PMC:7103735 / 39766-41204
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T142 | 49-57 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T143 | 537-540 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T144 | 559-562 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T145 | 589-592 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T146 | 646-651 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T147 | 832-839 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T148 | 1019-1027 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T377 | 810-819 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T378 | 986-995 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T444 | 108-118 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T445 | 220-230 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T446 | 369-370 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T447 | 393-394 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T448 | 405-406 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T449 | 431-440 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T450 | 646-651 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T451 | 672-680 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T452 | 742-743 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T453 | 804-809 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T454 | 820-825 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T455 | 903-904 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T456 | 905-908 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
| T457 | 980-985 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T458 | 996-1001 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T459 | 1037-1038 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T460 | 1057-1065 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T461 | 1139-1147 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T462 | 1431-1437 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T132 | 22-32 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T133 | 49-57 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T134 | 88-98 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T135 | 99-107 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T136 | 234-244 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T137 | 275-280 | Chemical | denotes | dsRNA | http://purl.obolibrary.org/obo/CHEBI_67208 |
| T138 | 612-622 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T139 | 832-839 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T140 | 1019-1027 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T141 | 1258-1267 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T61 | 22-43 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | interferon production |
| T62 | 108-118 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T63 | 282-295 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T64 | 372-381 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T65 | 460-477 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T66 | 460-477 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T67 | 612-633 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | interferon production |
| T68 | 1039-1065 | http://purl.obolibrary.org/obo/GO_0004528 | denotes | phosphodiesterase activity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T330 | 0-119 | Sentence | denotes | Apart from preventing interferon production, CoV proteins have also evolved to suppress interferon effector signalling. |
| T331 | 120-214 | Sentence | denotes | One of the best-characterized examples is the oligoadenylate synthetase (OAS)-RNase L pathway. |
| T332 | 215-387 | Sentence | denotes | Upon activation by interferon in response to the sensing of dsRNA, transcription and expression of OAS are induced to catalyse 2′,5′-oligoadenylate (2′-5′A) synthesis [65]. |
| T333 | 388-546 | Sentence | denotes | 2′-5′A serves as a second messenger, which activates RNase L and limits viral replication through the cleavage of cellular and viral single-stranded RNA [65]. |
| T334 | 547-652 | Sentence | denotes | The cleaved RNA fragments, in turn, prime RNA sensors to amplify interferon production in infected cells. |
| T335 | 653-749 | Sentence | denotes | To counter RNase L activity, some CoVs have evolved phosphodiesterases which cleave 2′-5′A [66]. |
| T336 | 750-826 | Sentence | denotes | The first CoV phosphodiesterase identified is NS2a in mouse hepatitis virus. |
| T337 | 827-1002 | Sentence | denotes | From protein sequence alignment, multiple CoVs including NS2a from OC43 and a bat CoV, as well as ORF4b encoded by MERS-CoV, are very similar to NS2a of mouse hepatitis virus. |
| T338 | 1003-1071 | Sentence | denotes | All these viral proteins preserve a phosphodiesterase activity [67]. |
| T339 | 1072-1183 | Sentence | denotes | This suggests that some CoVs have developed an important enzymatic activity through convergence and divergence. |
| T340 | 1184-1366 | Sentence | denotes | Hence, although most HCoVs retain one or another strategy to counter host antiviral defence, the highly pathogenic CoVs are particularly powerful in the suppression of host immunity. |
| T341 | 1367-1438 | Sentence | denotes | These capabilities might be weakened or lost when they adapt to humans. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T28 | 810-819 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T29 | 986-995 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-26231767-27782270 | 383-385 | 26231767 | denotes | 65 |
| 32172672-26231767-27782271 | 542-544 | 26231767 | denotes | 65 |
| 32172672-27743750-27782272 | 745-747 | 27743750 | denotes | 66 |
| 32172672-27025250-27782273 | 1067-1069 | 27025250 | denotes | 67 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1160 | 198-205 | Gene | denotes | RNase L | Gene:6041 |
| 1161 | 441-448 | Gene | denotes | RNase L | Gene:6041 |
| 1162 | 664-671 | Gene | denotes | RNase L | Gene:6041 |
| 1163 | 905-908 | Gene | denotes | bat | Gene:570 |
| 1164 | 45-48 | Species | denotes | CoV | Tax:11118 |
| 1165 | 687-691 | Species | denotes | CoVs | Tax:11118 |
| 1166 | 760-763 | Species | denotes | CoV | Tax:11118 |
| 1167 | 804-825 | Species | denotes | mouse hepatitis virus | Tax:11138 |
| 1168 | 869-873 | Species | denotes | CoVs | Tax:11118 |
| 1169 | 909-912 | Species | denotes | CoV | Tax:11118 |
| 1170 | 942-950 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1171 | 980-1001 | Species | denotes | mouse hepatitis virus | Tax:11138 |
| 1172 | 1096-1100 | Species | denotes | CoVs | Tax:11118 |
| 1173 | 1299-1303 | Species | denotes | CoVs | Tax:11118 |
| 1174 | 1431-1437 | Species | denotes | humans | Tax:9606 |
| 1175 | 637-645 | Disease | denotes | infected | MESH:D007239 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-26231767-27782270 | 383-385 | 26231767 | denotes | 65 |
| 32172672-26231767-27782271 | 542-544 | 26231767 | denotes | 65 |
| 32172672-27743750-27782272 | 745-747 | 27743750 | denotes | 66 |
| 32172672-27025250-27782273 | 1067-1069 | 27025250 | denotes | 67 |