PMC:7100515 / 26805-29045
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T234 | 477-482 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T235 | 527-532 | Body_part | denotes | Serum | http://purl.org/sig/ont/fma/fma63083 |
| T236 | 1157-1162 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T237 | 1239-1244 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T238 | 1575-1580 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T239 | 1960-1968 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T240 | 2000-2005 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T241 | 2007-2012 | Body_part | denotes | Cells | http://purl.org/sig/ont/fma/fma68646 |
| T242 | 2106-2111 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 527-532 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T7 | 1157-1162 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T8 | 1575-1580 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T9 | 2106-2111 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T245 | 24-28 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T246 | 33-41 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T247 | 81-85 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T248 | 157-165 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T249 | 227-231 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T250 | 236-244 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T251 | 271-279 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T252 | 286-294 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T253 | 350-354 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T254 | 382-390 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T255 | 486-494 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T256 | 499-507 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T257 | 548-552 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T258 | 605-613 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T259 | 681-689 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T260 | 762-770 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T261 | 792-800 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T262 | 882-890 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T263 | 969-973 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T264 | 978-986 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T265 | 1062-1070 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T266 | 1077-1085 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T267 | 1144-1148 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T268 | 1170-1178 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T269 | 1535-1543 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T270 | 1548-1556 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T271 | 1581-1589 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T272 | 1605-1613 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T273 | 1631-1639 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T274 | 1655-1663 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T275 | 1692-1700 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T276 | 1728-1736 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T277 | 1765-1773 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T278 | 1802-1810 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T279 | 1839-1847 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T280 | 1852-1860 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T610 | 86-88 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T611 | 140-148 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T612 | 404-410 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T613 | 432-442 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T614 | 467-470 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T615 | 467-470 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T616 | 467-470 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T617 | 467-470 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T618 | 467-470 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T619 | 467-470 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T620 | 467-470 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T621 | 477-482 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T622 | 664-672 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T623 | 1164-1165 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T624 | 1193-1194 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T625 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T626 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T627 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T628 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T629 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T630 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T631 | 1229-1232 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T632 | 1239-1244 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T633 | 1464-1465 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T634 | 1507-1517 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T635 | 1954-1959 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T636 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T637 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T638 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T639 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T640 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T641 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T642 | 1990-1993 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T643 | 2000-2005 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T644 | 2007-2012 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cells |
| T645 | 2221-2222 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T217 | 1969-1976 | Chemical | denotes | mixture | http://purl.obolibrary.org/obo/CHEBI_60004 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T48 | 451-463 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T49 | 589-601 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T50 | 866-878 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T51 | 1258-1270 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T52 | 2051-2063 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T53 | 2134-2146 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T192 | 0-54 | Sentence | denotes | Cross-neutralization of SARS and COVID-19 patient sera |
| T193 | 55-313 | Sentence | denotes | As rabbit polyclonal anti-SARS S1 antibodies did not show significant neutralization activity against SARS-CoV-2 S pseudovirions, we then asked whether sera from recovered SARS and COVID-19 patients could neutralize SARS-CoV S and SARS-CoV-2 S pseudovirions. |
| T194 | 314-526 | Sentence | denotes | We obtained sera from one recovered SARS patient and five recovered COVID-19 patients and tested their neutralization activities against transduction on 293/hACE2 cells by SARS-CoV and SARS-CoV-2 S pseudovirions. |
| T195 | 527-729 | Sentence | denotes | Serum from recovered SARS patient showed strong inhibition on transduction by SARS-CoV S pseudovirions, and it had modest neutralization activity against SARS-CoV-2 S pseudovirons (Fig. 6a and Table 1). |
| T196 | 730-929 | Sentence | denotes | In contrast, sera from all five COVID-19 patients neutralized SARS-CoV-2 S pseudovirions effectively, and none of them had an effect on transduction by SARS-CoV S pseudovirions (Fig. 6b and Table 1). |
| T197 | 930-992 | Sentence | denotes | Fig. 6 Limited cross-neutralization of SARS and COVID-19 sera. |
| T198 | 993-1061 | Sentence | denotes | All sera were incubated on 56 °C for 30 min to eliminate complement. |
| T199 | 1062-1245 | Sentence | denotes | SARS-CoV S and SARS-CoV-2 S pseudovirons were pre-incubated with serially diluted SARS patient serum (a) or COVID-19 patient sera (b) for 1 h on ice and then added on 293/hACE2 cells. |
| T200 | 1246-1295 | Sentence | denotes | Pseudoviral transduction was measured 40 h later. |
| T201 | 1296-1385 | Sentence | denotes | Experiments were done in triplicates and repeated twice, and one representative is shown. |
| T202 | 1386-1435 | Sentence | denotes | Error bars indicate SEM of technical triplicates. |
| T203 | 1436-1483 | Sentence | denotes | Source data are provided as a Source Data file. |
| T204 | 1484-1566 | Sentence | denotes | Table 1 Neutralization activities of antisera from SARS-CoV and COVID-19 patients. |
| T205 | 1567-1630 | Sentence | denotes | Patient serum SARS-CoV S pseudovirion SARS-CoV-2 S pseudovirion |
| T206 | 1631-1654 | Sentence | denotes | SARS-CoV patient >80 40 |
| T207 | 1655-1691 | Sentence | denotes | COVID-19 patient #1 Not detected >80 |
| T208 | 1692-1727 | Sentence | denotes | COVID-19 patient #2 Not detected 40 |
| T209 | 1728-1764 | Sentence | denotes | COVID-19 patient #3 Not detected >80 |
| T210 | 1765-1801 | Sentence | denotes | COVID-19 patient #4 Not detected >80 |
| T211 | 1802-1838 | Sentence | denotes | COVID-19 patient #5 Not detected >80 |
| T212 | 1839-2006 | Sentence | denotes | SARS-CoV and SARS-CoV-2 S pseudovirions were pre-incubated with serially diluted patient sera for 1 h on ice, then virus-antibody mixture was added on 293/hACE2 cells. |
| T213 | 2007-2077 | Sentence | denotes | Cells were lysed 40 h later and pseudovirus transduction was measured. |
| T214 | 2078-2192 | Sentence | denotes | The highest dilution of the serum sample that decreased transduction by 50% or more was considered to be positive. |
| T215 | 2193-2240 | Sentence | denotes | Source data are provided as a Source Data file. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1110 | 42-49 | Species | denotes | patient | Tax:9606 |
| 1111 | 33-41 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1113 | 978-986 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1121 | 1233-1238 | Gene | denotes | hACE2 | Gene:59272 |
| 1122 | 1088-1089 | Gene | denotes | S | Gene:43740568 |
| 1123 | 1062-1070 | Species | denotes | SARS-CoV | Tax:694009 |
| 1124 | 1077-1087 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1125 | 1179-1186 | Species | denotes | patient | Tax:9606 |
| 1126 | 1149-1156 | Species | denotes | patient | Tax:9606 |
| 1127 | 1170-1178 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1144 | 1616-1617 | Gene | denotes | S | Gene:43740568 |
| 1145 | 1605-1615 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1146 | 1631-1639 | Species | denotes | SARS-CoV | Tax:694009 |
| 1147 | 1640-1647 | Species | denotes | patient | Tax:9606 |
| 1148 | 1664-1671 | Species | denotes | patient | Tax:9606 |
| 1149 | 1701-1708 | Species | denotes | patient | Tax:9606 |
| 1150 | 1737-1744 | Species | denotes | patient | Tax:9606 |
| 1151 | 1774-1781 | Species | denotes | patient | Tax:9606 |
| 1152 | 1811-1818 | Species | denotes | patient | Tax:9606 |
| 1153 | 1567-1574 | Species | denotes | Patient | Tax:9606 |
| 1154 | 1581-1589 | Species | denotes | SARS-CoV | Tax:694009 |
| 1155 | 1655-1663 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1156 | 1692-1700 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1157 | 1728-1736 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1158 | 1765-1773 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1159 | 1802-1810 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1163 | 1535-1543 | Species | denotes | SARS-CoV | Tax:694009 |
| 1164 | 1557-1565 | Species | denotes | patients | Tax:9606 |
| 1165 | 1548-1556 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1171 | 1994-1999 | Gene | denotes | hACE2 | Gene:59272 |
| 1172 | 1863-1864 | Gene | denotes | S | Gene:43740568 |
| 1173 | 1839-1847 | Species | denotes | SARS-CoV | Tax:694009 |
| 1174 | 1852-1862 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1175 | 1920-1927 | Species | denotes | patient | Tax:9606 |
| 1199 | 471-476 | Gene | denotes | hACE2 | Gene:59272 |
| 1200 | 803-804 | Gene | denotes | S | Gene:43740568 |
| 1201 | 692-693 | Gene | denotes | S | Gene:43740568 |
| 1202 | 510-511 | Gene | denotes | S | Gene:43740568 |
| 1203 | 297-298 | Gene | denotes | S | Gene:43740568 |
| 1204 | 168-169 | Gene | denotes | S | Gene:43740568 |
| 1205 | 157-167 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1206 | 245-253 | Species | denotes | patients | Tax:9606 |
| 1207 | 271-279 | Species | denotes | SARS-CoV | Tax:694009 |
| 1208 | 286-296 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1209 | 355-362 | Species | denotes | patient | Tax:9606 |
| 1210 | 391-399 | Species | denotes | patients | Tax:9606 |
| 1211 | 486-494 | Species | denotes | SARS-CoV | Tax:694009 |
| 1212 | 499-509 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1213 | 553-560 | Species | denotes | patient | Tax:9606 |
| 1214 | 605-613 | Species | denotes | SARS-CoV | Tax:694009 |
| 1215 | 681-691 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1216 | 771-779 | Species | denotes | patients | Tax:9606 |
| 1217 | 792-802 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1218 | 882-890 | Species | denotes | SARS-CoV | Tax:694009 |
| 1219 | 236-244 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1220 | 382-390 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1221 | 762-770 | Disease | denotes | COVID-19 | MESH:C000657245 |