PMC:7088323 / 7794-8895 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7088323","sourcedb":"PMC","sourceid":"7088323","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7088323","text":"Consolidation refers to alveolar air being replaced by pathological fluids, cells, or tissues, manifested by an increase in pulmonary parenchymal density that obscures the margins of underlying vessels and airway walls [26]. Multifocal, patchy, or segmental consolidation, distributed in subpleural areas or along bronchovascular bundles, is usually presented in COVID-19 patients (Fig. 1b) with occurrence rate of 2~64% [12, 15, 23]. In COVID-19 patients, consolidation may relate to cellular fibromyxoid exudates in alveoli [27]. In addition, consolidation was considered as an indication of disease progression. A recent study showed lung involvement gradually increased to consolidation up to 2 weeks after disease onset [20], which concurs with another conclusion that GGO could progress to or co-existed with consolidations within 1–3 weeks [18]. Likewise, Song et al found more consolidative lesions in patients with longer time interval between symptom onset and CT scan or older than 50 years old [19], suggesting that this manifestation could serve as an alert in the management of 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