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PMC:7091888 / 21585-22720 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
909 126-130 Gene denotes ACE2 Gene:59272
910 244-248 Gene denotes ACE2 Gene:59272
911 398-402 Gene denotes ACE2 Gene:59272
912 303-304 Gene denotes S Gene:43740568
913 38-48 Species denotes SARS-CoV-2 Tax:2697049
914 146-151 Species denotes human Tax:9606
915 254-262 Species denotes SARS-CoV Tax:694009
916 268-278 Species denotes SARS-CoV-2 Tax:2697049
917 322-332 Species denotes SARS-CoV-2 Tax:2697049
918 349-357 Species denotes SARS-CoV Tax:694009
919 465-475 Species denotes SARS-CoV-2 Tax:2697049
920 537-547 Species denotes SARS-CoV-2 Tax:2697049
921 552-560 Species denotes SARS-CoV Tax:694009
922 562-570 Species denotes SARS-CoV Tax:694009
923 617-627 Species denotes SARS-CoV-2 Tax:2697049
924 703-711 Species denotes SARS-CoV Tax:694009
925 802-810 Species denotes SARS-CoV Tax:694009
926 826-836 Species denotes SARS-CoV-2 Tax:2697049
927 960-970 Species denotes SARS-CoV-2 Tax:2697049
928 1088-1098 Species denotes SARS-CoV-2 Tax:2697049
929 653-685 Disease denotes SARS-CoV-2 pseudovirus infection MESH:C000657245
930 765-785 Disease denotes SARS-CoV-2 infection MESH:C000657245
931 974-992 Disease denotes SARS-CoV infection MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T167 53-60 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T168 98-102 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T169 177-184 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 283-290 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T171 305-312 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 430-435 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T173 480-487 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 815-822 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T175 841-848 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T395 38-46 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T396 38-42 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T397 254-262 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T398 254-258 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T399 268-276 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T400 268-272 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T401 322-330 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T402 322-326 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T403 349-357 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T404 349-353 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T405 465-473 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T406 465-469 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T407 537-545 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T408 537-541 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T409 552-560 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T410 552-556 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T411 562-570 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T412 562-566 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T413 617-625 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T414 617-621 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T415 653-661 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T416 653-657 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T417 676-685 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T418 703-711 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T419 703-707 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T420 765-773 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T421 765-769 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T422 776-785 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T423 802-810 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T424 802-806 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T425 826-834 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T426 826-830 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 960-968 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T428 960-964 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T429 974-992 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T430 974-978 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T431 983-992 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T432 1088-1096 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T433 1088-1092 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T389 98-102 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T390 146-151 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T391 156-159 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T392 430-435 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T393 491-492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T394 864-865 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T87 53-60 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 177-184 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 283-290 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T90 305-312 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 480-487 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T92 519-528 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93 815-822 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 841-848 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T130 0-167 Sentence denotes In summary, we have characterized the SARS-CoV-2 RBD protein which exhibits strong binding to its cell-associated and soluble ACE2 receptors with human and bat origin.
T131 168-267 Sentence denotes This RBD protein also demonstrated significantly higher binding affinity to ACE2 than SARS-CoV RBD.
T132 268-561 Sentence denotes SARS-CoV-2 RBD protein could block S protein-mediated SARS-CoV-2 pseudovirus and SARS-CoV pseudovirus entry into their respective ACE2 receptor-expressing target cells, suggesting the potential of SARS-CoV-2 RBD protein as a viral attachment or entry inhibitor against SARS-CoV-2 and SARS-CoV.
T133 562-993 Sentence denotes SARS-CoV RBD-induced antibodies could cross-react with SARS-CoV-2 RBD and cross-neutralize SARS-CoV-2 pseudovirus infection, indicating that SARS-CoV RBD-specific antibodies may be used for treatment of SARS-CoV-2 infection and that either SARS-CoV RBD protein or SARS-CoV-2 RBD protein may be used as a candidate vaccine to induce cross-reactive or cross-neutralizing antibodies for prevention of SARS-CoV-2 or SARS-CoV infection.
T134 994-1135 Sentence denotes Taken together, this study provides an essential foundation for the design and development of SARS-CoV-2 RBD-based vaccines and therapeutics.