
PMC:7103735 / 44837-45706
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T190 | 154-158 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T191 | 154-156 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T192 | 225-229 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T193 | 225-227 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T194 | 330-338 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T195 | 594-598 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T196 | 594-596 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T197 | 638-645 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T198 | 700-704 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T199 | 700-702 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T200 | 706-719 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
T201 | 726-745 | Body_part | denotes | lipopolysaccharides | http://purl.org/sig/ont/fma/fma82785 |
T202 | 793-800 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T414 | 19-27 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T415 | 19-23 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T416 | 61-69 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T417 | 61-65 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T418 | 410-413 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T419 | 601-604 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T420 | 659-663 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T501 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T502 | 49-59 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T503 | 74-82 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T504 | 88-94 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T505 | 111-117 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T506 | 121-131 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T507 | 193-194 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T508 | 195-205 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T509 | 495-504 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
T510 | 512-522 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
T511 | 657-658 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T512 | 690-691 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T513 | 706-719 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
T514 | 814-815 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T181 | 154-156 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T183 | 189-191 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T186 | 225-227 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T188 | 282-291 | Chemical | denotes | potassium | http://purl.obolibrary.org/obo/CHEBI_26216 |
T189 | 292-295 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
T190 | 330-338 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T191 | 594-596 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T193 | 638-645 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T194 | 700-702 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T196 | 721-724 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
T199 | 726-745 | Chemical | denotes | lipopolysaccharides | http://purl.obolibrary.org/obo/CHEBI_16412 |
T200 | 793-800 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T201 | 810-812 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T95 | 160-173 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T96 | 296-302 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T97 | 296-302 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T98 | 606-615 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T99 | 606-615 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T100 | 851-859 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
T101 | 851-859 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
T102 | 851-859 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
T103 | 851-859 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T369 | 0-60 | Sentence | denotes | A working model of SARS-CoV-induced inflammasome activation. |
T370 | 61-133 | Sentence | denotes | SARS-CoV can activate both signal 1 (priming) and signal 2 (activation). |
T371 | 134-206 | Sentence | denotes | Upregulation of pro-IL-1β transcription is achieved by NF-κB activation. |
T372 | 207-261 | Sentence | denotes | Two mechanisms of IL-1β maturation have been proposed. |
T373 | 262-379 | Sentence | denotes | In the first model, potassium ion efflux is promoted by ORF3a and E proteins, leading to NLRP3 inflammasome assembly. |
T374 | 380-469 | Sentence | denotes | Alternatively, ORF3a promotes ASC ubiquitination and consequent assembly of inflammasome. |
T375 | 470-511 | Sentence | denotes | ORG8b interacts with and activates NLRP3. |
T376 | 512-600 | Sentence | denotes | Activation of inflammasome leads to proteolytic cleavage of pro-caspase 1 and pro-IL-1β. |
T377 | 601-664 | Sentence | denotes | ASC, apoptosis-associated speck-like protein containing a CARD. |
T378 | 665-682 | Sentence | denotes | CASP1, caspase 1. |
T379 | 683-699 | Sentence | denotes | IKK, IκB kinase. |
T380 | 700-720 | Sentence | denotes | IL-1, interleukin-1. |
T381 | 721-746 | Sentence | denotes | LPS, lipopolysaccharides. |
T382 | 747-803 | Sentence | denotes | NLRP3, NACHT, LRR, and PYD domains-containing protein 3. |
T383 | 804-836 | Sentence | denotes | NEMO, NF-κB essential modulator. |
T384 | 837-869 | Sentence | denotes | TNF-α, tumour necrosis factor α. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T33 | 844-850 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1224 | 150-159 | Gene | denotes | pro-IL-1β | Gene:3553 |
1225 | 189-194 | Gene | denotes | NF-κB | Gene:4790 |
1226 | 225-230 | Gene | denotes | IL-1β | Gene:3552 |
1227 | 351-356 | Gene | denotes | NLRP3 | Gene:114548 |
1228 | 505-510 | Gene | denotes | NLRP3 | Gene:114548 |
1229 | 590-599 | Gene | denotes | pro-IL-1β | Gene:3553 |
1230 | 601-604 | Gene | denotes | ASC | Gene:29108 |
1231 | 606-663 | Gene | denotes | apoptosis-associated speck-like protein containing a CARD | Gene:29108 |
1232 | 665-670 | Gene | denotes | CASP1 | Gene:834 |
1233 | 672-681 | Gene | denotes | caspase 1 | Gene:834 |
1234 | 683-686 | Gene | denotes | IKK | Gene:8517 |
1235 | 700-704 | Gene | denotes | IL-1 | Gene:3552 |
1236 | 706-719 | Gene | denotes | interleukin-1 | Gene:3552 |
1237 | 747-752 | Gene | denotes | NLRP3 | Gene:114548 |
1238 | 754-802 | Gene | denotes | NACHT, LRR, and PYD domains-containing protein 3 | Gene:114548 |
1239 | 804-808 | Gene | denotes | NEMO | Gene:8517 |
1240 | 810-815 | Gene | denotes | NF-κB | Gene:4790 |
1241 | 837-842 | Gene | denotes | TNF-α | Gene:7124 |
1242 | 19-27 | Species | denotes | SARS-CoV | Tax:694009 |
1243 | 61-69 | Species | denotes | SARS-CoV | Tax:694009 |
1244 | 410-413 | Gene | denotes | ASC | Gene:29108 |
1245 | 282-291 | Chemical | denotes | potassium | MESH:D011188 |
1246 | 726-745 | Chemical | denotes | lipopolysaccharides | MESH:D008070 |
1247 | 844-859 | Disease | denotes | tumour necrosis | MESH:D009336 |