PMC:7100515 / 32651-33151
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T276 | 36-49 | Body_part | denotes | late endosome | http://purl.org/sig/ont/fma/fma67467 |
| T277 | 189-197 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T278 | 386-393 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T312 | 373-381 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T313 | 490-499 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T720 | 84-86 | http://purl.obolibrary.org/obo/CLO_0008307 | denotes | P2 |
| T721 | 150-152 | http://purl.obolibrary.org/obo/CLO_0008307 | denotes | P2 |
| T722 | 164-165 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T723 | 189-197 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T724 | 221-226 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T725 | 418-420 | http://purl.obolibrary.org/obo/CLO_0008307 | denotes | P2 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T241 | 77-79 | Chemical | denotes | PI | http://purl.obolibrary.org/obo/CHEBI_28874|http://purl.obolibrary.org/obo/CHEBI_53806|http://purl.obolibrary.org/obo/CHEBI_61484|http://purl.obolibrary.org/obo/CHEBI_74790 |
| T245 | 84-86 | Chemical | denotes | P2 | http://purl.obolibrary.org/obo/CHEBI_33472 |
| T246 | 143-145 | Chemical | denotes | PI | http://purl.obolibrary.org/obo/CHEBI_28874|http://purl.obolibrary.org/obo/CHEBI_53806|http://purl.obolibrary.org/obo/CHEBI_61484|http://purl.obolibrary.org/obo/CHEBI_74790 |
| T250 | 150-152 | Chemical | denotes | P2 | http://purl.obolibrary.org/obo/CHEBI_33472 |
| T251 | 177-185 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T252 | 386-393 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T253 | 411-413 | Chemical | denotes | PI | http://purl.obolibrary.org/obo/CHEBI_28874|http://purl.obolibrary.org/obo/CHEBI_53806|http://purl.obolibrary.org/obo/CHEBI_61484|http://purl.obolibrary.org/obo/CHEBI_74790 |
| T257 | 418-420 | Chemical | denotes | P2 | http://purl.obolibrary.org/obo/CHEBI_33472 |
| T258 | 470-474 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T242 | 0-247 | Sentence | denotes | Recent studies showed that early to late endosome maturation is regulated by PI(3,5)P2, and inhibition of PIKfyve, the key enzyme synthesizing PI(3,5)P2, and TPC2, a downstream effector in lysosome, significantly reduced virus entry of MERS-CoV52. |
| T243 | 248-500 | Sentence | denotes | We confirmed this in this study, and further showed that blocking PIKfyve and TPC2 also strongly inhibited entry mediated by SARS-CoV-2 S protein, indicating that PI(3,5)P2 pathway might be considered as potential general drug target for CoV infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32221306-30121440-73894046 | 244-246 | 30121440 | denotes | 52 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1365 | 158-162 | Gene | denotes | TPC2 | Gene:219931 |
| 1366 | 326-330 | Gene | denotes | TPC2 | Gene:219931 |
| 1367 | 143-152 | Gene | denotes | PI(3,5)P2 | Gene:5266 |
| 1368 | 384-385 | Gene | denotes | S | Gene:43740568 |
| 1369 | 411-420 | Gene | denotes | PI(3,5)P2 | Gene:5266 |
| 1370 | 77-86 | Gene | denotes | PI(3,5)P2 | Gene:5266 |
| 1371 | 236-244 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1372 | 373-383 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1373 | 486-499 | Disease | denotes | CoV infection | MESH:D018352 |