PMC:7103735 / 44827-45706
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T190 | 164-168 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T191 | 164-166 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T192 | 235-239 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T193 | 235-237 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T194 | 340-348 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T195 | 604-608 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T196 | 604-606 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T197 | 648-655 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T198 | 710-714 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T199 | 710-712 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T200 | 716-729 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
T201 | 736-755 | Body_part | denotes | lipopolysaccharides | http://purl.org/sig/ont/fma/fma82785 |
T202 | 803-810 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T414 | 29-37 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T415 | 29-33 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T416 | 71-79 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T417 | 71-75 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T418 | 420-423 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T419 | 611-614 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T420 | 669-673 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T501 | 10-11 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T502 | 59-69 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T503 | 84-92 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T504 | 98-104 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T505 | 121-127 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T506 | 131-141 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T507 | 203-204 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T508 | 205-215 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T509 | 505-514 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
T510 | 522-532 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
T511 | 667-668 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T512 | 700-701 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T513 | 716-729 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
T514 | 824-825 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T181 | 164-166 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T183 | 199-201 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T186 | 235-237 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T188 | 292-301 | Chemical | denotes | potassium | http://purl.obolibrary.org/obo/CHEBI_26216 |
T189 | 302-305 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
T190 | 340-348 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T191 | 604-606 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T193 | 648-655 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T194 | 710-712 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T196 | 731-734 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
T199 | 736-755 | Chemical | denotes | lipopolysaccharides | http://purl.obolibrary.org/obo/CHEBI_16412 |
T200 | 803-810 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T201 | 820-822 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T95 | 170-183 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T96 | 306-312 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T97 | 306-312 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T98 | 616-625 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T99 | 616-625 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T100 | 861-869 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
T101 | 861-869 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
T102 | 861-869 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
T103 | 861-869 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T368 | 0-9 | Sentence | denotes | Figure 2. |
T369 | 10-70 | Sentence | denotes | A working model of SARS-CoV-induced inflammasome activation. |
T370 | 71-143 | Sentence | denotes | SARS-CoV can activate both signal 1 (priming) and signal 2 (activation). |
T371 | 144-216 | Sentence | denotes | Upregulation of pro-IL-1β transcription is achieved by NF-κB activation. |
T372 | 217-271 | Sentence | denotes | Two mechanisms of IL-1β maturation have been proposed. |
T373 | 272-389 | Sentence | denotes | In the first model, potassium ion efflux is promoted by ORF3a and E proteins, leading to NLRP3 inflammasome assembly. |
T374 | 390-479 | Sentence | denotes | Alternatively, ORF3a promotes ASC ubiquitination and consequent assembly of inflammasome. |
T375 | 480-521 | Sentence | denotes | ORG8b interacts with and activates NLRP3. |
T376 | 522-610 | Sentence | denotes | Activation of inflammasome leads to proteolytic cleavage of pro-caspase 1 and pro-IL-1β. |
T377 | 611-674 | Sentence | denotes | ASC, apoptosis-associated speck-like protein containing a CARD. |
T378 | 675-692 | Sentence | denotes | CASP1, caspase 1. |
T379 | 693-709 | Sentence | denotes | IKK, IκB kinase. |
T380 | 710-730 | Sentence | denotes | IL-1, interleukin-1. |
T381 | 731-756 | Sentence | denotes | LPS, lipopolysaccharides. |
T382 | 757-813 | Sentence | denotes | NLRP3, NACHT, LRR, and PYD domains-containing protein 3. |
T383 | 814-846 | Sentence | denotes | NEMO, NF-κB essential modulator. |
T384 | 847-879 | Sentence | denotes | TNF-α, tumour necrosis factor α. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T33 | 854-860 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1224 | 160-169 | Gene | denotes | pro-IL-1β | Gene:3553 |
1225 | 199-204 | Gene | denotes | NF-κB | Gene:4790 |
1226 | 235-240 | Gene | denotes | IL-1β | Gene:3552 |
1227 | 361-366 | Gene | denotes | NLRP3 | Gene:114548 |
1228 | 515-520 | Gene | denotes | NLRP3 | Gene:114548 |
1229 | 600-609 | Gene | denotes | pro-IL-1β | Gene:3553 |
1230 | 611-614 | Gene | denotes | ASC | Gene:29108 |
1231 | 616-673 | Gene | denotes | apoptosis-associated speck-like protein containing a CARD | Gene:29108 |
1232 | 675-680 | Gene | denotes | CASP1 | Gene:834 |
1233 | 682-691 | Gene | denotes | caspase 1 | Gene:834 |
1234 | 693-696 | Gene | denotes | IKK | Gene:8517 |
1235 | 710-714 | Gene | denotes | IL-1 | Gene:3552 |
1236 | 716-729 | Gene | denotes | interleukin-1 | Gene:3552 |
1237 | 757-762 | Gene | denotes | NLRP3 | Gene:114548 |
1238 | 764-812 | Gene | denotes | NACHT, LRR, and PYD domains-containing protein 3 | Gene:114548 |
1239 | 814-818 | Gene | denotes | NEMO | Gene:8517 |
1240 | 820-825 | Gene | denotes | NF-κB | Gene:4790 |
1241 | 847-852 | Gene | denotes | TNF-α | Gene:7124 |
1242 | 29-37 | Species | denotes | SARS-CoV | Tax:694009 |
1243 | 71-79 | Species | denotes | SARS-CoV | Tax:694009 |
1244 | 420-423 | Gene | denotes | ASC | Gene:29108 |
1245 | 292-301 | Chemical | denotes | potassium | MESH:D011188 |
1246 | 736-755 | Chemical | denotes | lipopolysaccharides | MESH:D008070 |
1247 | 854-869 | Disease | denotes | tumour necrosis | MESH:D009336 |