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PMC:7102591 / 21823-23181 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
657 235-240 Gene denotes ACE 2 Gene:59272
658 738-746 Species denotes patients Tax:9606
659 40-51 Chemical denotes chloroquine MESH:D002738
660 459-470 Chemical denotes chloroquine MESH:D002738
661 770-781 Chemical denotes chloroquine MESH:D002738
662 1023-1041 Chemical denotes hydroxychloroquine MESH:D006886
663 1095-1106 Chemical denotes chloroquine MESH:D002738
664 421-439 Disease denotes SARS CoV infection MESH:C000657245
665 610-618 Disease denotes COVID-19 MESH:C000657245
666 886-895 Disease denotes pneumonia MESH:D011014
667 1332-1352 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T77 76-85 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T78 108-112 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T79 832-836 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 832-836 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51644s32 187-209 MPA denotes terminal glycosylation
p51645s8 315-332 MPA denotes -receptor binding

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T248 421-425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 430-439 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T250 610-618 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T251 886-895 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T252 1332-1340 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 1343-1352 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T146 102-107 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 108-112 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T148 155-163 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T149 310-315 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T150 347-348 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T151 444-445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 471-474 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T153 582-588 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T154 832-836 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T155 832-836 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T156 907-908 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T157 909-914 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T158 1224-1225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T177 40-51 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T178 373-377 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T179 459-470 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T180 675-680 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T181 770-781 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T182 1023-1041 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T183 1095-1106 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T41 108-119 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T42 108-119 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T43 108-119 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T44 108-119 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T45 146-163 http://purl.obolibrary.org/obo/GO_0038024 denotes receptor activity
T46 187-209 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T47 196-209 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T123 0-260 Sentence denotes At clinically admissible concentrations chloroquine is able to increase the endosomal pH required for virus/cell fusion, to inhibit the toll-like receptor activity, and to interfere with terminal glycosylation of the cellular receptor ACE 2 [[88], [89], [90]].
T124 261-440 Sentence denotes All these functions may negatively influence the virus-receptor binding, resulting in a potential effect of the drug on both entry and post-entry stages of the SARS CoV infection.
T125 441-702 Sentence denotes As a consequence, chloroquine has recently been included in at least 10 randomized controlled trials currently ongoing in China, where it is tested for the treatment of COVID-19 under various combination protocols with the anti-viral drugs mentioned above [91].
T126 703-1007 Sentence denotes Interim results from more than 100 patients have demonstrated that chloroquine is superior to the control treatment in improving lung imaging findings, inhibiting the exacerbation of pneumonia, promoting a virus negative conversion, and shortening the disease course at different levels of severity [92].
T127 1008-1167 Sentence denotes More recently, hydroxychloroquine was demonstrated to be more 3-times more potent than chloroquine in an in vitro study based on pharmacokinetic models (PBPK).
T128 1168-1358 Sentence denotes An oral loading dose of 400 mg twice daily, followed by a maintenance dose of 200 mg given twice daily for 4 days seems to be the best option for the management of SARS-CoV-2 infection [93].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T73 886-895 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32205186-16115318-4826916 243-245 16115318 denotes 88
32205186-16439323-4826917 255-257 16439323 denotes 90