PMC:7094172 / 38513-39381 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T175","span":{"begin":312,"end":319},"obj":"Body_part"},{"id":"T176","span":{"begin":335,"end":338},"obj":"Body_part"}],"attributes":[{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T124","span":{"begin":180,"end":183},"obj":"Disease"},{"id":"T126","span":{"begin":232,"end":235},"obj":"Disease"},{"id":"T128","span":{"begin":516,"end":525},"obj":"Disease"}],"attributes":[{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A125","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A127","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T288","span":{"begin":192,"end":194},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T289","span":{"begin":266,"end":268},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T290","span":{"begin":266,"end":268},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T291","span":{"begin":482,"end":490},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T292","span":{"begin":510,"end":515},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T293","span":{"begin":526,"end":531},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T294","span":{"begin":541,"end":543},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T295","span":{"begin":612,"end":614},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T296","span":{"begin":732,"end":734},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T297","span":{"begin":732,"end":734},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T362","span":{"begin":266,"end":268},"obj":"Chemical"},{"id":"T363","span":{"begin":312,"end":319},"obj":"Chemical"},{"id":"T364","span":{"begin":381,"end":383},"obj":"Chemical"},{"id":"T365","span":{"begin":428,"end":437},"obj":"Chemical"},{"id":"T366","span":{"begin":467,"end":469},"obj":"Chemical"},{"id":"T367","span":{"begin":472,"end":481},"obj":"Chemical"},{"id":"T368","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"T369","span":{"begin":732,"end":734},"obj":"Chemical"},{"id":"T370","span":{"begin":787,"end":789},"obj":"Chemical"}],"attributes":[{"id":"A362","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A363","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A364","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A365","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A366","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_29401"},{"id":"A367","pred":"chebi_id","subj":"T367","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A368","pred":"chebi_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A369","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A370","pred":"chebi_id","subj":"T370","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T29","span":{"begin":312,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0050821"},{"id":"T30","span":{"begin":312,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0045185"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":516,"end":525},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T310","span":{"begin":0,"end":32},"obj":"Sentence"},{"id":"T311","span":{"begin":33,"end":823},"obj":"Sentence"},{"id":"T312","span":{"begin":824,"end":868},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"631","span":{"begin":169,"end":177},"obj":"Species"},{"id":"632","span":{"begin":221,"end":229},"obj":"Species"},{"id":"633","span":{"begin":301,"end":309},"obj":"Species"},{"id":"634","span":{"begin":510,"end":531},"obj":"Species"},{"id":"635","span":{"begin":505,"end":508},"obj":"Species"}],"attributes":[{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"Tax:1335626"},{"id":"A632","pred":"tao:has_database_id","subj":"632","obj":"Tax:1335626"},{"id":"A633","pred":"tao:has_database_id","subj":"633","obj":"Tax:1335626"},{"id":"A634","pred":"tao:has_database_id","subj":"634","obj":"Tax:11138"},{"id":"A635","pred":"tao:has_database_id","subj":"635","obj":"Tax:11138"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Supporting Information Available\nThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)\nMolecular Formula Strings_JMC_revision (CSV)"}