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PMC:7091888 / 24514-26543 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1005 113-118 Gene denotes hACE2 Gene:59272
1006 160-165 Gene denotes hACE2 Gene:59272
1007 167-177 Gene denotes hACE2/293T Gene:59272
1008 269-279 Gene denotes hDPP4/293T Gene:1803
1009 703-707 Gene denotes ACE2 Gene:59272
1010 939-943 Gene denotes DPP4 Gene:1803
1011 87-97 Species denotes SARS-CoV-2 Tax:2697049
1012 185-193 Species denotes SARS-CoV Tax:694009
1013 198-206 Species denotes MERS-CoV Tax:1335626
1014 358-368 Species denotes SARS-CoV-2 Tax:2697049
1015 370-378 Species denotes SARS-CoV Tax:694009
1016 383-391 Species denotes MERS-CoV Tax:1335626
1017 697-702 Species denotes human Tax:9606
1018 787-797 Species denotes SARS-CoV-2 Tax:2697049
1019 799-807 Species denotes SARS-CoV Tax:694009
1020 812-820 Species denotes MERS-CoV Tax:1335626
1021 933-938 Species denotes human Tax:9606
1022 525-530 Species denotes human Tax:9606
1023 502-506 Chemical denotes FITC MESH:D016650
1024 945-950 Chemical denotes sDPP4
1025 131-135 CellLine denotes 293T CVCL:0063
1026 224-228 CellLine denotes 293T CVCL:0063
1027 751-753 CellLine denotes MN CVCL:U508
1035 1022-1027 Gene denotes hACE2 Gene:59272
1036 1050-1060 Gene denotes hACE2/293T Gene:59272
1037 1065-1070 Gene denotes hDPP4 Gene:1803
1038 1093-1103 Gene denotes hDPP4/293T Gene:1803
1039 1240-1245 Gene denotes hACE2 Gene:59272
1040 1250-1255 Gene denotes hDPP4 Gene:1803
1041 1339-1343 Chemical denotes FITC MESH:D016650
1054 1514-1519 Gene denotes hACE2 Gene:59272
1055 1528-1532 Gene denotes ACE2 Gene:59272
1056 1632-1637 Gene denotes hACE2 Gene:59272
1057 1495-1505 Species denotes SARS-CoV-2 Tax:2697049
1058 1732-1742 Species denotes SARS-CoV-2 Tax:2697049
1059 1813-1821 Species denotes SARS-CoV Tax:694009
1060 1826-1834 Species denotes MERS-CoV Tax:1335626
1061 1913-1918 Species denotes human Tax:9606
1062 1665-1682 Chemical denotes calcium phosphate MESH:C020243
1063 1887-1891 Chemical denotes FITC MESH:D016650
1064 1578-1582 CellLine denotes 293T CVCL:0063
1065 1599-1603 CellLine denotes 293T CVCL:0063

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T196 102-109 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T197 136-141 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T198 229-234 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T199 314-319 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T200 531-534 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T201 535-543 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T202 897-904 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T203 1028-1035 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 1071-1078 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T205 1112-1116 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T206 1201-1206 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 1270-1278 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T208 1362-1365 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T209 1366-1374 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T210 1583-1588 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T211 1604-1609 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T212 1747-1754 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T213 1919-1922 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T214 1923-1931 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T448 87-95 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T449 87-91 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T450 185-193 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T451 185-189 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T452 358-366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T453 358-362 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T454 370-378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T455 370-374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T456 787-795 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T457 787-791 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T458 799-807 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T459 799-803 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T460 1495-1503 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T461 1495-1499 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T462 1732-1740 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T463 1732-1736 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T464 1813-1821 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T465 1813-1817 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T413 131-135 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T414 131-135 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T415 131-135 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T416 136-141 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T417 173-177 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T418 173-177 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T419 173-177 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T420 224-228 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T421 224-228 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T422 224-228 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T423 229-234 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T424 275-279 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T425 275-279 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T426 275-279 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T427 314-319 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T428 403-404 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T429 507-514 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T430 515-519 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T431 525-534 http://purl.obolibrary.org/obo/CLO_0053695 denotes human IgG
T432 697-702 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T433 725-728 http://purl.obolibrary.org/obo/CLO_0008693 denotes R&D
T434 725-728 http://purl.obolibrary.org/obo/CLO_0008770 denotes R&D
T435 894-896 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T436 933-938 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T437 961-964 http://purl.obolibrary.org/obo/CLO_0008693 denotes R&D
T438 961-964 http://purl.obolibrary.org/obo/CLO_0008770 denotes R&D
T439 1056-1060 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T440 1056-1060 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T441 1056-1060 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T442 1099-1103 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T443 1099-1103 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T444 1099-1103 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T445 1112-1122 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T446 1201-1206 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T447 1265-1269 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T448 1291-1294 http://purl.obolibrary.org/obo/CLO_0008693 denotes R&D
T449 1291-1294 http://purl.obolibrary.org/obo/CLO_0008770 denotes R&D
T450 1344-1351 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T451 1357-1361 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T452 1416-1420 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 °C
T453 1524-1527 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T454 1578-1582 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T455 1578-1582 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T456 1578-1582 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T457 1583-1588 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T458 1599-1603 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T459 1599-1603 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T460 1599-1603 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T461 1604-1609 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T462 1695-1697 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T463 1903-1907 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T464 1913-1922 http://purl.obolibrary.org/obo/CLO_0053695 denotes human IgG

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T124 102-109 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 502-506 Chemical denotes FITC http://purl.obolibrary.org/obo/CHEBI_37926
T126 751-753 Chemical denotes MN http://purl.obolibrary.org/obo/CHEBI_141442
T127 897-904 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T128 1028-1035 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T129 1071-1078 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T130 1339-1343 Chemical denotes FITC http://purl.obolibrary.org/obo/CHEBI_37926
T131 1401-1403 Chemical denotes MA http://purl.obolibrary.org/obo/CHEBI_474859|http://purl.obolibrary.org/obo/CHEBI_73610|http://purl.obolibrary.org/obo/CHEBI_90325
T134 1665-1682 Chemical denotes calcium phosphate http://purl.obolibrary.org/obo/CHEBI_77635|http://purl.obolibrary.org/obo/CHEBI_9679
T136 1665-1672 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T138 1673-1682 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T142 1747-1754 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T143 1887-1891 Chemical denotes FITC http://purl.obolibrary.org/obo/CHEBI_37926
T144 1971-1978 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T143 0-23 Sentence denotes Flow cytometry analysis
T144 24-304 Sentence denotes Flow cytometry analysis was performed to detect the binding of SARS-CoV-2 RBD protein to hACE2 receptor in 293T cells stably expressing hACE2 (hACE2/293T).26,32 SARS-CoV and MERS-CoV RBDs, as well as 293T cells stably expressing hDPP4 receptor (hDPP4/293T), were used as controls.
T145 305-620 Sentence denotes Briefly, cells were incubated with respective RBD of SARS-CoV-2, SARS-CoV, or MERS-CoV containing a C-terminal hFc at 20 μg/ml for 30 min at room temperature, which was followed by incubation with FITC-labeled goat anti-human IgG antibody (1:500; Thermo Fisher Scientific) for 30 min and analyzed by flow cytometry.
T146 621-910 Sentence denotes The blockage of RBD-receptor binding was performed by incubation of soluble human ACE2 (sACE2; 5 μg/ml; R&D Systems, Minneapolis, MN) receptor with respective RBD of SARS-CoV-2, SARS-CoV, or MERS-CoV (20 μg/ml), followed by the same procedure as that described above. hIgG-Fc protein (hFc:
T147 911-1008 Sentence denotes 20 μg/ml), or soluble human DPP4 (sDPP4; 5 μg/ml; R&D Systems) receptor, was included as control.
T148 1009-1421 Sentence denotes Detection of hACE2 protein expression in hACE2/293T, or hDPP4 protein expression in hDPP4/293T, stable cell lines was performed by flow cytometry analysis, as described above, except that the cells were sequentially incubated with hACE2- or hDPP4-specific goat antibody (0.5 μg/ml; R&D Systems) at room temperature for 20 min and FITC-labeled anti-goat IgG antibody (1:200; Abcam, Cambridge, MA) for 1 h at 4 °C.
T149 1422-1589 Sentence denotes Flow cytometry analysis was also performed to detect the binding between SARS-CoV-2 RBD and hACE2, or bat-ACE2 (bACE2), receptor in transiently transfected 293T cells.
T150 1590-1812 Sentence denotes Briefly, 293T cells were transfected with hACE2 or bACE2 plasmid using the calcium phosphate method, and 48 h later, they were incubated with SARS-CoV-2 RBD protein at various concentrations for 30 min at room temperature.
T151 1813-1866 Sentence denotes SARS-CoV and MERS-CoV RBDs were included as controls.
T152 1867-2029 Sentence denotes After staining with FITC-conjugated goat anti-human IgG antibody (1:500; Thermo Fisher Scientific), the mixture was analyzed by flow cytometry as described above.

2_test

Id Subject Object Predicate Lexical cue
32203189-24719424-19774542 179-181 24719424 denotes 26
32203189-23824801-19774543 182-184 23824801 denotes 32