PMC:7088323 / 6198-7778
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7088323","sourcedb":"PMC","sourceid":"7088323","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7088323","text":"Ground glass opacity\nGGO were defined as hazy areas with slightly increased density in lungs without obscuration of bronchial and vascular margins, which may be caused by partial displacement of air due to partial filling of airspaces or interstitial thickening [26]. In patients with COVID-19, unilaterally or bilaterally GGO with a peripheral lung and subpleural distribution are commonly encountered [16, 19, 22] (Fig. 1a). In the very first radiologic investigation of 21 patients by Chung et al [9], GGO was found in 57% patients and was believed to be the earliest radiographically visible CT manifestation in some patients. These results are consistent with those of other subsequent studies, presenting GGO as the most common imaging finding with occurrence rate of up to 98% [23]. Recently, the first post-mortem biopsy in a COVID-19 patient was reported [27], showing pulmonary edema and hyaline membrane formation in both lungs, which we speculate may be the underlying pathological driver of GGO sign. Moreover, GGO are often accompanied by other features or patterns, including reticular and/or interlobular septal thickening and consolidation [19]. GGO together with small areas of consolidation may suggest an organizing pneumonia pattern of lung injury [28].\nFig. 1 a A 35-year-old male COVID-19 patient presenting fever and headache for 1 day. CT scan shows a pure ground glass opacity in the right lower lobe (red frame). b A 47-year-old male COVID-19 patient presenting fever for 7 days. 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