PMC:7103735 / 39766-41204 JSONTXT

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The first CoV phosphodiesterase identified is NS2a in mouse hepatitis virus. From protein sequence alignment, multiple CoVs including NS2a from OC43 and a bat CoV, as well as ORF4b encoded by MERS-CoV, are very similar to NS2a of mouse hepatitis virus. All these viral proteins preserve a phosphodiesterase activity [67]. This suggests that some CoVs have developed an important enzymatic activity through convergence and divergence. Hence, although most HCoVs retain one or another strategy to counter host antiviral defence, the highly pathogenic CoVs are particularly powerful in the suppression of host immunity. 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