PMC:7113610 / 15739-17570
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 574 | 507-511 | Gene | denotes | DPP4 | Gene:1803 |
| 575 | 766-770 | Gene | denotes | ACE2 | Gene:59272 |
| 576 | 239-247 | Species | denotes | SARS-CoV | Tax:694009 |
| 577 | 348-356 | Species | denotes | SARS-CoV | Tax:694009 |
| 578 | 361-369 | Species | denotes | MERS-CoV | Tax:1335626 |
| 579 | 414-418 | Species | denotes | Mice | Tax:10090 |
| 580 | 454-470 | Species | denotes | MERS-coronavirus | Tax:1335626 |
| 581 | 555-577 | Species | denotes | 2019-novel coronavirus | Tax:2697049 |
| 582 | 619-624 | Species | denotes | human | Tax:9606 |
| 583 | 639-642 | Species | denotes | CoV | Tax:11118 |
| 584 | 678-686 | Species | denotes | SARS-CoV | Tax:694009 |
| 585 | 744-754 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 586 | 760-765 | Species | denotes | human | Tax:9606 |
| 587 | 816-835 | Species | denotes | Novel coronaviruses | Tax:2697049 |
| 588 | 983-1002 | Species | denotes | novel coronaviruses | Tax:2697049 |
| 589 | 1004-1012 | Species | denotes | SARS-CoV | Tax:694009 |
| 590 | 1072-1076 | Species | denotes | Rats | Tax:10116 |
| 591 | 1264-1283 | Species | denotes | novel coronaviruses | Tax:2697049 |
| 592 | 1295-1299 | Species | denotes | mice | Tax:10090 |
| 593 | 1383-1393 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 594 | 1542-1552 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 595 | 1579-1587 | Species | denotes | patients | Tax:9606 |
| 596 | 1820-1830 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 597 | 888-896 | Species | denotes | modified | Tax:467144 |
| 598 | 317-326 | Disease | denotes | infection | MESH:D007239 |
| 599 | 441-450 | Disease | denotes | infection | MESH:D007239 |
| 600 | 1402-1410 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 601 | 1559-1578 | Disease | denotes | SARS-CoV-2 infected | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T74 | 541-547 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T75 | 771-775 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T76 | 1142-1154 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T77 | 1220-1232 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T162 | 239-247 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T163 | 239-243 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T164 | 317-326 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T165 | 348-356 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T166 | 348-352 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T167 | 441-450 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T168 | 625-629 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T169 | 678-686 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T170 | 678-682 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T171 | 716-726 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T172 | 744-752 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T173 | 744-748 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T174 | 807-811 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T175 | 1004-1012 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T176 | 1004-1008 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 1383-1391 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 1383-1387 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 1402-1410 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T180 | 1542-1550 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T181 | 1542-1546 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 1559-1567 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T183 | 1559-1563 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T184 | 1820-1828 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T185 | 1820-1824 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T152 | 40-46 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | Animal |
| T153 | 59-60 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T154 | 257-263 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T155 | 405-412 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T156 | 619-624 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T157 | 635-638 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
| T158 | 660-666 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T159 | 760-765 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T160 | 771-775 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T161 | 897-905 | http://purl.obolibrary.org/obo/NCBITaxon_10026 | denotes | hamsters |
| T162 | 921-928 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T163 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T164 | 1122-1123 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T165 | 1156-1158 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T166 | 1412-1420 | http://purl.obolibrary.org/obo/CLO_0001013 | denotes | 46], [47 |
| T167 | 1412-1420 | http://purl.obolibrary.org/obo/CLO_0052464 | denotes | 46], [47 |
| T168 | 1426-1427 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T169 | 1554-1556 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T170 | 1732-1733 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T59 | 1142-1154 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T60 | 1220-1232 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T61 | 1529-1533 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 370-382 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T17 | 1804-1816 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T117 | 0-39 | Sentence | denotes | The major obstacle in research progress |
| T118 | 40-196 | Sentence | denotes | Animal models play a vital role to uncover the mechanisms of viral pathogenicity from the entrance to the transmission and designing therapeutic strategies. |
| T119 | 197-332 | Sentence | denotes | Previously, to examine the replication of SARS-CoV, various animal models were used which showed the symptoms of severe infection [43]. |
| T120 | 333-413 | Sentence | denotes | In contrast to SARS-CoV, no MERS-CoV pathogenesis was observed in small animals. |
| T121 | 414-526 | Sentence | denotes | Mice are not vulnerable to infection by MERS-coronavirus due to the non-compatibility of the DPP4 receptor [44]. |
| T122 | 527-755 | Sentence | denotes | As the entire genome of the 2019-novel coronavirus is more than 80% similar to the previous human SARS-like bat CoV, previously used animal models for SARS-CoV can be utilized to study the infectious pathogenicity of SARS-CoV-2. |
| T123 | 756-836 | Sentence | denotes | The human ACE2 cell receptor is recognized by both SARS and Novel coronaviruses. |
| T124 | 837-1003 | Sentence | denotes | Conclusively, TALEN or CRISPR-mediated genetically modified hamsters or other small animals can be utilized for the study of the pathogenicity of novel coronaviruses. |
| T125 | 1004-1160 | Sentence | denotes | SARS-CoV has been reported to replicate and cause severe disease in Rats (F344), where the sequence analysis revealed a mutation at spike glycoprotein [45]. |
| T126 | 1161-1284 | Sentence | denotes | Thus, it could be another suitable option to develop spike glycoprotein targeting therapeutics against novel coronaviruses. |
| T127 | 1285-1422 | Sentence | denotes | Recently, mice models and clinical isolates were used to develop any therapeutic strategy against SARS-CoV-2 induced COVID-19 [46], [47]. |
| T128 | 1423-1558 | Sentence | denotes | In a similar study, artificial intelligence prediction was used to investigate the inhibitory role of the drug against SARS-CoV-2 [48]. |
| T129 | 1559-1658 | Sentence | denotes | SARS-CoV-2 infected patients were also used to conduct randomized clinical trials [46], [49], [50]. |
| T130 | 1659-1831 | Sentence | denotes | It is now important that the scientists worldwide collaborate the design a suitable model and investigate the in vivo mechanisms associated with pathogenesis of SARS-CoV-2. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 310-326 | Phenotype | denotes | severe infection | http://purl.obolibrary.org/obo/HP_0032169 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T498 | 40-46 | NCBITaxon:33208 | denotes | Animal |
| T499 | 101-106 | NCBITaxon:10239 | denotes | viral |
| T500 | 107-120 | BV_19 | denotes | pathogenicity |
| T501 | 224-235 | GO:0006260 | denotes | replication |
| T502 | 239-247 | SP_10 | denotes | SARS-CoV |
| T503 | 257-263 | NCBITaxon:33208 | denotes | animal |
| T504 | 348-356 | SP_10 | denotes | SARS-CoV |
| T505 | 361-369 | SP_9 | denotes | MERS-CoV |
| T506 | 405-412 | NCBITaxon:33208 | denotes | animals |
| T507 | 414-418 | NCBITaxon:10088 | denotes | Mice |
| T508 | 454-458 | SP_9 | denotes | MERS |
| T509 | 459-470 | NCBITaxon:11118 | denotes | coronavirus |
| T510 | 507-511 | PG_7;PR:000001341 | denotes | DPP4 |
| T511 | 541-547 | SO:0001026 | denotes | genome |
| T512 | 566-577 | NCBITaxon:11118 | denotes | coronavirus |
| T513 | 619-624 | SP_6;NCBITaxon:9606 | denotes | human |
| T514 | 625-629 | SP_10 | denotes | SARS |
| T515 | 635-638 | SP_2 | denotes | bat |
| T516 | 660-666 | NCBITaxon:33208 | denotes | animal |
| T517 | 678-686 | SP_10 | denotes | SARS-CoV |
| T518 | 727-740 | BV_19 | denotes | pathogenicity |
| T519 | 744-754 | SP_7 | denotes | SARS-CoV-2 |
| T520 | 760-765 | SP_6;NCBITaxon:9606;PG_10 | denotes | human |
| T521 | 766-770 | PG_10;PR:000003622 | denotes | ACE2 |
| T522 | 807-811 | SP_10 | denotes | SARS |
| T523 | 822-835 | NCBITaxon:11118 | denotes | coronaviruses |
| T524 | 876-887 | SO:0000704 | denotes | genetically |
| T525 | 921-928 | NCBITaxon:33208 | denotes | animals |
| T526 | 966-979 | BV_19 | denotes | pathogenicity |
| T527 | 989-1002 | NCBITaxon:11118 | denotes | coronaviruses |
| T528 | 1004-1012 | SP_10 | denotes | SARS-CoV |
| T529 | 1072-1076 | NCBITaxon:10114 | denotes | Rats |
| T530 | 1136-1141 | PG_18;PG_1 | denotes | spike |
| T531 | 1142-1154 | PG_18;PG_1;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T532 | 1214-1219 | PG_18;PG_1 | denotes | spike |
| T533 | 1220-1232 | PG_18;PG_1;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T534 | 1270-1283 | NCBITaxon:11118 | denotes | coronaviruses |
| T535 | 1295-1299 | NCBITaxon:10088 | denotes | mice |
| T536 | 1383-1393 | SP_7 | denotes | SARS-CoV-2 |
| T537 | 1402-1410 | SP_7 | denotes | COVID-19 |
| T538 | 1529-1533 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T539 | 1542-1552 | SP_7 | denotes | SARS-CoV-2 |
| T540 | 1559-1569 | SP_7 | denotes | SARS-CoV-2 |
| T541 | 1820-1830 | SP_7 | denotes | SARS-CoV-2 |
| T24925 | 224-235 | GO:0006260 | denotes | replication |
| T90899 | 239-247 | SP_10 | denotes | SARS-CoV |
| T4188 | 257-263 | NCBITaxon:33208 | denotes | animal |
| T29116 | 348-356 | SP_10 | denotes | SARS-CoV |
| T10981 | 361-369 | SP_9 | denotes | MERS-CoV |
| T36455 | 405-412 | NCBITaxon:33208 | denotes | animals |
| T52081 | 414-418 | NCBITaxon:10088 | denotes | Mice |
| T51597 | 454-458 | SP_9 | denotes | MERS |
| T7677 | 459-470 | NCBITaxon:11118 | denotes | coronavirus |
| T35940 | 507-511 | PG_7;PR:000001341 | denotes | DPP4 |
| T77876 | 541-547 | SO:0001026 | denotes | genome |
| T63643 | 566-577 | NCBITaxon:11118 | denotes | coronavirus |
| T83402 | 619-624 | SP_6;NCBITaxon:9606 | denotes | human |
| T1123 | 625-629 | SP_10 | denotes | SARS |
| T60885 | 635-638 | SP_2 | denotes | bat |
| T43154 | 660-666 | NCBITaxon:33208 | denotes | animal |
| T33239 | 678-686 | SP_10 | denotes | SARS-CoV |
| T83669 | 727-740 | BV_19 | denotes | pathogenicity |
| T52839 | 744-754 | SP_7 | denotes | SARS-CoV-2 |
| T60238 | 760-765 | SP_6;NCBITaxon:9606;PG_10 | denotes | human |
| T11918 | 766-770 | PG_10;PR:000003622 | denotes | ACE2 |
| T79402 | 807-811 | SP_10 | denotes | SARS |
| T21220 | 822-835 | NCBITaxon:11118 | denotes | coronaviruses |
| T57308 | 876-887 | SO:0000704 | denotes | genetically |
| T10633 | 921-928 | NCBITaxon:33208 | denotes | animals |
| T34926 | 966-979 | BV_19 | denotes | pathogenicity |
| T50129 | 989-1002 | NCBITaxon:11118 | denotes | coronaviruses |
| T27200 | 1004-1012 | SP_10 | denotes | SARS-CoV |
| T81676 | 1072-1076 | NCBITaxon:10114 | denotes | Rats |
| T27140 | 1136-1141 | PG_18;PG_1 | denotes | spike |
| T88686 | 1142-1154 | PG_18;PG_1;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T26353 | 1214-1219 | PG_18;PG_1 | denotes | spike |
| T93581 | 1220-1232 | PG_18;PG_1;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T65567 | 1270-1283 | NCBITaxon:11118 | denotes | coronaviruses |
| T94636 | 1295-1299 | NCBITaxon:10088 | denotes | mice |
| T69665 | 1383-1393 | SP_7 | denotes | SARS-CoV-2 |
| T22414 | 1402-1410 | SP_7 | denotes | COVID-19 |
| T37578 | 1529-1533 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T56066 | 1542-1552 | SP_7 | denotes | SARS-CoV-2 |
| T88326 | 1559-1569 | SP_7 | denotes | SARS-CoV-2 |
| T55978 | 1820-1830 | SP_7 | denotes | SARS-CoV-2 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32257431-24574399-54950105 | 522-524 | 24574399 | denotes | 44 |
| 32257431-17151094-54950106 | 1156-1158 | 17151094 | denotes | 45 |
| 32257431-31924756-54950107 | 1412-1414 | 31924756 | denotes | 46 |
| 32257431-31924756-54950108 | 1642-1644 | 31924756 | denotes | 46 |
| 32257431-31745213-54950109 | 1648-1650 | 31745213 | denotes | 49 |