PMC:7100515 / 32651-33151 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T276","span":{"begin":36,"end":49},"obj":"Body_part"},{"id":"T277","span":{"begin":189,"end":197},"obj":"Body_part"},{"id":"T278","span":{"begin":386,"end":393},"obj":"Body_part"}],"attributes":[{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma67467"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T312","span":{"begin":373,"end":381},"obj":"Disease"},{"id":"T313","span":{"begin":490,"end":499},"obj":"Disease"}],"attributes":[{"id":"A312","pred":"mondo_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A313","pred":"mondo_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T720","span":{"begin":84,"end":86},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T721","span":{"begin":150,"end":152},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T722","span":{"begin":164,"end":165},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T723","span":{"begin":189,"end":197},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T724","span":{"begin":221,"end":226},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T725","span":{"begin":418,"end":420},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T241","span":{"begin":77,"end":79},"obj":"Chemical"},{"id":"T245","span":{"begin":84,"end":86},"obj":"Chemical"},{"id":"T246","span":{"begin":143,"end":145},"obj":"Chemical"},{"id":"T250","span":{"begin":150,"end":152},"obj":"Chemical"},{"id":"T251","span":{"begin":177,"end":185},"obj":"Chemical"},{"id":"T252","span":{"begin":386,"end":393},"obj":"Chemical"},{"id":"T253","span":{"begin":411,"end":413},"obj":"Chemical"},{"id":"T257","span":{"begin":418,"end":420},"obj":"Chemical"},{"id":"T258","span":{"begin":470,"end":474},"obj":"Chemical"}],"attributes":[{"id":"A241","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A242","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A243","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A244","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A245","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A247","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A248","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A249","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A254","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A255","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A256","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T242","span":{"begin":0,"end":247},"obj":"Sentence"},{"id":"T243","span":{"begin":248,"end":500},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"2_test","denotations":[{"id":"32221306-30121440-73894046","span":{"begin":244,"end":246},"obj":"30121440"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1365","span":{"begin":158,"end":162},"obj":"Gene"},{"id":"1366","span":{"begin":326,"end":330},"obj":"Gene"},{"id":"1367","span":{"begin":143,"end":152},"obj":"Gene"},{"id":"1368","span":{"begin":384,"end":385},"obj":"Gene"},{"id":"1369","span":{"begin":411,"end":420},"obj":"Gene"},{"id":"1370","span":{"begin":77,"end":86},"obj":"Gene"},{"id":"1371","span":{"begin":236,"end":244},"obj":"Species"},{"id":"1372","span":{"begin":373,"end":383},"obj":"Species"},{"id":"1373","span":{"begin":486,"end":499},"obj":"Disease"}],"attributes":[{"id":"A1365","pred":"tao:has_database_id","subj":"1365","obj":"Gene:219931"},{"id":"A1366","pred":"tao:has_database_id","subj":"1366","obj":"Gene:219931"},{"id":"A1367","pred":"tao:has_database_id","subj":"1367","obj":"Gene:5266"},{"id":"A1368","pred":"tao:has_database_id","subj":"1368","obj":"Gene:43740568"},{"id":"A1369","pred":"tao:has_database_id","subj":"1369","obj":"Gene:5266"},{"id":"A1370","pred":"tao:has_database_id","subj":"1370","obj":"Gene:5266"},{"id":"A1371","pred":"tao:has_database_id","subj":"1371","obj":"Tax:1335626"},{"id":"A1372","pred":"tao:has_database_id","subj":"1372","obj":"Tax:2697049"},{"id":"A1373","pred":"tao:has_database_id","subj":"1373","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection."}