PMC:7100515 / 26860-29045 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7100515","sourcedb":"PMC","sourceid":"7100515","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7100515","text":"As rabbit polyclonal anti-SARS S1 antibodies did not show significant neutralization activity against SARS-CoV-2 S pseudovirions, we then asked whether sera from recovered SARS and COVID-19 patients could neutralize SARS-CoV S and SARS-CoV-2 S pseudovirions. We obtained sera from one recovered SARS patient and five recovered COVID-19 patients and tested their neutralization activities against transduction on 293/hACE2 cells by SARS-CoV and SARS-CoV-2 S pseudovirions. Serum from recovered SARS patient showed strong inhibition on transduction by SARS-CoV S pseudovirions, and it had modest neutralization activity against SARS-CoV-2 S pseudovirons (Fig. 6a and Table 1). In contrast, sera from all five COVID-19 patients neutralized SARS-CoV-2 S pseudovirions effectively, and none of them had an effect on transduction by SARS-CoV S pseudovirions (Fig. 6b and Table 1).\nFig. 6 Limited cross-neutralization of SARS and COVID-19 sera.\nAll sera were incubated on 56 °C for 30 min to eliminate complement. SARS-CoV S and SARS-CoV-2 S pseudovirons were pre-incubated with serially diluted SARS patient serum (a) or COVID-19 patient sera (b) for 1 h on ice and then added on 293/hACE2 cells. Pseudoviral transduction was measured 40 h later. Experiments were done in triplicates and repeated twice, and one representative is shown. Error bars indicate SEM of technical triplicates. Source data are provided as a Source Data file.\nTable 1 Neutralization activities of antisera from SARS-CoV and COVID-19 patients.\nPatient serum SARS-CoV S pseudovirion SARS-CoV-2 S pseudovirion\nSARS-CoV patient \u003e80 40\nCOVID-19 patient #1 Not detected \u003e80\nCOVID-19 patient #2 Not detected 40\nCOVID-19 patient #3 Not detected \u003e80\nCOVID-19 patient #4 Not detected \u003e80\nCOVID-19 patient #5 Not detected \u003e80\nSARS-CoV and SARS-CoV-2 S pseudovirions were pre-incubated with serially diluted patient sera for 1 h on ice, then virus-antibody mixture was added on 293/hACE2 cells. Cells were lysed 40 h later and pseudovirus transduction was measured. The highest dilution of the serum sample that decreased transduction by 50% or more was considered to be positive. Source data are provided as a Source Data file.","divisions":[{"label":"figure","span":{"begin":875,"end":1428}},{"label":"label","span":{"begin":875,"end":881}},{"label":"caption","span":{"begin":882,"end":1428}},{"label":"title","span":{"begin":882,"end":937}},{"label":"p","span":{"begin":938,"end":1428}},{"label":"label","span":{"begin":1429,"end":1436}},{"label":"caption","span":{"begin":1437,"end":1511}},{"label":"p","span":{"begin":1437,"end":1511}},{"label":"table","span":{"begin":1512,"end":1783}},{"label":"tr","span":{"begin":1512,"end":1575}},{"label":"th","span":{"begin":1512,"end":1525}},{"label":"th","span":{"begin":1526,"end":1549}},{"label":"th","span":{"begin":1550,"end":1575}},{"label":"tr","span":{"begin":1576,"end":1599}},{"label":"td","span":{"begin":1576,"end":1592}},{"label":"td","span":{"begin":1593,"end":1596}},{"label":"td","span":{"begin":1597,"end":1599}},{"label":"tr","span":{"begin":1600,"end":1636}},{"label":"td","span":{"begin":1600,"end":1619}},{"label":"td","span":{"begin":1620,"end":1632}},{"label":"td","span":{"begin":1633,"end":1636}},{"label":"tr","span":{"begin":1637,"end":1672}},{"label":"td","span":{"begin":1637,"end":1656}},{"label":"td","span":{"begin":1657,"end":1669}},{"label":"td","span":{"begin":1670,"end":1672}},{"label":"tr","span":{"begin":1673,"end":1709}},{"label":"td","span":{"begin":1673,"end":1692}},{"label":"td","span":{"begin":1693,"end":1705}},{"label":"td","span":{"begin":1706,"end":1709}},{"label":"tr","span":{"begin":1710,"end":1746}},{"label":"td","span":{"begin":1710,"end":1729}},{"label":"td","span":{"begin":1730,"end":1742}},{"label":"td","span":{"begin":1743,"end":1746}},{"label":"tr","span":{"begin":1747,"end":1783}},{"label":"td","span":{"begin":1747,"end":1766}},{"label":"td","span":{"begin":1767,"end":1779}},{"label":"td","span":{"begin":1780,"end":1783}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T234","span":{"begin":422,"end":427},"obj":"Body_part"},{"id":"T235","span":{"begin":472,"end":477},"obj":"Body_part"},{"id":"T236","span":{"begin":1102,"end":1107},"obj":"Body_part"},{"id":"T237","span":{"begin":1184,"end":1189},"obj":"Body_part"},{"id":"T238","span":{"begin":1520,"end":1525},"obj":"Body_part"},{"id":"T239","span":{"begin":1905,"end":1913},"obj":"Body_part"},{"id":"T240","span":{"begin":1945,"end":1950},"obj":"Body_part"},{"id":"T241","span":{"begin":1952,"end":1957},"obj":"Body_part"},{"id":"T242","span":{"begin":2051,"end":2056},"obj":"Body_part"}],"attributes":[{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma63083"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":472,"end":477},"obj":"Body_part"},{"id":"T7","span":{"begin":1102,"end":1107},"obj":"Body_part"},{"id":"T8","span":{"begin":1520,"end":1525},"obj":"Body_part"},{"id":"T9","span":{"begin":2051,"end":2056},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T247","span":{"begin":26,"end":30},"obj":"Disease"},{"id":"T248","span":{"begin":102,"end":110},"obj":"Disease"},{"id":"T249","span":{"begin":172,"end":176},"obj":"Disease"},{"id":"T250","span":{"begin":181,"end":189},"obj":"Disease"},{"id":"T251","span":{"begin":216,"end":224},"obj":"Disease"},{"id":"T252","span":{"begin":231,"end":239},"obj":"Disease"},{"id":"T253","span":{"begin":295,"end":299},"obj":"Disease"},{"id":"T254","span":{"begin":327,"end":335},"obj":"Disease"},{"id":"T255","span":{"begin":431,"end":439},"obj":"Disease"},{"id":"T256","span":{"begin":444,"end":452},"obj":"Disease"},{"id":"T257","span":{"begin":493,"end":497},"obj":"Disease"},{"id":"T258","span":{"begin":550,"end":558},"obj":"Disease"},{"id":"T259","span":{"begin":626,"end":634},"obj":"Disease"},{"id":"T260","span":{"begin":707,"end":715},"obj":"Disease"},{"id":"T261","span":{"begin":737,"end":745},"obj":"Disease"},{"id":"T262","span":{"begin":827,"end":835},"obj":"Disease"},{"id":"T263","span":{"begin":914,"end":918},"obj":"Disease"},{"id":"T264","span":{"begin":923,"end":931},"obj":"Disease"},{"id":"T265","span":{"begin":1007,"end":1015},"obj":"Disease"},{"id":"T266","span":{"begin":1022,"end":1030},"obj":"Disease"},{"id":"T267","span":{"begin":1089,"end":1093},"obj":"Disease"},{"id":"T268","span":{"begin":1115,"end":1123},"obj":"Disease"},{"id":"T269","span":{"begin":1480,"end":1488},"obj":"Disease"},{"id":"T270","span":{"begin":1493,"end":1501},"obj":"Disease"},{"id":"T271","span":{"begin":1526,"end":1534},"obj":"Disease"},{"id":"T272","span":{"begin":1550,"end":1558},"obj":"Disease"},{"id":"T273","span":{"begin":1576,"end":1584},"obj":"Disease"},{"id":"T274","span":{"begin":1600,"end":1608},"obj":"Disease"},{"id":"T275","span":{"begin":1637,"end":1645},"obj":"Disease"},{"id":"T276","span":{"begin":1673,"end":1681},"obj":"Disease"},{"id":"T277","span":{"begin":1710,"end":1718},"obj":"Disease"},{"id":"T278","span":{"begin":1747,"end":1755},"obj":"Disease"},{"id":"T279","span":{"begin":1784,"end":1792},"obj":"Disease"},{"id":"T280","span":{"begin":1797,"end":1805},"obj":"Disease"}],"attributes":[{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A249","pred":"mondo_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A250","pred":"mondo_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A252","pred":"mondo_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A255","pred":"mondo_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A256","pred":"mondo_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A257","pred":"mondo_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A258","pred":"mondo_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A259","pred":"mondo_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A260","pred":"mondo_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A261","pred":"mondo_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A262","pred":"mondo_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A263","pred":"mondo_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A264","pred":"mondo_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A265","pred":"mondo_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A266","pred":"mondo_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A267","pred":"mondo_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A268","pred":"mondo_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A269","pred":"mondo_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A270","pred":"mondo_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A271","pred":"mondo_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A272","pred":"mondo_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A273","pred":"mondo_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A274","pred":"mondo_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A275","pred":"mondo_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A276","pred":"mondo_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A277","pred":"mondo_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A278","pred":"mondo_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A279","pred":"mondo_id","subj":"T279","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A280","pred":"mondo_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T610","span":{"begin":31,"end":33},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T611","span":{"begin":85,"end":93},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T612","span":{"begin":349,"end":355},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T613","span":{"begin":377,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T614","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T615","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T616","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T617","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T618","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T619","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T620","span":{"begin":412,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T621","span":{"begin":422,"end":427},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T622","span":{"begin":609,"end":617},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T623","span":{"begin":1109,"end":1110},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T624","span":{"begin":1138,"end":1139},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T625","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T626","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T627","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T628","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T629","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T630","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T631","span":{"begin":1174,"end":1177},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T632","span":{"begin":1184,"end":1189},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T633","span":{"begin":1409,"end":1410},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T634","span":{"begin":1452,"end":1462},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T635","span":{"begin":1899,"end":1904},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T636","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T637","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T638","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T639","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T640","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T641","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T642","span":{"begin":1935,"end":1938},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T643","span":{"begin":1945,"end":1950},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T644","span":{"begin":1952,"end":1957},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T645","span":{"begin":2166,"end":2167},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T610","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T611","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T612","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T613","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T614","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T615","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T616","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T617","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T618","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T619","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T620","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T621","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T622","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T623","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T624","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T625","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T626","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T627","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T628","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T629","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T630","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T631","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T632","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T633","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T634","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T635","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T636","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T638","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T639","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T640","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T641","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T642","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T643","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T644","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T645","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T217","span":{"begin":1914,"end":1921},"obj":"Chemical"}],"attributes":[{"id":"A217","pred":"chebi_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/CHEBI_60004"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T48","span":{"begin":396,"end":408},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T49","span":{"begin":534,"end":546},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T50","span":{"begin":811,"end":823},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T51","span":{"begin":1203,"end":1215},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T52","span":{"begin":1996,"end":2008},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T53","span":{"begin":2079,"end":2091},"obj":"http://purl.obolibrary.org/obo/GO_0009293"}],"attributes":[{"subj":"T48","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T193","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"T194","span":{"begin":259,"end":471},"obj":"Sentence"},{"id":"T195","span":{"begin":472,"end":674},"obj":"Sentence"},{"id":"T196","span":{"begin":675,"end":874},"obj":"Sentence"},{"id":"T197","span":{"begin":875,"end":937},"obj":"Sentence"},{"id":"T198","span":{"begin":938,"end":1006},"obj":"Sentence"},{"id":"T199","span":{"begin":1007,"end":1190},"obj":"Sentence"},{"id":"T200","span":{"begin":1191,"end":1240},"obj":"Sentence"},{"id":"T201","span":{"begin":1241,"end":1330},"obj":"Sentence"},{"id":"T202","span":{"begin":1331,"end":1380},"obj":"Sentence"},{"id":"T203","span":{"begin":1381,"end":1428},"obj":"Sentence"},{"id":"T204","span":{"begin":1429,"end":1511},"obj":"Sentence"},{"id":"T205","span":{"begin":1512,"end":1575},"obj":"Sentence"},{"id":"T206","span":{"begin":1576,"end":1599},"obj":"Sentence"},{"id":"T207","span":{"begin":1600,"end":1636},"obj":"Sentence"},{"id":"T208","span":{"begin":1637,"end":1672},"obj":"Sentence"},{"id":"T209","span":{"begin":1673,"end":1709},"obj":"Sentence"},{"id":"T210","span":{"begin":1710,"end":1746},"obj":"Sentence"},{"id":"T211","span":{"begin":1747,"end":1783},"obj":"Sentence"},{"id":"T212","span":{"begin":1784,"end":1951},"obj":"Sentence"},{"id":"T213","span":{"begin":1952,"end":2022},"obj":"Sentence"},{"id":"T214","span":{"begin":2023,"end":2137},"obj":"Sentence"},{"id":"T215","span":{"begin":2138,"end":2185},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T193","pred":"source","obj":"LitCovid-sentences"},{"subj":"T194","pred":"source","obj":"LitCovid-sentences"},{"subj":"T195","pred":"source","obj":"LitCovid-sentences"},{"subj":"T196","pred":"source","obj":"LitCovid-sentences"},{"subj":"T197","pred":"source","obj":"LitCovid-sentences"},{"subj":"T198","pred":"source","obj":"LitCovid-sentences"},{"subj":"T199","pred":"source","obj":"LitCovid-sentences"},{"subj":"T200","pred":"source","obj":"LitCovid-sentences"},{"subj":"T201","pred":"source","obj":"LitCovid-sentences"},{"subj":"T202","pred":"source","obj":"LitCovid-sentences"},{"subj":"T203","pred":"source","obj":"LitCovid-sentences"},{"subj":"T204","pred":"source","obj":"LitCovid-sentences"},{"subj":"T205","pred":"source","obj":"LitCovid-sentences"},{"subj":"T206","pred":"source","obj":"LitCovid-sentences"},{"subj":"T207","pred":"source","obj":"LitCovid-sentences"},{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"},{"subj":"T211","pred":"source","obj":"LitCovid-sentences"},{"subj":"T212","pred":"source","obj":"LitCovid-sentences"},{"subj":"T213","pred":"source","obj":"LitCovid-sentences"},{"subj":"T214","pred":"source","obj":"LitCovid-sentences"},{"subj":"T215","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1113","span":{"begin":923,"end":931},"obj":"Disease"},{"id":"1121","span":{"begin":1178,"end":1183},"obj":"Gene"},{"id":"1122","span":{"begin":1033,"end":1034},"obj":"Gene"},{"id":"1123","span":{"begin":1007,"end":1015},"obj":"Species"},{"id":"1124","span":{"begin":1022,"end":1032},"obj":"Species"},{"id":"1125","span":{"begin":1124,"end":1131},"obj":"Species"},{"id":"1126","span":{"begin":1094,"end":1101},"obj":"Species"},{"id":"1127","span":{"begin":1115,"end":1123},"obj":"Disease"},{"id":"1144","span":{"begin":1561,"end":1562},"obj":"Gene"},{"id":"1145","span":{"begin":1550,"end":1560},"obj":"Species"},{"id":"1146","span":{"begin":1576,"end":1584},"obj":"Species"},{"id":"1147","span":{"begin":1585,"end":1592},"obj":"Species"},{"id":"1148","span":{"begin":1609,"end":1616},"obj":"Species"},{"id":"1149","span":{"begin":1646,"end":1653},"obj":"Species"},{"id":"1150","span":{"begin":1682,"end":1689},"obj":"Species"},{"id":"1151","span":{"begin":1719,"end":1726},"obj":"Species"},{"id":"1152","span":{"begin":1756,"end":1763},"obj":"Species"},{"id":"1153","span":{"begin":1512,"end":1519},"obj":"Species"},{"id":"1154","span":{"begin":1526,"end":1534},"obj":"Species"},{"id":"1155","span":{"begin":1600,"end":1608},"obj":"Disease"},{"id":"1156","span":{"begin":1637,"end":1645},"obj":"Disease"},{"id":"1157","span":{"begin":1673,"end":1681},"obj":"Disease"},{"id":"1158","span":{"begin":1710,"end":1718},"obj":"Disease"},{"id":"1159","span":{"begin":1747,"end":1755},"obj":"Disease"},{"id":"1163","span":{"begin":1480,"end":1488},"obj":"Species"},{"id":"1164","span":{"begin":1502,"end":1510},"obj":"Species"},{"id":"1165","span":{"begin":1493,"end":1501},"obj":"Disease"},{"id":"1171","span":{"begin":1939,"end":1944},"obj":"Gene"},{"id":"1172","span":{"begin":1808,"end":1809},"obj":"Gene"},{"id":"1173","span":{"begin":1784,"end":1792},"obj":"Species"},{"id":"1174","span":{"begin":1797,"end":1807},"obj":"Species"},{"id":"1175","span":{"begin":1865,"end":1872},"obj":"Species"},{"id":"1199","span":{"begin":416,"end":421},"obj":"Gene"},{"id":"1200","span":{"begin":748,"end":749},"obj":"Gene"},{"id":"1201","span":{"begin":637,"end":638},"obj":"Gene"},{"id":"1202","span":{"begin":455,"end":456},"obj":"Gene"},{"id":"1203","span":{"begin":242,"end":243},"obj":"Gene"},{"id":"1204","span":{"begin":113,"end":114},"obj":"Gene"},{"id":"1205","span":{"begin":102,"end":112},"obj":"Species"},{"id":"1206","span":{"begin":190,"end":198},"obj":"Species"},{"id":"1207","span":{"begin":216,"end":224},"obj":"Species"},{"id":"1208","span":{"begin":231,"end":241},"obj":"Species"},{"id":"1209","span":{"begin":300,"end":307},"obj":"Species"},{"id":"1210","span":{"begin":336,"end":344},"obj":"Species"},{"id":"1211","span":{"begin":431,"end":439},"obj":"Species"},{"id":"1212","span":{"begin":444,"end":454},"obj":"Species"},{"id":"1213","span":{"begin":498,"end":505},"obj":"Species"},{"id":"1214","span":{"begin":550,"end":558},"obj":"Species"},{"id":"1215","span":{"begin":626,"end":636},"obj":"Species"},{"id":"1216","span":{"begin":716,"end":724},"obj":"Species"},{"id":"1217","span":{"begin":737,"end":747},"obj":"Species"},{"id":"1218","span":{"begin":827,"end":835},"obj":"Species"},{"id":"1219","span":{"begin":181,"end":189},"obj":"Disease"},{"id":"1220","span":{"begin":327,"end":335},"obj":"Disease"},{"id":"1221","span":{"begin":707,"end":715},"obj":"Disease"}],"attributes":[{"id":"A1113","pred":"tao:has_database_id","subj":"1113","obj":"MESH:C000657245"},{"id":"A1121","pred":"tao:has_database_id","subj":"1121","obj":"Gene:59272"},{"id":"A1122","pred":"tao:has_database_id","subj":"1122","obj":"Gene:43740568"},{"id":"A1123","pred":"tao:has_database_id","subj":"1123","obj":"Tax:694009"},{"id":"A1124","pred":"tao:has_database_id","subj":"1124","obj":"Tax:2697049"},{"id":"A1125","pred":"tao:has_database_id","subj":"1125","obj":"Tax:9606"},{"id":"A1126","pred":"tao:has_database_id","subj":"1126","obj":"Tax:9606"},{"id":"A1127","pred":"tao:has_database_id","subj":"1127","obj":"MESH:C000657245"},{"id":"A1144","pred":"tao:has_database_id","subj":"1144","obj":"Gene:43740568"},{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"Tax:2697049"},{"id":"A1146","pred":"tao:has_database_id","subj":"1146","obj":"Tax:694009"},{"id":"A1147","pred":"tao:has_database_id","subj":"1147","obj":"Tax:9606"},{"id":"A1148","pred":"tao:has_database_id","subj":"1148","obj":"Tax:9606"},{"id":"A1149","pred":"tao:has_database_id","subj":"1149","obj":"Tax:9606"},{"id":"A1150","pred":"tao:has_database_id","subj":"1150","obj":"Tax:9606"},{"id":"A1151","pred":"tao:has_database_id","subj":"1151","obj":"Tax:9606"},{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"Tax:9606"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"Tax:9606"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"Tax:694009"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"MESH:C000657245"},{"id":"A1156","pred":"tao:has_database_id","subj":"1156","obj":"MESH:C000657245"},{"id":"A1157","pred":"tao:has_database_id","subj":"1157","obj":"MESH:C000657245"},{"id":"A1158","pred":"tao:has_database_id","subj":"1158","obj":"MESH:C000657245"},{"id":"A1159","pred":"tao:has_database_id","subj":"1159","obj":"MESH:C000657245"},{"id":"A1163","pred":"tao:has_database_id","subj":"1163","obj":"Tax:694009"},{"id":"A1164","pred":"tao:has_database_id","subj":"1164","obj":"Tax:9606"},{"id":"A1165","pred":"tao:has_database_id","subj":"1165","obj":"MESH:C000657245"},{"id":"A1171","pred":"tao:has_database_id","subj":"1171","obj":"Gene:59272"},{"id":"A1172","pred":"tao:has_database_id","subj":"1172","obj":"Gene:43740568"},{"id":"A1173","pred":"tao:has_database_id","subj":"1173","obj":"Tax:694009"},{"id":"A1174","pred":"tao:has_database_id","subj":"1174","obj":"Tax:2697049"},{"id":"A1175","pred":"tao:has_database_id","subj":"1175","obj":"Tax:9606"},{"id":"A1199","pred":"tao:has_database_id","subj":"1199","obj":"Gene:59272"},{"id":"A1200","pred":"tao:has_database_id","subj":"1200","obj":"Gene:43740568"},{"id":"A1201","pred":"tao:has_database_id","subj":"1201","obj":"Gene:43740568"},{"id":"A1202","pred":"tao:has_database_id","subj":"1202","obj":"Gene:43740568"},{"id":"A1203","pred":"tao:has_database_id","subj":"1203","obj":"Gene:43740568"},{"id":"A1204","pred":"tao:has_database_id","subj":"1204","obj":"Gene:43740568"},{"id":"A1205","pred":"tao:has_database_id","subj":"1205","obj":"Tax:2697049"},{"id":"A1206","pred":"tao:has_database_id","subj":"1206","obj":"Tax:9606"},{"id":"A1207","pred":"tao:has_database_id","subj":"1207","obj":"Tax:694009"},{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"Tax:2697049"},{"id":"A1209","pred":"tao:has_database_id","subj":"1209","obj":"Tax:9606"},{"id":"A1210","pred":"tao:has_database_id","subj":"1210","obj":"Tax:9606"},{"id":"A1211","pred":"tao:has_database_id","subj":"1211","obj":"Tax:694009"},{"id":"A1212","pred":"tao:has_database_id","subj":"1212","obj":"Tax:2697049"},{"id":"A1213","pred":"tao:has_database_id","subj":"1213","obj":"Tax:9606"},{"id":"A1214","pred":"tao:has_database_id","subj":"1214","obj":"Tax:694009"},{"id":"A1215","pred":"tao:has_database_id","subj":"1215","obj":"Tax:2697049"},{"id":"A1216","pred":"tao:has_database_id","subj":"1216","obj":"Tax:9606"},{"id":"A1217","pred":"tao:has_database_id","subj":"1217","obj":"Tax:2697049"},{"id":"A1218","pred":"tao:has_database_id","subj":"1218","obj":"Tax:694009"},{"id":"A1219","pred":"tao:has_database_id","subj":"1219","obj":"MESH:C000657245"},{"id":"A1220","pred":"tao:has_database_id","subj":"1220","obj":"MESH:C000657245"},{"id":"A1221","pred":"tao:has_database_id","subj":"1221","obj":"MESH:C000657245"},{"subj":"1113","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1121","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1122","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1123","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1124","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1127","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1154","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1155","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1156","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1171","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1172","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1173","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1174","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1175","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1199","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1209","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1213","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1214","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1215","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1216","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1217","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1218","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1219","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1221","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca1","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec939e"},{"id":"LitCovid-PD-MONDO","color":"#93b8ec"},{"id":"LitCovid-PD-CLO","color":"#d2ec93"},{"id":"LitCovid-PD-CHEBI","color":"#eb93ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecd1"},{"id":"LitCovid-sentences","color":"#ecb793"},{"id":"LitCovid-PubTator","color":"#9d93ec"}]}]}}