PMC:7094172 / 38513-39381
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T175 | 312-319 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T176 | 335-338 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T124 | 180-183 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T126 | 232-235 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T128 | 516-525 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T288 | 192-194 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T289 | 266-268 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T290 | 266-268 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T291 | 482-490 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T292 | 510-515 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T293 | 526-531 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T294 | 541-543 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
| T295 | 612-614 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T296 | 732-734 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T297 | 732-734 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T362 | 266-268 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T363 | 312-319 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T364 | 381-383 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
| T365 | 428-437 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T366 | 467-469 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T367 | 472-481 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T368 | 541-543 | Chemical | denotes | S5 | http://purl.obolibrary.org/obo/CHEBI_29386 |
| T369 | 732-734 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T370 | 787-789 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29 | 312-330 | http://purl.obolibrary.org/obo/GO_0050821 | denotes | protein sequesters |
| T30 | 312-330 | http://purl.obolibrary.org/obo/GO_0045185 | denotes | protein sequesters |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T6 | 516-525 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T310 | 0-32 | Sentence | denotes | Supporting Information Available |
| T311 | 33-823 | Sentence | denotes | The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01913.Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF) |
| T312 | 824-868 | Sentence | denotes | Molecular Formula Strings_JMC_revision (CSV) |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 631 | 169-177 | Species | denotes | MERS-CoV | Tax:1335626 |
| 632 | 221-229 | Species | denotes | MERS-CoV | Tax:1335626 |
| 633 | 301-309 | Species | denotes | MERS-CoV | Tax:1335626 |
| 634 | 510-531 | Species | denotes | mouse hepatitis virus | Tax:11138 |
| 635 | 505-508 | Species | denotes | MHV | Tax:11138 |