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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":1453,"end":1455},"obj":"https://glytoucan.org/Structures/Glycans/G04616ST"},{"id":"T2","span":{"begin":1611,"end":1613},"obj":"https://glytoucan.org/Structures/Glycans/G04616ST"},{"id":"T3","span":{"begin":1983,"end":1985},"obj":"https://glytoucan.org/Structures/Glycans/G04616ST"}],"text":"In general, the identification of pulmonary GGOs or patients presenting with persistent fever should prompt additional diagnostic testing for differential diagnosis—including 18F-FDG PET/CT imaging. Here, we report the 18F-FDG PET/CT findings from four patients who were admitted to the Wuhan Union Hospital with lung GGOs and fever between January 13 and January 20, 2020—when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings (Table 1) strongly suggested a diagnosis of COVID-19.\nTable 1 General characteristics and PET/CT findings of four cases with COVID-19\nPatient number 1 2 3 4\nSex Man Man Woman Woman\nAge, years 57 56 61 48\nClinical symptoms Fever, sore throat Fever, fatigue, dizziness Back pain, dry cough Fever, chill, dry cough, myalgia, and fatigue\nHistory of staying in Wuhan Yes Yes Yes Yes\nWBC (× 109/L) (reference range 3.5–9.5 × 109/L) Normal 3.33 3.47 Normal\nLymphocytes (%) (reference range 20–40%) Normal 17.5% Normal Normal\nHsCRP (mg/L) (reference range 0–5 mg/L) 6.65 23.6 Not available 12.2\nRespiratory pathogens* Negative Negative Not available Negative\nPET/CT findings Number of affected lobes 2 (RUL, LLL) 5 (all lobes) 3 (RUL, RLL, LLL) 3 (RML, RLL, LLL)\nLung CT features GGO GGO and consolidative opacities GGO GGO with interlobular septal thickening\nSUVmax 4.6 7.9 12.2 9.3\nLN involvement Absent Right subclavian region, mediastinum Right supraclavicular region, mediastinum Right subclavian region, mediastinum, right hilar region\nLN SUVmax – 7 5.4 5.5\nConcomitant diseases** Absent Absent Absent Absent\n*The following respiratory pathogens were investigated: Mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, and Coxsackie B-virus specific IgM\n**Including malignancies and other infectious diseases\nWBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; LN, lymph node; RUL, right upper lobe; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe; GGO, ground-glass opacities; SUV, standardized uptake value"}

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T12","span":{"begin":382,"end":390},"obj":"Disease"},{"id":"T13","span":{"begin":621,"end":629},"obj":"Disease"},{"id":"T14","span":{"begin":702,"end":710},"obj":"Disease"},{"id":"T15","span":{"begin":806,"end":817},"obj":"Disease"},{"id":"T16","span":{"begin":1453,"end":1455},"obj":"Disease"},{"id":"T17","span":{"begin":1611,"end":1613},"obj":"Disease"},{"id":"T18","span":{"begin":1740,"end":1761},"obj":"Disease"},{"id":"T19","span":{"begin":1763,"end":1783},"obj":"Disease"},{"id":"T20","span":{"begin":1896,"end":1906},"obj":"Disease"},{"id":"T21","span":{"begin":1983,"end":1985},"obj":"Disease"}],"attributes":[{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0002258"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0002486"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0002486"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005867"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0025598"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0002486"}],"text":"In general, the identification of pulmonary GGOs or patients presenting with persistent fever should prompt additional diagnostic testing for differential diagnosis—including 18F-FDG PET/CT imaging. Here, we report the 18F-FDG PET/CT findings from four patients who were admitted to the Wuhan Union Hospital with lung GGOs and fever between January 13 and January 20, 2020—when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings (Table 1) strongly suggested a diagnosis of COVID-19.\nTable 1 General characteristics and PET/CT findings of four cases with COVID-19\nPatient number 1 2 3 4\nSex Man Man Woman Woman\nAge, years 57 56 61 48\nClinical symptoms Fever, sore throat Fever, fatigue, dizziness Back pain, dry cough Fever, chill, dry cough, myalgia, and fatigue\nHistory of staying in Wuhan Yes Yes Yes Yes\nWBC (× 109/L) (reference range 3.5–9.5 × 109/L) Normal 3.33 3.47 Normal\nLymphocytes (%) (reference range 20–40%) Normal 17.5% Normal Normal\nHsCRP (mg/L) (reference range 0–5 mg/L) 6.65 23.6 Not available 12.2\nRespiratory pathogens* Negative Negative Not available Negative\nPET/CT findings Number of affected lobes 2 (RUL, LLL) 5 (all lobes) 3 (RUL, RLL, LLL) 3 (RML, RLL, LLL)\nLung CT features GGO GGO and consolidative opacities GGO GGO with interlobular septal thickening\nSUVmax 4.6 7.9 12.2 9.3\nLN involvement Absent Right subclavian region, mediastinum Right supraclavicular region, mediastinum Right subclavian region, mediastinum, right hilar region\nLN SUVmax – 7 5.4 5.5\nConcomitant diseases** Absent Absent Absent Absent\n*The following respiratory pathogens were investigated: Mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, and Coxsackie B-virus specific IgM\n**Including malignancies and other infectious diseases\nWBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; LN, lymph node; RUL, right upper lobe; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe; GGO, ground-glass opacities; SUV, standardized uptake value"}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T22","span":{"begin":130,"end":137},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T23","span":{"begin":313,"end":317},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T24","span":{"begin":313,"end":317},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T25","span":{"begin":431,"end":436},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T26","span":{"begin":462,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27","span":{"begin":606,"end":607},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":730,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T29","span":{"begin":778,"end":780},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T30","span":{"begin":1332,"end":1336},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T31","span":{"begin":1332,"end":1336},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T32","span":{"begin":1819,"end":1824},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T33","span":{"begin":1840,"end":1841},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T34","span":{"begin":1842,"end":1847},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T35","span":{"begin":1927,"end":1932},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T36","span":{"begin":1933,"end":1937},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T37","span":{"begin":1987,"end":1997},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"}],"text":"In general, the identification of pulmonary GGOs or patients presenting with persistent fever should prompt additional diagnostic testing for differential diagnosis—including 18F-FDG PET/CT imaging. Here, we report the 18F-FDG PET/CT findings from four patients who were admitted to the Wuhan Union Hospital with lung GGOs and fever between January 13 and January 20, 2020—when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings (Table 1) strongly suggested a diagnosis of COVID-19.\nTable 1 General characteristics and PET/CT findings of four cases with COVID-19\nPatient number 1 2 3 4\nSex Man Man Woman Woman\nAge, years 57 56 61 48\nClinical symptoms Fever, sore throat Fever, fatigue, dizziness Back pain, dry cough Fever, chill, dry cough, myalgia, and fatigue\nHistory of staying in Wuhan Yes Yes Yes Yes\nWBC (× 109/L) (reference range 3.5–9.5 × 109/L) Normal 3.33 3.47 Normal\nLymphocytes (%) (reference range 20–40%) Normal 17.5% Normal Normal\nHsCRP (mg/L) (reference range 0–5 mg/L) 6.65 23.6 Not available 12.2\nRespiratory pathogens* Negative Negative Not available Negative\nPET/CT findings Number of affected lobes 2 (RUL, LLL) 5 (all lobes) 3 (RUL, RLL, LLL) 3 (RML, RLL, LLL)\nLung CT features GGO GGO and consolidative opacities GGO GGO with interlobular septal thickening\nSUVmax 4.6 7.9 12.2 9.3\nLN involvement Absent Right subclavian region, mediastinum Right supraclavicular region, mediastinum Right subclavian region, mediastinum, right hilar region\nLN SUVmax – 7 5.4 5.5\nConcomitant diseases** Absent Absent Absent Absent\n*The following respiratory pathogens were investigated: Mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, and Coxsackie B-virus specific IgM\n**Including malignancies and other infectious diseases\nWBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; LN, lymph node; RUL, right upper lobe; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe; GGO, ground-glass opacities; SUV, standardized uptake value"}

LitCovid-PD-CHEBI

LitCovid-PD-HP

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":2160,"end":2166},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T5","span":{"begin":2160,"end":2166},"obj":"http://purl.obolibrary.org/obo/GO_0098657"}],"text":"In general, the identification of pulmonary GGOs or patients presenting with persistent fever should prompt additional diagnostic testing for differential diagnosis—including 18F-FDG PET/CT imaging. Here, we report the 18F-FDG PET/CT findings from four patients who were admitted to the Wuhan Union Hospital with lung GGOs and fever between January 13 and January 20, 2020—when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings (Table 1) strongly suggested a diagnosis of COVID-19.\nTable 1 General characteristics and PET/CT findings of four cases with COVID-19\nPatient number 1 2 3 4\nSex Man Man Woman Woman\nAge, years 57 56 61 48\nClinical symptoms Fever, sore throat Fever, fatigue, dizziness Back pain, dry cough Fever, chill, dry cough, myalgia, and fatigue\nHistory of staying in Wuhan Yes Yes Yes Yes\nWBC (× 109/L) (reference range 3.5–9.5 × 109/L) Normal 3.33 3.47 Normal\nLymphocytes (%) (reference range 20–40%) Normal 17.5% Normal Normal\nHsCRP (mg/L) (reference range 0–5 mg/L) 6.65 23.6 Not available 12.2\nRespiratory pathogens* Negative Negative Not available Negative\nPET/CT findings Number of affected lobes 2 (RUL, LLL) 5 (all lobes) 3 (RUL, RLL, LLL) 3 (RML, RLL, LLL)\nLung CT features GGO GGO and consolidative opacities GGO GGO with interlobular septal thickening\nSUVmax 4.6 7.9 12.2 9.3\nLN involvement Absent Right subclavian region, mediastinum Right supraclavicular region, mediastinum Right subclavian region, mediastinum, right hilar region\nLN SUVmax – 7 5.4 5.5\nConcomitant diseases** Absent Absent Absent Absent\n*The following respiratory pathogens were investigated: Mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, and Coxsackie B-virus specific IgM\n**Including malignancies and other infectious diseases\nWBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; LN, lymph node; RUL, right upper lobe; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe; GGO, ground-glass opacities; SUV, standardized uptake value"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T21","span":{"begin":0,"end":198},"obj":"Sentence"},{"id":"T22","span":{"begin":199,"end":461},"obj":"Sentence"},{"id":"T23","span":{"begin":462,"end":630},"obj":"Sentence"},{"id":"T24","span":{"begin":631,"end":710},"obj":"Sentence"},{"id":"T25","span":{"begin":711,"end":733},"obj":"Sentence"},{"id":"T26","span":{"begin":734,"end":757},"obj":"Sentence"},{"id":"T27","span":{"begin":758,"end":780},"obj":"Sentence"},{"id":"T28","span":{"begin":781,"end":910},"obj":"Sentence"},{"id":"T29","span":{"begin":911,"end":954},"obj":"Sentence"},{"id":"T30","span":{"begin":955,"end":1026},"obj":"Sentence"},{"id":"T31","span":{"begin":1027,"end":1094},"obj":"Sentence"},{"id":"T32","span":{"begin":1095,"end":1163},"obj":"Sentence"},{"id":"T33","span":{"begin":1164,"end":1227},"obj":"Sentence"},{"id":"T34","span":{"begin":1228,"end":1331},"obj":"Sentence"},{"id":"T35","span":{"begin":1332,"end":1428},"obj":"Sentence"},{"id":"T36","span":{"begin":1429,"end":1452},"obj":"Sentence"},{"id":"T37","span":{"begin":1453,"end":1610},"obj":"Sentence"},{"id":"T38","span":{"begin":1611,"end":1632},"obj":"Sentence"},{"id":"T39","span":{"begin":1633,"end":1683},"obj":"Sentence"},{"id":"T40","span":{"begin":1684,"end":1739},"obj":"Sentence"},{"id":"T41","span":{"begin":1740,"end":1860},"obj":"Sentence"},{"id":"T42","span":{"begin":1861,"end":1915},"obj":"Sentence"},{"id":"T43","span":{"begin":1916,"end":2172},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In general, the identification of pulmonary GGOs or patients presenting with persistent fever should prompt additional diagnostic testing for differential diagnosis—including 18F-FDG PET/CT imaging. Here, we report the 18F-FDG PET/CT findings from four patients who were admitted to the Wuhan Union Hospital with lung GGOs and fever between January 13 and January 20, 2020—when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings (Table 1) strongly suggested a diagnosis of COVID-19.\nTable 1 General characteristics and PET/CT findings of four cases with COVID-19\nPatient number 1 2 3 4\nSex Man Man Woman Woman\nAge, years 57 56 61 48\nClinical symptoms Fever, sore throat Fever, fatigue, dizziness Back pain, dry cough Fever, chill, dry cough, myalgia, and fatigue\nHistory of staying in Wuhan Yes Yes Yes Yes\nWBC (× 109/L) (reference range 3.5–9.5 × 109/L) Normal 3.33 3.47 Normal\nLymphocytes (%) (reference range 20–40%) Normal 17.5% Normal Normal\nHsCRP (mg/L) (reference range 0–5 mg/L) 6.65 23.6 Not available 12.2\nRespiratory pathogens* Negative Negative Not available Negative\nPET/CT findings Number of affected lobes 2 (RUL, LLL) 5 (all lobes) 3 (RUL, RLL, LLL) 3 (RML, RLL, LLL)\nLung CT features GGO GGO and consolidative opacities GGO GGO with interlobular septal thickening\nSUVmax 4.6 7.9 12.2 9.3\nLN involvement Absent Right subclavian region, mediastinum Right supraclavicular region, mediastinum Right subclavian region, mediastinum, right hilar region\nLN SUVmax – 7 5.4 5.5\nConcomitant diseases** Absent Absent Absent Absent\n*The following respiratory pathogens were investigated: Mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, and Coxsackie B-virus specific IgM\n**Including malignancies and other infectious diseases\nWBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; LN, lymph node; RUL, right upper lobe; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe; GGO, ground-glass opacities; SUV, standardized uptake value"}

LitCovid-PubTator

PMC:7080035 / 2425-4597 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7080035 / 2425-4597 JSON TXT