
PMC:7091888 / 4966-6821
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
220 | 1120-1121 | Gene | denotes | S | Gene:43740568 |
221 | 955-965 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
222 | 1012-1022 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
223 | 1024-1032 | Species | denotes | SARS-CoV | Tax:694009 |
224 | 1038-1046 | Species | denotes | MERS-CoV | Tax:1335626 |
225 | 1109-1119 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
226 | 1136-1144 | Species | denotes | SARS-CoV | Tax:694009 |
227 | 1165-1173 | Species | denotes | MERS-CoV | Tax:1335626 |
228 | 1215-1225 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
229 | 1230-1238 | Species | denotes | SARS-CoV | Tax:694009 |
230 | 1293-1303 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
231 | 1305-1313 | Species | denotes | SARS-CoV | Tax:694009 |
232 | 1319-1327 | Species | denotes | MERS-CoV | Tax:1335626 |
233 | 1591-1601 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
234 | 1675-1683 | Species | denotes | SARS-CoV | Tax:694009 |
235 | 1688-1696 | Species | denotes | MERS-CoV | Tax:1335626 |
236 | 1762-1766 | Species | denotes | mice | Tax:10090 |
237 | 1782-1790 | Species | denotes | SARS-CoV | Tax:694009 |
238 | 1047-1052 | Gene | denotes | spike | Gene:43740568 |
239 | 1542-1545 | Chemical | denotes | SDS | MESH:D012967 |
253 | 37-45 | Species | denotes | SARS-CoV | Tax:694009 |
254 | 50-60 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
255 | 90-100 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
256 | 346-355 | Species | denotes | mammalian | Tax:9606 |
257 | 465-473 | Species | denotes | SARS-CoV | Tax:694009 |
258 | 509-519 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
259 | 596-606 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
260 | 611-619 | Species | denotes | SARS-CoV | Tax:694009 |
261 | 644-652 | Species | denotes | SARS-CoV | Tax:694009 |
262 | 866-874 | Species | denotes | SARS-CoV | Tax:694009 |
263 | 904-914 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
264 | 263-268 | Species | denotes | human | Tax:9606 |
265 | 361-365 | CellLine | denotes | 293T | CVCL:0063 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T20 | 133-140 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T21 | 190-197 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T22 | 335-342 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T23 | 356-360 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T24 | 388-392 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T25 | 419-426 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T26 | 491-498 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T27 | 524-531 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T28 | 919-926 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T29 | 1057-1065 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T30 | 1187-1197 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T31 | 1611-1618 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T94 | 37-45 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T95 | 37-41 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T96 | 50-58 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T97 | 50-54 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T98 | 90-98 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T99 | 90-94 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T100 | 465-473 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T101 | 465-469 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T102 | 509-517 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T103 | 509-513 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T104 | 596-604 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T105 | 596-600 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T106 | 611-619 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T107 | 611-615 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T108 | 644-652 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T109 | 644-648 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T110 | 866-874 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T111 | 866-870 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T112 | 904-912 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T113 | 904-908 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T114 | 955-963 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T115 | 955-959 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T116 | 1012-1020 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T117 | 1012-1016 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T118 | 1024-1032 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T119 | 1024-1028 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T120 | 1109-1117 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T121 | 1109-1113 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T122 | 1136-1144 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T123 | 1136-1140 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T124 | 1215-1223 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T125 | 1215-1219 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T126 | 1230-1238 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T127 | 1230-1234 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T128 | 1293-1301 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T129 | 1293-1297 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T130 | 1305-1313 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T131 | 1305-1309 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T132 | 1591-1599 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T133 | 1591-1595 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T134 | 1675-1683 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T135 | 1675-1679 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T136 | 1782-1790 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T137 | 1782-1786 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T43 | 172-173 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T44 | 244-245 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T45 | 257-259 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T46 | 263-268 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T47 | 356-360 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T48 | 361-365 | http://purl.obolibrary.org/obo/CLO_0050894 | denotes | 293T |
T49 | 361-365 | http://purl.obolibrary.org/obo/CLO_0051650 | denotes | 293T |
T50 | 361-365 | http://purl.obolibrary.org/obo/CLO_0052052 | denotes | 293T |
T51 | 388-392 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T52 | 427-428 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T53 | 971-972 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T54 | 1187-1206 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
T55 | 1187-1206 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
T56 | 1401-1407 | http://purl.obolibrary.org/obo/UBERON_0001155 | denotes | colons |
T57 | 1552-1553 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T27 | 133-140 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T28 | 190-197 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T29 | 335-342 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T30 | 419-426 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T31 | 491-498 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T32 | 524-531 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T33 | 919-926 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T34 | 1057-1065 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T35 | 1187-1197 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T36 | 1187-1192 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T37 | 1193-1197 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T38 | 1542-1545 | Chemical | denotes | SDS | http://purl.obolibrary.org/obo/CHEBI_8984 |
T39 | 1611-1618 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T18 | 0-151 | Sentence | denotes | By alignment of the RBD sequences of SARS-CoV and SARS-CoV-2, we identified the region of SARS-CoV-2 RBD at residues 331 to 524 of S protein (Fig. 1a). |
T19 | 152-453 | Sentence | denotes | We then constructed a recombinant RBD protein containing codon-optimized RBD sequences with a C-terminal Fc of human IgG1 (hFc) using pFUSE-hIgG1-Fc2 expression vector, expressed the protein in mammalian cell 293T, and purified it from cell culture supernatant using protein A affinity chromatography. |
T20 | 454-581 | Sentence | denotes | Similar to SARS-CoV and MERS-CoV RBD protein controls, SARS-CoV-2 RBD protein had high expression with strong purity (Fig. 1b). |
T21 | 582-927 | Sentence | denotes | Notably, only SARS-CoV-2 and SARS-CoV RBDs were recognized by SARS-CoV RBD-specific, but not MERS-CoV RBD-specific, polyclonal antibodies (Fig. 1c), whereas only MERS-CoV RBD was recognized by MERS-CoV RBD-immunized polyclonal antibodies (Fig. 1d), suggesting the cross-reactivity of SARS-CoV RBD-specific antibodies with SARS-CoV-2 RBD protein. |
T22 | 928-1066 | Sentence | denotes | Fig. 1 Characterization of SARS-CoV-2 RBD. a Multiple sequence alignment of RBDs of SARS-CoV-2, SARS-CoV, and MERS-CoV spike (S) proteins. |
T23 | 1067-1177 | Sentence | denotes | GenBank accession numbers are QHR63250.1 (SARS-CoV-2 S), AY278488.2 (SARS-CoV S), and AFS88936.1 (MERS-CoV S). |
T24 | 1178-1354 | Sentence | denotes | Variable amino acid residues between SARS-CoV-2 and SARS-CoV are highlighted in cyan, and conserved residues among SARS-CoV-2, SARS-CoV, and MERS-CoV are highlighted in yellow. |
T25 | 1355-1492 | Sentence | denotes | Asterisks represent fully conserved residues, colons represent highly conserved residues, and periods represent lowly conserved residues. |
T26 | 1493-1541 | Sentence | denotes | The alignment was performed using Clustal Omega. |
T27 | 1542-1606 | Sentence | denotes | SDS-PAGE (b) and Western blot (c, d) analysis of SARS-CoV-2 RBD. |
T28 | 1607-1674 | Sentence | denotes | The protein molecular weight marker (kDa) is indicated on the left. |
T29 | 1675-1728 | Sentence | denotes | SARS-CoV and MERS-CoV RBDs were included as controls. |
T30 | 1729-1855 | Sentence | denotes | Antisera (1:3,000 dilution) from mice immunized with SARS-CoV RBD (c) and MERS-CoV RBD (d) were used for Western blot analysis |