PMC:7105881 / 16155-17597
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
555 | 268-290 | Gene | denotes | dipeptidyl peptidase 4 | Gene:1803 |
556 | 292-296 | Gene | denotes | DPP4 | Gene:1803 |
557 | 406-410 | Gene | denotes | ACE2 | Gene:59272 |
558 | 754-758 | Gene | denotes | DPP4 | Gene:1803 |
559 | 981-985 | Gene | denotes | DPP4 | Gene:1803 |
560 | 1120-1124 | Gene | denotes | DPP4 | Gene:1803 |
561 | 1386-1390 | Gene | denotes | DPP4 | Gene:1803 |
562 | 0-8 | Species | denotes | MERS-CoV | Tax:1335626 |
563 | 135-143 | Species | denotes | SARS-CoV | Tax:694009 |
564 | 211-219 | Species | denotes | MERS-CoV | Tax:1335626 |
565 | 250-258 | Species | denotes | MERS-CoV | Tax:1335626 |
566 | 388-396 | Species | denotes | SARS-CoV | Tax:694009 |
567 | 441-449 | Species | denotes | SARS-CoV | Tax:694009 |
568 | 454-462 | Species | denotes | MERS-CoV | Tax:1335626 |
569 | 594-602 | Species | denotes | MERS-CoV | Tax:1335626 |
570 | 658-666 | Species | denotes | SARS-CoV | Tax:694009 |
571 | 731-739 | Species | denotes | MERS-CoV | Tax:1335626 |
572 | 834-842 | Species | denotes | MERS-CoV | Tax:1335626 |
573 | 975-980 | Species | denotes | human | Tax:9606 |
574 | 1050-1054 | Species | denotes | CoVs | Tax:11118 |
575 | 1062-1066 | Species | denotes | CoVs | Tax:11118 |
576 | 1114-1119 | Species | denotes | human | Tax:9606 |
577 | 1232-1235 | Species | denotes | CoV | Tax:11118 |
578 | 1249-1254 | Species | denotes | human | Tax:9606 |
579 | 1323-1331 | Species | denotes | MERS-CoV | Tax:1335626 |
580 | 871-875 | Species | denotes | HKU4 | Tax:694007 |
581 | 890-894 | Species | denotes | HKU5 | Tax:290028 |
582 | 935-939 | Species | denotes | HKU4 | Tax:694007 |
583 | 959-963 | Species | denotes | HKU5 | Tax:290028 |
584 | 74-82 | Species | denotes | SARS-CoV | Tax:694009 |
585 | 925-927 | Chemical | denotes | Ty |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T77 | 1136-1141 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T78 | 1334-1341 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T59 | 74-82 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T60 | 135-143 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T61 | 388-396 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T62 | 441-449 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T63 | 658-666 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T193 | 20-21 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T194 | 199-207 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T195 | 301-302 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T196 | 583-585 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
T197 | 583-585 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
T198 | 627-628 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T199 | 975-980 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T200 | 989-990 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T201 | 1094-1098 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bats |
T202 | 1114-1119 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T203 | 1136-1141 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T204 | 1155-1159 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
T205 | 1249-1254 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T74 | 583-585 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
T75 | 880-882 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T76 | 949-951 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T77 | 1143-1146 | Chemical | denotes | Lau | http://purl.obolibrary.org/obo/CHEBI_32359 |
T78 | 1334-1341 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32265848-23835475-36511060 | 97-101 | 23835475 | denotes | 2013 |
32265848-23486063-36511062 | 354-358 | 23486063 | denotes | 2013 |
32265848-25428871-36511063 | 587-591 | 25428871 | denotes | 2015 |
32265848-28807998-36511064 | 808-812 | 28807998 | denotes | 2017 |
32265848-28393837-36511065 | 827-831 | 28393837 | denotes | 2017 |
32265848-29346682-36511067 | 1155-1159 | 29346682 | denotes | 2018 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T99 | 0-103 | Sentence | denotes | MERS-CoV RBD shares a structure similar to that of the homology domain of SARS-CoV (Wang et al., 2013). |
T100 | 104-239 | Sentence | denotes | However, antibodies induced by SARS-CoV RBD have no cross-reactivity and/or cross-neutralizing activity to MERS-CoV (Du et al., 2013b). |
T101 | 240-411 | Sentence | denotes | Moreover, MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4) as a receptor through the RBD (CTD) region (Raj et al., 2013), which is distinct from the SARS-CoV receptor ACE2. |
T102 | 412-593 | Sentence | denotes | Although the core regions of SARS-CoV and MERS-CoV RBDs are similar, their RBM regions are significantly different, which explains why they recognize different receptors (Li, 2015). |
T103 | 594-676 | Sentence | denotes | MERS-CoV S trimer also maintains a structure similar to that of SARS-CoV S trimer. |
T104 | 677-833 | Sentence | denotes | Both standing and lying states can be detected in the MERS-CoV RBDs, whereas DPP4 only binds to the standing RBD (Pallesen et al., 2017; Yuan et al., 2017). |
T105 | 834-924 | Sentence | denotes | MERS-CoV is clustered with Ty-BatCoV HKU4 and Pi-BatCoV HKU5 in the subgenus Merbecovirus. |
T106 | 925-1021 | Sentence | denotes | Ty-BatCoV HKU4, but not Pi-BatCoV HKU5, could use human DPP4 as a receptor (Yang et al., 2014b). |
T107 | 1022-1180 | Sentence | denotes | Recently, some MERS-related CoVs (MERSr-CoVs) have been discovered from bats that can enter human DPP4-expressing cells (Lau et al., 2018; Luo et al., 2018a). |
T108 | 1181-1318 | Sentence | denotes | These findings suggest that the emergence of MERSr-CoV may threaten human health owing to their potential for cross-species transmission. |
T109 | 1319-1442 | Sentence | denotes | The MERS-CoV S protein and RBD and their complexes, along with the DPP4 receptor, are shown in Supplementary Figures S1C,D. |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T302 | 0-8 | SP_9 | denotes | MERS-CoV |
T303 | 55-63 | SO:0000853 | denotes | homology |
T304 | 64-70 | SO:0000417 | denotes | domain |
T305 | 74-82 | SP_10 | denotes | SARS-CoV |
T306 | 113-123 | GO:0042571 | denotes | antibodies |
T307 | 135-143 | SP_10 | denotes | SARS-CoV |
T308 | 211-219 | SP_9 | denotes | MERS-CoV |
T309 | 250-258 | SP_9 | denotes | MERS-CoV |
T310 | 279-290 | PR:000012546 | denotes | peptidase 4 |
T311 | 292-296 | PR:000001341;PG_7 | denotes | DPP4 |
T312 | 388-396 | SP_10 | denotes | SARS-CoV |
T313 | 406-410 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T314 | 441-449 | SP_10 | denotes | SARS-CoV |
T315 | 454-462 | SP_9 | denotes | MERS-CoV |
T316 | 594-602 | SP_9 | denotes | MERS-CoV |
T317 | 658-666 | SP_10 | denotes | SARS-CoV |
T318 | 731-739 | SP_9 | denotes | MERS-CoV |
T319 | 754-758 | PG_7;PR:000001341 | denotes | DPP4 |
T320 | 834-842 | SP_9 | denotes | MERS-CoV |
T321 | 975-980 | SP_6;NCBITaxon:9606 | denotes | human |
T322 | 981-985 | PG_7;PR:000001341 | denotes | DPP4 |
T323 | 1037-1041 | SP_9 | denotes | MERS |
T324 | 1094-1098 | SP_2;NCBITaxon:8342 | denotes | bats |
T325 | 1114-1119 | SP_6;NCBITaxon:9606 | denotes | human |
T326 | 1120-1124 | PG_7;PR:000001341 | denotes | DPP4 |
T327 | 1125-1135 | GO:0010467 | denotes | expressing |
T328 | 1249-1254 | SP_6;NCBITaxon:9606 | denotes | human |
T329 | 1297-1304 | NCBITaxon:species | denotes | species |
T330 | 1323-1331 | SP_9 | denotes | MERS-CoV |
T331 | 1332-1341 | PG_1 | denotes | S protein |
T332 | 1360-1369 | GO:0032991 | denotes | complexes |
T333 | 1386-1390 | PG_7;PR:000001341 | denotes | DPP4 |
T29983 | 0-8 | SP_9 | denotes | MERS-CoV |
T17057 | 55-63 | SO:0000853 | denotes | homology |
T32008 | 64-70 | SO:0000417 | denotes | domain |
T56589 | 74-82 | SP_10 | denotes | SARS-CoV |
T57877 | 113-123 | GO:0042571 | denotes | antibodies |
T96396 | 135-143 | SP_10 | denotes | SARS-CoV |
T84761 | 211-219 | SP_9 | denotes | MERS-CoV |
T4692 | 250-258 | SP_9 | denotes | MERS-CoV |
T69481 | 279-290 | PR:000012546 | denotes | peptidase 4 |
T91688 | 292-296 | PR:000001341;PG_7 | denotes | DPP4 |
T56470 | 388-396 | SP_10 | denotes | SARS-CoV |
T53532 | 406-410 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T12186 | 441-449 | SP_10 | denotes | SARS-CoV |
T61058 | 454-462 | SP_9 | denotes | MERS-CoV |
T96781 | 594-602 | SP_9 | denotes | MERS-CoV |
T61210 | 658-666 | SP_10 | denotes | SARS-CoV |
T31903 | 731-739 | SP_9 | denotes | MERS-CoV |
T62435 | 754-758 | PG_7;PR:000001341 | denotes | DPP4 |
T27691 | 834-842 | SP_9 | denotes | MERS-CoV |
T96680 | 975-980 | SP_6;NCBITaxon:9606 | denotes | human |
T87087 | 981-985 | PG_7;PR:000001341 | denotes | DPP4 |
T52550 | 1037-1041 | SP_9 | denotes | MERS |
T37578 | 1094-1098 | SP_2;NCBITaxon:8342 | denotes | bats |
T90449 | 1114-1119 | SP_6;NCBITaxon:9606 | denotes | human |
T19922 | 1120-1124 | PG_7;PR:000001341 | denotes | DPP4 |
T67319 | 1125-1135 | GO:0010467 | denotes | expressing |
T99843 | 1249-1254 | SP_6;NCBITaxon:9606 | denotes | human |
T78701 | 1297-1304 | NCBITaxon:species | denotes | species |
T14528 | 1323-1331 | SP_9 | denotes | MERS-CoV |
T7216 | 1332-1341 | PG_1 | denotes | S protein |
T77879 | 1360-1369 | GO:0032991 | denotes | complexes |
T55323 | 1386-1390 | PG_7;PR:000001341 | denotes | DPP4 |