PMC:7080117 / 2490-4983 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7080117","sourcedb":"PMC","sourceid":"7080117","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7080117","text":"Introduction\nIn December 2019, a series of pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) break out in Wuhan, Hubei, China. Since then, the COVID-19 confirmed cases are increasing rapidly. As of February 10, 2020, a total of 40,265 confirmed cases have been reported in China, with another 23,589 suspected cases, 909 fatal cases, and 3501 discharged patients. Moreover, more than 300 similar cases have been identified in other 24 countries. On December 30, 2019, WHO announced the event constituted a Public Health Emergency of International Concern (PHEIC), indicating that a big threat to global health has been posed by the novel coronavirus infections.\nSARS-CoV-2 is a betacoronavirus that belongs to the family Coronaviridae and the order Nidovirales [1]. Up to date, six coronavirus species have been identified to infect humans and cause disease. Among them, 229E, OC43, NL63, and HKU1 infections are frequently mild, mostly caused common cold symptoms [2]. The other two species, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), might cause fatal illness [3]. SARS-CoV-2 is the seventh member of the coronaviruses that infects humans [4]. Infected patients predominantly presented with fever, cough, and radiological ground glass lung opacities, which resemble SARS-CoV and MERS-CoV infections [5].\nA recent publication reported a familial cluster of pneumonia linked to SARS-CoV-2, which indicated the human transmission of the disease [6]. In this family, a 10-year-old child had ground glass lung opacification, but no clinical symptoms. The patient was confirmed to be affected by this novel coronavirus by real-time polymerase chain reaction (PCR). These findings indicate that some patients with SARS-CoV-2 infection are asymptomatic. If some people have a clear history of exposure, regardless of clinical symptoms, or if they present suggestive clinical manifestations, regardless of history of exposure, it is necessary to confirm whether they are infected by chest CT or SARS-CoV-2 nucleic acid tests.\nChest CT plays an important role in timely detecting lung abnormalities, allowing for early treatment. We aimed at describing clinical and CT imaging characteristics of 90 patients with SARS-CoV-2 infection and early follow-up appearances of 52 patients. We hope our findings will provide useful information for medical imagers to recognize the COVID-19 pneumonia and assess its 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