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PMC:7102583 / 15464-16871 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
649 399-403 Gene denotes IL-6 Gene:3569
650 405-410 Gene denotes TNF-α Gene:7124
651 682-687 Gene denotes TNF-α Gene:7124
652 689-693 Gene denotes IL-6 Gene:3569
653 695-700 Gene denotes IL-1β Gene:3552
654 1161-1166 Gene denotes TNF-α Gene:7124
655 1171-1175 Gene denotes IL-6 Gene:3569
656 82-90 Species denotes patients Tax:9606
657 449-457 Species denotes patients Tax:9606
658 525-533 Species denotes patients Tax:9606
659 1398-1406 Species denotes patients Tax:9606
660 60-69 Chemical denotes melatonin MESH:D008550
661 183-192 Chemical denotes melatonin MESH:D008550
662 340-349 Chemical denotes melatonin MESH:D008550
663 594-603 Chemical denotes melatonin MESH:D008550
664 705-718 Chemical denotes lipoperoxides MESH:D008054
665 862-871 Chemical denotes melatonin MESH:D008550
666 912-921 Chemical denotes melatonin MESH:D008550
667 1105-1114 Chemical denotes melatonin MESH:D008550
668 1236-1245 Chemical denotes melatonin MESH:D008550
669 73-81 Disease denotes COVID-19 MESH:C000657245
670 150-162 Disease denotes inflammation MESH:D007249
671 463-480 Disease denotes diabetes mellitus MESH:D003920
672 485-498 Disease denotes periodontitis MESH:D010518
673 556-574 Disease denotes multiple sclerosis MESH:D009103
674 747-759 Disease denotes inflammation MESH:D007249
675 1389-1397 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T166 60-69 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T167 183-192 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T168 259-268 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T169 340-349 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T170 383-388 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T171 429-436 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 594-603 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T173 658-663 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T174 695-699 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T175 800-805 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T176 828-843 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T177 862-871 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T178 912-921 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T179 987-996 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T180 1105-1114 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T181 1236-1245 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T182 1311-1320 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T183 1370-1378 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T38 383-388 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T39 658-663 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T40 800-805 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 828-843 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T42 837-843 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51335s20 359-367 NegReg denotes signific
p51336s25 631-640 NegReg denotes a signifi
p51341s25 1347-1352 NegReg denotes lower
p51341s26 1353-1385 MPA denotes pro-inflammatory cytokine levels

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T170 73-81 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 150-162 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T172 463-480 Disease denotes diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005015
T173 485-498 Disease denotes periodontitis http://purl.obolibrary.org/obo/MONDO_0005076
T174 556-574 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301
T175 747-759 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T176 1389-1397 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T208 280-281 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 357-358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 415-419 http://purl.obolibrary.org/obo/CL_0000037 denotes hs-C
T211 631-632 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 800-805 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T213 800-805 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T214 837-843 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T215 837-843 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T216 951-952 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 998-999 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T218 1024-1025 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 1035-1037 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T220 1082-1083 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T221 1134-1135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 1249-1250 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T154 60-69 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T155 168-179 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T156 183-192 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T157 340-349 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T158 399-401 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T160 429-436 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 594-603 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T162 689-691 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T164 695-697 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T166 862-871 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T167 912-921 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T168 1105-1114 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T169 1171-1173 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T171 1236-1245 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T72 150-162 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T73 747-759 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T107 0-276 Sentence denotes Although there is obviously no report related to the use of melatonin in COVID-19 patients, in subjects with other diseases and an increased level of inflammation, the application of melatonin showed promising results regarding the attenuation of circulating cytokines levels.
T108 277-504 Sentence denotes In a randomized controlled trial, 8-week oral intake of 6 mg/d melatonin caused a significant decrease in serum levels of IL-6, TNF-α and hs-C-reactive protein (hs-CRP) in patients with diabetes mellitus and periodontitis [56].
T109 505-724 Sentence denotes In another trial of patients suffering with severe multiple sclerosis, orally 25 mg/d of melatonin for 6 months also promoted a significant reduction in serum concentrations of TNF-α, IL-6, IL-1β and lipoperoxides [57].
T110 725-997 Sentence denotes In the acute phase of inflammation, including during surgical stress [58], brain reperfusion [59], and coronary artery reperfusion [60], melatonin intake of 10 mg/d, 6 mg/d and 5 mg/d of melatonin for less than 5 days induced a reduced level of pro-inflammatory cytokines.
T111 998-1187 Sentence denotes A recent meta-analysis of a total of 22 randomized controlled trials suggested that a supplementary use of melatonin is associated with a significant reduction of TNF-α and IL-6 level [61].
T112 1188-1407 Sentence denotes This clinical evidence suggests that the use of melatonin as a supplement may effectively reduce the levels of circulating cytokines, and may potentially also lower pro-inflammatory cytokine levels in COVID-19 patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T75 463-480 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T76 485-498 Phenotype denotes periodontitis http://purl.obolibrary.org/obo/HP_0000704

2_test

Id Subject Object Predicate Lexical cue
32217117-30328031-66453514 500-502 30328031 denotes 56
32217117-30595364-66453515 720-722 30595364 denotes 57
32217117-18205732-66453516 795-797 18205732 denotes 58
32217117-30098076-66453517 819-821 30098076 denotes 59
32217117-30045259-66453518 857-859 30045259 denotes 60