PMC:7102591 / 25754-26530 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"759","span":{"begin":5,"end":8},"obj":"Gene"},{"id":"764","span":{"begin":103,"end":107},"obj":"Gene"},{"id":"765","span":{"begin":161,"end":166},"obj":"Gene"},{"id":"766","span":{"begin":45,"end":63},"obj":"Disease"},{"id":"767","span":{"begin":202,"end":213},"obj":"Disease"},{"id":"778","span":{"begin":274,"end":297},"obj":"Gene"},{"id":"779","span":{"begin":299,"end":303},"obj":"Gene"},{"id":"780","span":{"begin":331,"end":335},"obj":"Gene"},{"id":"781","span":{"begin":460,"end":464},"obj":"Gene"},{"id":"782","span":{"begin":516,"end":519},"obj":"Gene"},{"id":"783","span":{"begin":565,"end":574},"obj":"Species"},{"id":"784","span":{"begin":656,"end":666},"obj":"Chemical"},{"id":"785","span":{"begin":575,"end":584},"obj":"Disease"},{"id":"786","span":{"begin":670,"end":678},"obj":"Disease"},{"id":"787","span":{"begin":679,"end":688},"obj":"Disease"}],"attributes":[{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"Gene:7124"},{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"Gene:59272"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"Gene:5972"},{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"MESH:C000657245"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"MESH:D055370"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"Gene:6868"},{"id":"A779","pred":"tao:has_database_id","subj":"779","obj":"Gene:6868"},{"id":"A780","pred":"tao:has_database_id","subj":"780","obj":"Gene:59272"},{"id":"A781","pred":"tao:has_database_id","subj":"781","obj":"Gene:7124"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"Gene:7124"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"Tax:2697049"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"MESH:D000068879"},{"id":"A785","pred":"tao:has_database_id","subj":"785","obj":"MESH:D007239"},{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"MESH:C000657245"},{"id":"A787","pred":"tao:has_database_id","subj":"787","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T96","span":{"begin":202,"end":206},"obj":"Body_part"},{"id":"T97","span":{"begin":246,"end":253},"obj":"Body_part"},{"id":"T98","span":{"begin":398,"end":402},"obj":"Body_part"},{"id":"T99","span":{"begin":604,"end":609},"obj":"Body_part"}],"attributes":[{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma67498"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T25","span":{"begin":161,"end":185},"obj":"Body_part"},{"id":"T26","span":{"begin":202,"end":206},"obj":"Body_part"},{"id":"T27","span":{"begin":604,"end":609},"obj":"Body_part"}],"attributes":[{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p51664s14","span":{"begin":83,"end":97},"obj":"NegReg"},{"id":"p51664s17","span":{"begin":103,"end":113},"obj":"MPA"},{"id":"p51664s21","span":{"begin":132,"end":141},"obj":"PosReg"},{"id":"p51664s22","span":{"begin":135,"end":143},"obj":"MPA"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T283","span":{"begin":45,"end":63},"obj":"Disease"},{"id":"T284","span":{"begin":54,"end":63},"obj":"Disease"},{"id":"T285","span":{"begin":207,"end":213},"obj":"Disease"},{"id":"T286","span":{"begin":565,"end":569},"obj":"Disease"},{"id":"T287","span":{"begin":575,"end":584},"obj":"Disease"},{"id":"T288","span":{"begin":670,"end":678},"obj":"Disease"},{"id":"T289","span":{"begin":679,"end":688},"obj":"Disease"}],"attributes":[{"id":"A283","pred":"mondo_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A284","pred":"mondo_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A285","pred":"mondo_id","subj":"T285","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A286","pred":"mondo_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A287","pred":"mondo_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A288","pred":"mondo_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A289","pred":"mondo_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T188","span":{"begin":83,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T189","span":{"begin":145,"end":153},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T190","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T191","span":{"begin":202,"end":206},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T192","span":{"begin":272,"end":273},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T193","span":{"begin":383,"end":388},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T194","span":{"begin":398,"end":402},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T195","span":{"begin":480,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T196","span":{"begin":604,"end":609},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T197","span":{"begin":627,"end":628},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T198","span":{"begin":637,"end":638},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T199","span":{"begin":689,"end":692},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T208","span":{"begin":9,"end":19},"obj":"Chemical"},{"id":"T209","span":{"begin":167,"end":178},"obj":"Chemical"},{"id":"T210","span":{"begin":246,"end":253},"obj":"Chemical"},{"id":"T211","span":{"begin":520,"end":530},"obj":"Chemical"}],"attributes":[{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A211","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T141","span":{"begin":0,"end":19},"obj":"Sentence"},{"id":"T142","span":{"begin":20,"end":219},"obj":"Sentence"},{"id":"T143","span":{"begin":220,"end":408},"obj":"Sentence"},{"id":"T144","span":{"begin":409,"end":623},"obj":"Sentence"},{"id":"T145","span":{"begin":624,"end":776},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}

{"project":"2_test","denotations":[{"id":"32205186-24800825-4826919","span":{"begin":215,"end":217},"obj":"24800825"},{"id":"32205186-18490652-4826920","span":{"begin":404,"end":406},"obj":"18490652"},{"id":"32205186-17532082-4826921","span":{"begin":618,"end":621},"obj":"17532082"}],"text":"5.3 TNF inhibitors\nAs previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14].\nMoreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089)."}