PMC:7080035 / 5779-7210 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T37","span":{"begin":62,"end":66},"obj":"Body_part"},{"id":"T38","span":{"begin":78,"end":81},"obj":"Body_part"},{"id":"T39","span":{"begin":317,"end":323},"obj":"Body_part"},{"id":"T40","span":{"begin":461,"end":472},"obj":"Body_part"},{"id":"T41","span":{"begin":483,"end":494},"obj":"Body_part"},{"id":"T42","span":{"begin":572,"end":583},"obj":"Body_part"},{"id":"T43","span":{"begin":843,"end":848},"obj":"Body_part"},{"id":"T44","span":{"begin":927,"end":938},"obj":"Body_part"},{"id":"T45","span":{"begin":927,"end":932},"obj":"Body_part"},{"id":"T46","span":{"begin":946,"end":957},"obj":"Body_part"},{"id":"T47","span":{"begin":1340,"end":1345},"obj":"Body_part"},{"id":"T48","span":{"begin":1375,"end":1386},"obj":"Body_part"},{"id":"T49","span":{"begin":1375,"end":1380},"obj":"Body_part"},{"id":"T50","span":{"begin":1394,"end":1405},"obj":"Body_part"}],"attributes":[{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma7574"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma312401"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma9826"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma9826"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T30","span":{"begin":62,"end":66},"obj":"Body_part"},{"id":"T31","span":{"begin":78,"end":81},"obj":"Body_part"},{"id":"T32","span":{"begin":317,"end":323},"obj":"Body_part"},{"id":"T33","span":{"begin":927,"end":938},"obj":"Body_part"},{"id":"T34","span":{"begin":927,"end":932},"obj":"Body_part"},{"id":"T35","span":{"begin":946,"end":957},"obj":"Body_part"},{"id":"T36","span":{"begin":1375,"end":1386},"obj":"Body_part"},{"id":"T37","span":{"begin":1375,"end":1380},"obj":"Body_part"},{"id":"T38","span":{"begin":1394,"end":1405},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0002228"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0007311"},{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0003728"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0003728"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"T29","span":{"begin":381,"end":391},"obj":"Disease"},{"id":"T30","span":{"begin":1040,"end":1048},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005315"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0003785"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T63","span":{"begin":7,"end":8},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T64","span":{"begin":30,"end":31},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T65","span":{"begin":62,"end":66},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T66","span":{"begin":62,"end":66},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T67","span":{"begin":78,"end":81},"obj":"http://purl.obolibrary.org/obo/UBERON_0002228"},{"id":"T68","span":{"begin":119,"end":120},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T69","span":{"begin":359,"end":366},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T70","span":{"begin":572,"end":583},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T71","span":{"begin":661,"end":662},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T72","span":{"begin":843,"end":848},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T73","span":{"begin":877,"end":879},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T74","span":{"begin":881,"end":882},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T75","span":{"begin":927,"end":938},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T76","span":{"begin":1064,"end":1075},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T77","span":{"begin":1340,"end":1345},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T78","span":{"begin":1375,"end":1386},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T28","span":{"begin":737,"end":740},"obj":"Chemical"},{"id":"T29","span":{"begin":1051,"end":1063},"obj":"Chemical"},{"id":"T30","span":{"begin":1059,"end":1063},"obj":"Chemical"},{"id":"T31","span":{"begin":1114,"end":1117},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_131701"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_131701"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T27","span":{"begin":184,"end":202},"obj":"Phenotype"},{"id":"T28","span":{"begin":284,"end":291},"obj":"Phenotype"},{"id":"T29","span":{"begin":296,"end":305},"obj":"Phenotype"},{"id":"T30","span":{"begin":307,"end":312},"obj":"Phenotype"},{"id":"T31","span":{"begin":381,"end":391},"obj":"Phenotype"}],"attributes":[{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0001954"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0012378"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0002321"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0001882"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T54","span":{"begin":7,"end":306},"obj":"Sentence"},{"id":"T55","span":{"begin":307,"end":347},"obj":"Sentence"},{"id":"T56","span":{"begin":348,"end":517},"obj":"Sentence"},{"id":"T57","span":{"begin":518,"end":728},"obj":"Sentence"},{"id":"T58","span":{"begin":729,"end":892},"obj":"Sentence"},{"id":"T59","span":{"begin":893,"end":1024},"obj":"Sentence"},{"id":"T60","span":{"begin":1025,"end":1090},"obj":"Sentence"},{"id":"T61","span":{"begin":1091,"end":1269},"obj":"Sentence"},{"id":"T62","span":{"begin":1270,"end":1431},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}

{"project":"LitCovid-PubTator","denotations":[{"id":"164","span":{"begin":1040,"end":1050},"obj":"Species"},{"id":"165","span":{"begin":680,"end":691},"obj":"Species"},{"id":"166","span":{"begin":729,"end":736},"obj":"Chemical"},{"id":"167","span":{"begin":1106,"end":1113},"obj":"Chemical"},{"id":"168","span":{"begin":78,"end":108},"obj":"Disease"},{"id":"169","span":{"begin":197,"end":202},"obj":"Disease"},{"id":"170","span":{"begin":284,"end":291},"obj":"Disease"},{"id":"171","span":{"begin":296,"end":305},"obj":"Disease"},{"id":"172","span":{"begin":307,"end":312},"obj":"Disease"},{"id":"173","span":{"begin":381,"end":391},"obj":"Disease"}],"attributes":[{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Tax:2697049"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Tax:12814"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"MESH:D019788"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"MESH:D019788"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"MESH:D012253"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"MESH:D005334"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"MESH:D005221"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"MESH:D004244"},{"id":"A172","pred":"tao:has_database_id","subj":"172","obj":"MESH:D003371"},{"id":"A173","pred":"tao:has_database_id","subj":"173","obj":"MESH:D007970"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Case 2\nA 56-year-old man with a recent history of surgery for lung repair and rib fracture internal fixation following a traumatic event presented to hospital with an 8-day history of intermittent fever (up to 39.1 °C, more frequent in early morning and the afternoon) accompanied by fatigue and dizziness. Cough and sputum production were absent. Laboratory testing revealed mild leukopenia (WBC count 3.33 × 109/L; reference range 3.5–9.5 × 109/L) with 75.5% neutrophils and 17.5% lymphocytes (normal range 20–40%). Inflammatory indices, including hsCRP (23.6 mg/L) and erythrocyte sedimentation rate (73 mm/h; reference range \u003c 15 mm/h), were increased, but a search for known respiratory pathogens yielded negative findings. 18F-FDG PET/CT imaging (January 13, 2020) revealed multiple FDG-positive GGOs and consolidative opacities in both lungs (SUVmax range 1.8–7.9; Fig. 2a, b, arrows). There were also multiple FDG-avid lymph nodes in the mediastinum and the subclavian region (SUVmax range 4.1–7.0; Fig. 2c, arrows). Unfortunately, SARS-CoV-2 nucleic acid testing was not performed. The lesions on 18F-FDG PET/CT were smaller than those detected on previous CT imaging (January 7, 2020) and regressed further after treatment (January 21, 2020; Fig. 2d, arrows).\nFig. 2 Multiple FDG-positive GGOs and consolidative opacities in both lungs as well as multiple FDG-avid lymph nodes in the mediastinum and the subclavian region"}