PMC:7080035 / 8119-9569 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T61","span":{"begin":329,"end":334},"obj":"Body_part"},{"id":"T62","span":{"begin":438,"end":442},"obj":"Body_part"},{"id":"T63","span":{"begin":595,"end":600},"obj":"Body_part"},{"id":"T64","span":{"begin":673,"end":678},"obj":"Body_part"},{"id":"T65","span":{"begin":877,"end":888},"obj":"Body_part"},{"id":"T66","span":{"begin":877,"end":882},"obj":"Body_part"},{"id":"T67","span":{"begin":896,"end":907},"obj":"Body_part"},{"id":"T68","span":{"begin":1145,"end":1150},"obj":"Body_part"},{"id":"T69","span":{"begin":1365,"end":1370},"obj":"Body_part"},{"id":"T70","span":{"begin":1397,"end":1408},"obj":"Body_part"},{"id":"T71","span":{"begin":1397,"end":1402},"obj":"Body_part"},{"id":"T72","span":{"begin":1416,"end":1427},"obj":"Body_part"}],"attributes":[{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma9826"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma9826"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":329,"end":334},"obj":"Body_part"},{"id":"T52","span":{"begin":438,"end":442},"obj":"Body_part"},{"id":"T53","span":{"begin":443,"end":447},"obj":"Body_part"},{"id":"T54","span":{"begin":673,"end":678},"obj":"Body_part"},{"id":"T55","span":{"begin":877,"end":888},"obj":"Body_part"},{"id":"T56","span":{"begin":877,"end":882},"obj":"Body_part"},{"id":"T57","span":{"begin":896,"end":907},"obj":"Body_part"},{"id":"T58","span":{"begin":1145,"end":1150},"obj":"Body_part"},{"id":"T59","span":{"begin":1397,"end":1408},"obj":"Body_part"},{"id":"T60","span":{"begin":1397,"end":1402},"obj":"Body_part"},{"id":"T61","span":{"begin":1416,"end":1427},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_3010752"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0003728"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A60","pred":"uberon_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A61","pred":"uberon_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/UBERON_0003728"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T33","span":{"begin":1050,"end":1058},"obj":"Disease"}],"attributes":[{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T99","span":{"begin":7,"end":8},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T100","span":{"begin":9,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T101","span":{"begin":261,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T102","span":{"begin":329,"end":334},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T103","span":{"begin":403,"end":404},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T104","span":{"begin":438,"end":442},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T105","span":{"begin":438,"end":442},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T106","span":{"begin":449,"end":450},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T107","span":{"begin":595,"end":600},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T108","span":{"begin":633,"end":634},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T109","span":{"begin":673,"end":678},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T110","span":{"begin":745,"end":746},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T111","span":{"begin":877,"end":888},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T112","span":{"begin":959,"end":961},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T113","span":{"begin":1133,"end":1134},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T114","span":{"begin":1145,"end":1150},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T115","span":{"begin":1237,"end":1238},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T116","span":{"begin":1365,"end":1370},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T117","span":{"begin":1397,"end":1408},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":470,"end":473},"obj":"Chemical"},{"id":"T39","span":{"begin":1061,"end":1073},"obj":"Chemical"},{"id":"T40","span":{"begin":1069,"end":1073},"obj":"Chemical"},{"id":"T41","span":{"begin":1189,"end":1198},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_131701"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T34","span":{"begin":98,"end":103},"obj":"Phenotype"},{"id":"T35","span":{"begin":130,"end":136},"obj":"Phenotype"},{"id":"T36","span":{"begin":138,"end":147},"obj":"Phenotype"},{"id":"T37","span":{"begin":149,"end":156},"obj":"Phenotype"},{"id":"T38","span":{"begin":162,"end":169},"obj":"Phenotype"}],"attributes":[{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0025143"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0031246"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0003326"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0012378"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-sentences","denotations":[{"id":"T72","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T73","span":{"begin":7,"end":170},"obj":"Sentence"},{"id":"T74","span":{"begin":171,"end":260},"obj":"Sentence"},{"id":"T75","span":{"begin":261,"end":328},"obj":"Sentence"},{"id":"T76","span":{"begin":329,"end":448},"obj":"Sentence"},{"id":"T77","span":{"begin":449,"end":644},"obj":"Sentence"},{"id":"T78","span":{"begin":645,"end":838},"obj":"Sentence"},{"id":"T79","span":{"begin":839,"end":971},"obj":"Sentence"},{"id":"T80","span":{"begin":972,"end":1132},"obj":"Sentence"},{"id":"T81","span":{"begin":1133,"end":1288},"obj":"Sentence"},{"id":"T82","span":{"begin":1289,"end":1450},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}

{"project":"LitCovid-PubTator","denotations":[{"id":"196","span":{"begin":21,"end":26},"obj":"Species"},{"id":"197","span":{"begin":1050,"end":1060},"obj":"Species"},{"id":"198","span":{"begin":280,"end":291},"obj":"Species"},{"id":"199","span":{"begin":462,"end":469},"obj":"Chemical"},{"id":"200","span":{"begin":98,"end":103},"obj":"Disease"},{"id":"201","span":{"begin":138,"end":147},"obj":"Disease"},{"id":"202","span":{"begin":149,"end":156},"obj":"Disease"},{"id":"203","span":{"begin":162,"end":169},"obj":"Disease"}],"attributes":[{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Tax:9606"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"Tax:2697049"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Tax:12814"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"MESH:D019788"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"MESH:D005334"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D003371"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D063806"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:D005221"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Case 4\nA 48-year-old woman working in the Wuhan Union Hospital presented with an 8-day history of fever (37–38 °C) accompanied by chills, dry cough, myalgia, and fatigue. WBC count was within the reference range, but she had increased hsCRP levels (12.2 mg/L). A search for known respiratory pathogens yielded negative findings. Chest CT imaging (January 15, 2020, Fig. 4d) led to the identification of a blurry shadow in the right lower lung lobe. A subsequent 18F-FDG PET/CT scan (January 20, 2020) revealed the presence of peripheral FDG-avid GGOs with interlobular septal thickening in both lungs (SUVmax range 3.7–9.3; Fig. 4a, b, arrows). When compared with previous chest CT results, there was evidence of disease progression as shown by a higher number of lesions, which were also characterized by an increased extent and density. There were also multiple FDG-positive lymph nodes in the mediastinum and right hilar region (SUVmax range 3.8–5.5; Fig. 4c, arrows). Real-time fluorescent polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 nucleic acid yielded negative findings in two independent measurements. A follow-up chest CT (February 1, 2020) performed after antiviral and anti-infective treatment revealed a significant improvement in the picture (Fig. 4d).\nFig. 4 Peripheral FDG-avid GGOs with interlobular septal thickening in both lungs and multiple FDG-positive lymph nodes in the mediastinum and right hilar region"}