PMC:7105881 / 24461-25138
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7105881","sourcedb":"PMC","sourceid":"7105881","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7105881","text":", and/or protection than the other regions, such as full-length, S1, and RBD (Guo et al., 2005; Jiaming et al., 2017). Therefore, in terms of safety and efficacy, the RBD and/or S1 of S protein could be applied as critical targets for the development of subunit vaccine candidates against SARS-CoV, MERS-CoV, SARSr-CoV, and MERSr-CoV. Because of its conserved amino acid sequences and high homology among different virus strains (Elshabrawy et al., 2012; Zhou et al., 2018), the S2 subunit has potential to be used as a target for the development of universal vaccines against divergent virus strains.\nIn addition to the S protein, the N protein of SARS-CoV and MERS-CoV may se","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"739","span":{"begin":289,"end":297},"obj":"Species"},{"id":"740","span":{"begin":299,"end":307},"obj":"Species"},{"id":"741","span":{"begin":309,"end":318},"obj":"Species"},{"id":"742","span":{"begin":330,"end":333},"obj":"Species"},{"id":"757","span":{"begin":649,"end":657},"obj":"Species"},{"id":"758","span":{"begin":662,"end":670},"obj":"Species"}],"attributes":[{"id":"A739","pred":"tao:has_database_id","subj":"739","obj":"Tax:694009"},{"id":"A740","pred":"tao:has_database_id","subj":"740","obj":"Tax:1335626"},{"id":"A741","pred":"tao:has_database_id","subj":"741","obj":"Tax:694009"},{"id":"A742","pred":"tao:has_database_id","subj":"742","obj":"Tax:11118"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"Tax:694009"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"Tax:1335626"},{"subj":"739","pred":"source","obj":"LitCovid-PubTator"},{"subj":"740","pred":"source","obj":"LitCovid-PubTator"},{"subj":"741","pred":"source","obj":"LitCovid-PubTator"},{"subj":"742","pred":"source","obj":"LitCovid-PubTator"},{"subj":"757","pred":"source","obj":"LitCovid-PubTator"},{"subj":"758","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T99","span":{"begin":186,"end":193},"obj":"Body_part"},{"id":"T100","span":{"begin":360,"end":370},"obj":"Body_part"},{"id":"T101","span":{"begin":623,"end":630},"obj":"Body_part"},{"id":"T102","span":{"begin":638,"end":645},"obj":"Body_part"}],"attributes":[{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A100","pred":"fma_id","subj":"T100","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T104","span":{"begin":289,"end":297},"obj":"Disease"},{"id":"T105","span":{"begin":649,"end":657},"obj":"Disease"}],"attributes":[{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T255","span":{"begin":65,"end":67},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T256","span":{"begin":178,"end":180},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T257","span":{"begin":415,"end":420},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T258","span":{"begin":468,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T259","span":{"begin":479,"end":481},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T260","span":{"begin":479,"end":481},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T261","span":{"begin":490,"end":493},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T262","span":{"begin":518,"end":519},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T263","span":{"begin":587,"end":592},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T104","span":{"begin":78,"end":81},"obj":"Chemical"},{"id":"T105","span":{"begin":186,"end":193},"obj":"Chemical"},{"id":"T106","span":{"begin":360,"end":370},"obj":"Chemical"},{"id":"T107","span":{"begin":360,"end":365},"obj":"Chemical"},{"id":"T108","span":{"begin":366,"end":370},"obj":"Chemical"},{"id":"T109","span":{"begin":479,"end":481},"obj":"Chemical"},{"id":"T110","span":{"begin":623,"end":630},"obj":"Chemical"},{"id":"T111","span":{"begin":638,"end":645},"obj":"Chemical"}],"attributes":[{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_16750"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A106","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A107","pred":"chebi_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A109","pred":"chebi_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A110","pred":"chebi_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"2_test","denotations":[{"id":"32265848-16101349-36511104","span":{"begin":90,"end":94},"obj":"16101349"},{"id":"32265848-27899228-36511105","span":{"begin":112,"end":116},"obj":"27899228"},{"id":"32265848-23185609-36511106","span":{"begin":449,"end":453},"obj":"23185609"},{"id":"32265848-30058403-36511107","span":{"begin":468,"end":472},"obj":"30058403"}],"attributes":[{"subj":"32265848-16101349-36511104","pred":"source","obj":"2_test"},{"subj":"32265848-27899228-36511105","pred":"source","obj":"2_test"},{"subj":"32265848-23185609-36511106","pred":"source","obj":"2_test"},{"subj":"32265848-30058403-36511107","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T148","span":{"begin":119,"end":334},"obj":"Sentence"},{"id":"T149","span":{"begin":335,"end":601},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T148","pred":"source","obj":"LitCovid-sentences"},{"subj":"T149","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T467","span":{"begin":184,"end":185},"obj":"PR:000005292;PG_1"},{"id":"T468","span":{"begin":186,"end":193},"obj":"PG_1"},{"id":"T469","span":{"begin":289,"end":297},"obj":"SP_10"},{"id":"T470","span":{"begin":299,"end":307},"obj":"SP_9"},{"id":"T471","span":{"begin":390,"end":398},"obj":"SO:0000853"},{"id":"T472","span":{"begin":415,"end":420},"obj":"NCBITaxon:10239"},{"id":"T473","span":{"begin":587,"end":592},"obj":"NCBITaxon:10239"},{"id":"T474","span":{"begin":621,"end":630},"obj":"PG_1"},{"id":"T475","span":{"begin":636,"end":645},"obj":"PG_4"},{"id":"T476","span":{"begin":649,"end":657},"obj":"SP_10"},{"id":"T477","span":{"begin":662,"end":670},"obj":"SP_9"},{"id":"T62168","span":{"begin":184,"end":185},"obj":"PR:000005292;PG_1"},{"id":"T88215","span":{"begin":186,"end":193},"obj":"PG_1"},{"id":"T28940","span":{"begin":289,"end":297},"obj":"SP_10"},{"id":"T73058","span":{"begin":299,"end":307},"obj":"SP_9"},{"id":"T54443","span":{"begin":390,"end":398},"obj":"SO:0000853"},{"id":"T50150","span":{"begin":415,"end":420},"obj":"NCBITaxon:10239"},{"id":"T15099","span":{"begin":587,"end":592},"obj":"NCBITaxon:10239"},{"id":"T74894","span":{"begin":621,"end":630},"obj":"PG_1"},{"id":"T15381","span":{"begin":636,"end":645},"obj":"PG_4"},{"id":"T26723","span":{"begin":649,"end":657},"obj":"SP_10"},{"id":"T6926","span":{"begin":662,"end":670},"obj":"SP_9"}],"attributes":[{"subj":"T467","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T468","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T469","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T470","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T471","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T472","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T473","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T474","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T475","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T476","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T477","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62168","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88215","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28940","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73058","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T54443","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50150","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15099","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T74894","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15381","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26723","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6926","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#eca193","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#939eec"},{"id":"LitCovid-PD-MONDO","color":"#b8ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93d2"},{"id":"LitCovid-PD-CHEBI","color":"#93ecec"},{"id":"2_test","color":"#ecd293"},{"id":"LitCovid-sentences","color":"#b893ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ec9d"}]}]}}