PMC:7102560 / 5680-7650 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7102560","sourcedb":"PMC","sourceid":"7102560","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7102560","text":"Four of the 5 patients presented with a fever without chills, one had a high fever (39.3 °C). Patients’ body temperatures fluctuated within a range from 36.2 to 39.3 °C. One patient showed normal body temperature. Other symptoms of an upper respiratory tract infection were also observed: one patient had cough, one had sore throat, all patients reported fatigue (Table 1 ). Additionally, one patient showed constipation. However, none of the 5 patients developed severe pneumonia, requiring mechanical ventilation, or died of COVID-19 pneumonia, as of Feb. 24, 2020.\nTable 1 Clinical and laboratory characteristics.\nClinical characteristics Patient 1 Patient 2 Patient 3 Patient 4 Patient 5\nDate of admission Jan. 3 Jan. 13 Jan. 27 Jan. 22 Jan. 20\nSex Male Male Female Female Female\nAge (years) 30 42 32 27 31\nEpidemiological history Yes Yes Yes Yes Yes\nSARS-CoV-2 negative to positive (days) 4 8 17 15 9\nComplications None None None None None\nSigns and symptoms\nFever on admission Yes Yes Yes No Yes\nCough No Yes No No No\nDyspnoea No No No No No\nSore throat No No Yes No No\nFatigue Yes Yes Yes Yes Yes\nLaboratory characteristics\nWhite blood cell count (× 109 cells per L) 5.9 7.1 4.4 6.5 4.5\nNeutrophil count (× 109 cells per L) 3.5 4.5 1.8 4.1 2.6\nLymphocyte count (× 109 cells per L) 1.7 1.3 1.7 1.7 1.4\nMonocyte count (× 109 cells per L) 0.63 1.24 0.75 0.58 0.4\nEosinophil count (× 109 cells per L) 0.13 0.05 0.02 0.09 0\nBasophile count (× 109 cells per L) 0.02 0.04 0.03 0.02 0.02\nC-reactive protein (mg/L) 18.7 23.7 NA \u003c0.50 NA\nElevated ALT (\u003e45 U/L) or AST (\u003e35 U/L) No No No No No\nALT (U/L) 40 16 11 9 10\nAST(U/L) 32 19 20 13 22\nConfirmatory test (SARS-CoV-2 PCR) Yes Yes Yes Yes Yes\nCT evidence of pneumonia\nTypical signs of viral infection Yes Yes Yes Yes Yes\nTreatment\nAntiviral therapy Yes Yes Yes Yes Yes\nAntibiotic therapy Yes Yes Yes Yes Yes\nUse of corticosteroid Yes Yes No No Yes\nNA=not applicable. 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