cov) and betacoronavirus (β-CoV), lineages a, b, c and d: 2019-nCoV (NC_045512.2), CoV-ZXC21 (MG772934), SARS-CoV (NC_004718.3), SARS-like BM4821 (MG772934), HCoV-OC43 (AY391777), HKU9-1 (EF065513), HCoV-NL63 (KF530114.1), HCoV229E (KF514433.1), MERS-CoV (NC019843.3), HKU1 (NC_006577.2). The phylogenetic tree was obtained on the Orf1ab amino acid sequence using the Maximum Likelihood method by Mega X software. Red asterisks indicate the presence of a canonical furin-like cleavage motif at site 1; (B) Alignment of the coding and amino acid sequences of the S-protein from CoV-ZXC21 and 2019-nCoV at the S1/S2 site. The 2019-nCoV-specific sequence is in bold. The sequence of CoV-ZXC21 S-protein at this position is representative of the sequence of the other betacoronaviruses belonging to lineage b, except the one of 2019-nCoV. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this 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