PMC:7102591 / 28717-29734
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 876 | 957-966 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 877 | 625-634 | Species | denotes | Influenza | Tax:11309 |
| 878 | 816-827 | Chemical | denotes | baricitinib | MESH:C000596027 |
| 879 | 129-138 | Disease | denotes | infection | MESH:D007239 |
| 880 | 340-348 | Disease | denotes | infected | MESH:D007239 |
| 881 | 967-976 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T108 | 349-354 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p51685s7 | 653-671 | Pathway | denotes | JAK/STAT signaling |
| p51685s12 | 675-683 | NegReg | denotes | reducing |
| p51685s14 | 688-698 | MPA | denotes | expression |
| p51685s22 | 735-745 | NegReg | denotes | inhibiting |
| p51685s23 | 746-759 | Pathway | denotes | IFN signaling |
| p51686s18 | 868-896 | MPA | denotes | mediated anti-viral response |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T304 | 129-138 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T305 | 625-634 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T306 | 957-961 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T307 | 967-976 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T218 | 150-160 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T219 | 195-204 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T220 | 280-285 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T221 | 325-332 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T222 | 349-354 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T223 | 373-380 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T224 | 475-484 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T225 | 635-636 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T226 | 637-644 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T227 | 662-671 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T228 | 750-759 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T229 | 761-764 | http://purl.obolibrary.org/obo/CLO_0053001 | denotes | 114 |
| T230 | 770-771 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T231 | 903-904 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T238 | 258-268 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T62 | 49-72 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune responses |
| T63 | 84-101 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T64 | 84-101 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T65 | 164-177 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T66 | 190-212 | http://purl.obolibrary.org/obo/GO_0097696 | denotes | STAT signaling pathway |
| T67 | 195-212 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T68 | 195-204 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T69 | 475-492 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T70 | 475-484 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T71 | 593-602 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
| T72 | 593-602 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
| T73 | 662-671 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T74 | 750-759 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T158 | 0-145 | Sentence | denotes | On the other side, IFN is one of the most potent innate immune responses to prevent viral replication during the early phases of infection [110]. |
| T159 | 146-361 | Sentence | denotes | The activation of transcription through JAK/STAT signaling pathway by IFNs leads to the upregulation of several interferon stimulated genes which have the ability to rapidly kill viruses within infected cells [111]. |
| T160 | 362-609 | Sentence | denotes | Almost all viruses have developed strategies to combat the effects of type 1 and type 3 IFNs by blocking the IFN signaling pathway [112] and viral encoded factors able to antagonize the JAK/STAT pathway are crucial determinants of virulence [113]. |
| T161 | 610-766 | Sentence | denotes | In particular, Influenza A viruses disrupt JAK/STAT signaling by reducing the expression of the IFN receptor and by directly inhibiting IFN signaling [114]. |
| T162 | 767-1017 | Sentence | denotes | As a consequence, JAK/STAT blockade generated by baricitinib certainly produces an impairment of IFN-mediated anti-viral response, with a potential facilitating effect on the progression of SARS-CoV2 infection at the moment not yet better quantified. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32205186-18049472-4826926 | 140-143 | 18049472 | denotes | 110 |