PMC:7102591 / 28717-29734 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"876","span":{"begin":957,"end":966},"obj":"Species"},{"id":"877","span":{"begin":625,"end":634},"obj":"Species"},{"id":"878","span":{"begin":816,"end":827},"obj":"Chemical"},{"id":"879","span":{"begin":129,"end":138},"obj":"Disease"},{"id":"880","span":{"begin":340,"end":348},"obj":"Disease"},{"id":"881","span":{"begin":967,"end":976},"obj":"Disease"}],"attributes":[{"id":"A876","pred":"tao:has_database_id","subj":"876","obj":"Tax:2697049"},{"id":"A877","pred":"tao:has_database_id","subj":"877","obj":"Tax:11309"},{"id":"A878","pred":"tao:has_database_id","subj":"878","obj":"MESH:C000596027"},{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"MESH:D007239"},{"id":"A880","pred":"tao:has_database_id","subj":"880","obj":"MESH:D007239"},{"id":"A881","pred":"tao:has_database_id","subj":"881","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T108","span":{"begin":349,"end":354},"obj":"Body_part"}],"attributes":[{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p51685s7","span":{"begin":653,"end":671},"obj":"Pathway"},{"id":"p51685s12","span":{"begin":675,"end":683},"obj":"NegReg"},{"id":"p51685s14","span":{"begin":688,"end":698},"obj":"MPA"},{"id":"p51685s22","span":{"begin":735,"end":745},"obj":"NegReg"},{"id":"p51685s23","span":{"begin":746,"end":759},"obj":"Pathway"},{"id":"p51686s18","span":{"begin":868,"end":896},"obj":"MPA"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T304","span":{"begin":129,"end":138},"obj":"Disease"},{"id":"T305","span":{"begin":625,"end":634},"obj":"Disease"},{"id":"T306","span":{"begin":957,"end":961},"obj":"Disease"},{"id":"T307","span":{"begin":967,"end":976},"obj":"Disease"}],"attributes":[{"id":"A304","pred":"mondo_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A305","pred":"mondo_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A306","pred":"mondo_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A307","pred":"mondo_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T218","span":{"begin":150,"end":160},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T219","span":{"begin":195,"end":204},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T220","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T221","span":{"begin":325,"end":332},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T222","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T223","span":{"begin":373,"end":380},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T224","span":{"begin":475,"end":484},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T225","span":{"begin":635,"end":636},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T226","span":{"begin":637,"end":644},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T227","span":{"begin":662,"end":671},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T228","span":{"begin":750,"end":759},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T229","span":{"begin":761,"end":764},"obj":"http://purl.obolibrary.org/obo/CLO_0053001"},{"id":"T230","span":{"begin":770,"end":771},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T231","span":{"begin":903,"end":904},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T238","span":{"begin":258,"end":268},"obj":"Chemical"}],"attributes":[{"id":"A238","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T62","span":{"begin":49,"end":72},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T63","span":{"begin":84,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T64","span":{"begin":84,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T65","span":{"begin":164,"end":177},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T66","span":{"begin":190,"end":212},"obj":"http://purl.obolibrary.org/obo/GO_0097696"},{"id":"T67","span":{"begin":195,"end":212},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T68","span":{"begin":195,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T69","span":{"begin":475,"end":492},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T70","span":{"begin":475,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T71","span":{"begin":593,"end":602},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T72","span":{"begin":593,"end":602},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T73","span":{"begin":662,"end":671},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T74","span":{"begin":750,"end":759},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"LitCovid-sentences","denotations":[{"id":"T158","span":{"begin":0,"end":145},"obj":"Sentence"},{"id":"T159","span":{"begin":146,"end":361},"obj":"Sentence"},{"id":"T160","span":{"begin":362,"end":609},"obj":"Sentence"},{"id":"T161","span":{"begin":610,"end":766},"obj":"Sentence"},{"id":"T162","span":{"begin":767,"end":1017},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}

{"project":"2_test","denotations":[{"id":"32205186-18049472-4826926","span":{"begin":140,"end":143},"obj":"18049472"}],"text":"On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified."}