PMC:7105881 / 45150-45597 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1397","span":{"begin":17,"end":22},"obj":"Gene"},{"id":"1398","span":{"begin":61,"end":64},"obj":"Gene"},{"id":"1399","span":{"begin":216,"end":221},"obj":"Gene"},{"id":"1400","span":{"begin":223,"end":227},"obj":"Gene"},{"id":"1401","span":{"begin":229,"end":233},"obj":"Gene"},{"id":"1402","span":{"begin":235,"end":240},"obj":"Gene"},{"id":"1403","span":{"begin":246,"end":252},"obj":"Gene"},{"id":"1405","span":{"begin":287,"end":292},"obj":"Gene"},{"id":"1479","span":{"begin":7,"end":11},"obj":"Species"},{"id":"1480","span":{"begin":23,"end":27},"obj":"Species"},{"id":"1481","span":{"begin":37,"end":45},"obj":"Species"},{"id":"1482","span":{"begin":83,"end":87},"obj":"Species"},{"id":"1483","span":{"begin":130,"end":138},"obj":"Species"},{"id":"1484","span":{"begin":165,"end":173},"obj":"Species"},{"id":"1485","span":{"begin":257,"end":261},"obj":"Species"},{"id":"1486","span":{"begin":304,"end":308},"obj":"Species"},{"id":"1487","span":{"begin":327,"end":335},"obj":"Species"},{"id":"1500","span":{"begin":375,"end":393},"obj":"Disease"}],"attributes":[{"id":"A1397","pred":"tao:has_database_id","subj":"1397","obj":"Gene:1803"},{"id":"A1398","pred":"tao:has_database_id","subj":"1398","obj":"Gene:51428"},{"id":"A1399","pred":"tao:has_database_id","subj":"1399","obj":"Gene:3458"},{"id":"A1400","pred":"tao:has_database_id","subj":"1400","obj":"Gene:3558"},{"id":"A1401","pred":"tao:has_database_id","subj":"1401","obj":"Gene:3569"},{"id":"A1402","pred":"tao:has_database_id","subj":"1402","obj":"Gene:3586"},{"id":"A1403","pred":"tao:has_database_id","subj":"1403","obj":"Gene:3605"},{"id":"A1405","pred":"tao:has_database_id","subj":"1405","obj":"Gene:1803"},{"id":"A1479","pred":"tao:has_database_id","subj":"1479","obj":"Tax:10090"},{"id":"A1480","pred":"tao:has_database_id","subj":"1480","obj":"Tax:10090"},{"id":"A1481","pred":"tao:has_database_id","subj":"1481","obj":"Tax:1335626"},{"id":"A1482","pred":"tao:has_database_id","subj":"1482","obj":"Tax:10090"},{"id":"A1483","pred":"tao:has_database_id","subj":"1483","obj":"Tax:1335626"},{"id":"A1484","pred":"tao:has_database_id","subj":"1484","obj":"Tax:1335626"},{"id":"A1485","pred":"tao:has_database_id","subj":"1485","obj":"Tax:10090"},{"id":"A1486","pred":"tao:has_database_id","subj":"1486","obj":"Tax:10090"},{"id":"A1487","pred":"tao:has_database_id","subj":"1487","obj":"Tax:1335626"},{"id":"A1500","pred":"tao:has_database_id","subj":"1500","obj":"MESH:D008171"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T271","span":{"begin":66,"end":69},"obj":"Body_part"},{"id":"T272","span":{"begin":223,"end":227},"obj":"Body_part"},{"id":"T273","span":{"begin":375,"end":379},"obj":"Body_part"},{"id":"T274","span":{"begin":398,"end":415},"obj":"Body_part"}],"attributes":[{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma265130"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T15","span":{"begin":375,"end":379},"obj":"Body_part"},{"id":"T16","span":{"begin":398,"end":415},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T237","span":{"begin":13,"end":16},"obj":"Disease"},{"id":"T238","span":{"begin":48,"end":51},"obj":"Disease"},{"id":"T240","span":{"begin":176,"end":179},"obj":"Disease"},{"id":"T242","span":{"begin":283,"end":286},"obj":"Disease"}],"attributes":[{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0011194"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A239","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A241","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0011194"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T578","span":{"begin":223,"end":227},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T579","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T580","span":{"begin":375,"end":379},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T295","span":{"begin":223,"end":225},"obj":"Chemical"},{"id":"T297","span":{"begin":229,"end":231},"obj":"Chemical"},{"id":"T299","span":{"begin":235,"end":237},"obj":"Chemical"},{"id":"T301","span":{"begin":246,"end":248},"obj":"Chemical"}],"attributes":[{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A296","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A298","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A300","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A302","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T91","span":{"begin":189,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T92","span":{"begin":189,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T93","span":{"begin":189,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0002443"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"2_test","denotations":[{"id":"32265848-27899228-36511187","span":{"begin":443,"end":447},"obj":"27899228"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}

{"project":"LitCovid-sentences","denotations":[{"id":"T257","span":{"begin":0,"end":447},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"BALB/c mice; Ad5-hDPP4 mice Elicits MERS-CoV S-NTD-specific Abs (IgG, ≥ 1:104) in mice, neutralizing pseudotyped and live (1:40) MERS-CoV (EMC2012 strain) Induces MERS-CoV S-NTD-specific cellular immune responses (IFN-γ, IL-2, IL-6, IL-10, and IL-17A) in mice Protects vaccinated Ad5-hDPP4-transduced mice from challenge of MERS-CoV (EMC2012 strain, 105 PFU) with reduced lung abnormalities and respiratory tract pathology Jiaming et al., 2017"}