PMC:7102591 / 25754-26530
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 759 | 5-8 | Gene | denotes | TNF | Gene:7124 |
| 764 | 103-107 | Gene | denotes | ACE2 | Gene:59272 |
| 765 | 161-166 | Gene | denotes | renin | Gene:5972 |
| 766 | 45-63 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 767 | 202-213 | Disease | denotes | lung injury | MESH:D055370 |
| 778 | 274-297 | Gene | denotes | TNF-α-converting enzyme | Gene:6868 |
| 779 | 299-303 | Gene | denotes | TACE | Gene:6868 |
| 780 | 331-335 | Gene | denotes | ACE2 | Gene:59272 |
| 781 | 460-464 | Gene | denotes | TNFα | Gene:7124 |
| 782 | 516-519 | Gene | denotes | TNF | Gene:7124 |
| 783 | 565-574 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 784 | 656-666 | Chemical | denotes | adalimumab | MESH:D000068879 |
| 785 | 575-584 | Disease | denotes | infection | MESH:D007239 |
| 786 | 670-678 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 787 | 679-688 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T96 | 202-206 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T97 | 246-253 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T98 | 398-402 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T99 | 604-609 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T25 | 161-185 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T26 | 202-206 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T27 | 604-609 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p51664s14 | 83-97 | NegReg | denotes | a downregulati |
| p51664s17 | 103-113 | MPA | denotes | ACE2 expre |
| p51664s21 | 132-141 | PosReg | denotes | an increa |
| p51664s22 | 135-143 | MPA | denotes | increase |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T283 | 45-63 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T284 | 54-63 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T285 | 207-213 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T286 | 565-569 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T287 | 575-584 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T288 | 670-678 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T289 | 679-688 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T188 | 83-84 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T189 | 145-153 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T190 | 202-206 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T191 | 202-206 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T192 | 272-273 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T193 | 383-388 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T194 | 398-402 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T195 | 480-483 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T196 | 604-609 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T197 | 627-628 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T198 | 637-638 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T199 | 689-692 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T208 | 9-19 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T209 | 167-178 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T210 | 246-253 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T211 | 520-530 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T141 | 0-19 | Sentence | denotes | 5.3 TNF inhibitors |
| T142 | 20-219 | Sentence | denotes | As previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14]. |
| T143 | 220-408 | Sentence | denotes | Moreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. |
| T144 | 409-623 | Sentence | denotes | Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. |
| T145 | 624-776 | Sentence | denotes | As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32205186-24800825-4826919 | 215-217 | 24800825 | denotes | 14 |
| 32205186-18490652-4826920 | 404-406 | 18490652 | denotes | 99 |
| 32205186-17532082-4826921 | 618-621 | 17532082 | denotes | 100 |