PMC:7105881 / 29255-29925 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"900","span":{"begin":101,"end":105},"obj":"Gene"},{"id":"901","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"902","span":{"begin":235,"end":240},"obj":"Gene"},{"id":"903","span":{"begin":405,"end":408},"obj":"Gene"},{"id":"916","span":{"begin":464,"end":467},"obj":"Gene"},{"id":"917","span":{"begin":91,"end":94},"obj":"Gene"},{"id":"966","span":{"begin":59,"end":63},"obj":"Species"},{"id":"967","span":{"begin":73,"end":81},"obj":"Species"},{"id":"968","span":{"begin":121,"end":125},"obj":"Species"},{"id":"969","span":{"begin":188,"end":196},"obj":"Species"},{"id":"970","span":{"begin":245,"end":249},"obj":"Species"},{"id":"971","span":{"begin":316,"end":324},"obj":"Species"},{"id":"972","span":{"begin":431,"end":435},"obj":"Species"},{"id":"973","span":{"begin":444,"end":452},"obj":"Species"},{"id":"974","span":{"begin":486,"end":490},"obj":"Species"},{"id":"975","span":{"begin":551,"end":568},"obj":"Species"},{"id":"976","span":{"begin":601,"end":605},"obj":"Species"},{"id":"977","span":{"begin":624,"end":640},"obj":"Species"}],"attributes":[{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"Gene:16017"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"Gene:668478"},{"id":"A902","pred":"tao:has_database_id","subj":"902","obj":"Gene:3458"},{"id":"A903","pred":"tao:has_database_id","subj":"903","obj":"Gene:4352"},{"id":"A916","pred":"tao:has_database_id","subj":"916","obj":"Gene:51428"},{"id":"A917","pred":"tao:has_database_id","subj":"917","obj":"Gene:51428"},{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Tax:10090"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"Tax:694009"},{"id":"A968","pred":"tao:has_database_id","subj":"968","obj":"Tax:10090"},{"id":"A969","pred":"tao:has_database_id","subj":"969","obj":"Tax:694009"},{"id":"A970","pred":"tao:has_database_id","subj":"970","obj":"Tax:10090"},{"id":"A971","pred":"tao:has_database_id","subj":"971","obj":"Tax:694009"},{"id":"A972","pred":"tao:has_database_id","subj":"972","obj":"Tax:10090"},{"id":"A973","pred":"tao:has_database_id","subj":"973","obj":"Tax:694009"},{"id":"A974","pred":"tao:has_database_id","subj":"974","obj":"Tax:10090"},{"id":"A975","pred":"tao:has_database_id","subj":"975","obj":"Tax:228330"},{"id":"A976","pred":"tao:has_database_id","subj":"976","obj":"Tax:10090"},{"id":"A977","pred":"tao:has_database_id","subj":"977","obj":"Tax:228330"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T140","span":{"begin":10,"end":17},"obj":"Body_part"},{"id":"T141","span":{"begin":96,"end":99},"obj":"Body_part"},{"id":"T142","span":{"begin":327,"end":334},"obj":"Body_part"},{"id":"T143","span":{"begin":362,"end":370},"obj":"Body_part"},{"id":"T144","span":{"begin":469,"end":472},"obj":"Body_part"}],"attributes":[{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T141","span":{"begin":73,"end":81},"obj":"Disease"},{"id":"T142","span":{"begin":188,"end":196},"obj":"Disease"},{"id":"T143","span":{"begin":316,"end":324},"obj":"Disease"},{"id":"T144","span":{"begin":444,"end":452},"obj":"Disease"},{"id":"T145","span":{"begin":551,"end":559},"obj":"Disease"},{"id":"T146","span":{"begin":624,"end":632},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T371","span":{"begin":21,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T372","span":{"begin":253,"end":254},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T373","span":{"begin":345,"end":347},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T374","span":{"begin":352,"end":354},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T375","span":{"begin":374,"end":375},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T376","span":{"begin":514,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T377","span":{"begin":522,"end":524},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T378","span":{"begin":535,"end":537},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T379","span":{"begin":579,"end":580},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T139","span":{"begin":10,"end":17},"obj":"Chemical"},{"id":"T140","span":{"begin":327,"end":334},"obj":"Chemical"},{"id":"T141","span":{"begin":362,"end":370},"obj":"Chemical"},{"id":"T142","span":{"begin":386,"end":390},"obj":"Chemical"}],"attributes":[{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_29287"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T53","span":{"begin":165,"end":178},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T54","span":{"begin":208,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T55","span":{"begin":208,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T56","span":{"begin":208,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0002443"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"2_test","denotations":[{"id":"32265848-16919855-36511122","span":{"begin":277,"end":281},"obj":"16919855"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}

{"project":"LitCovid-sentences","denotations":[{"id":"T175","span":{"begin":1,"end":46},"obj":"Sentence"},{"id":"T176","span":{"begin":48,"end":126},"obj":"Sentence"},{"id":"T177","span":{"begin":127,"end":281},"obj":"Sentence"},{"id":"T178","span":{"begin":282,"end":344},"obj":"Sentence"},{"id":"T179","span":{"begin":345,"end":422},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"\nS318-510 protein N/A Alum; Alum + CpG S.C. 129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007\nSubunit vaccines based on non-RBD SARS-CoV S protein fragments\nS1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, \u003e 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with unde"}