PMC:7079563 / 1900-9149
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7079563","sourcedb":"PMC","sourceid":"7079563","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7079563","text":"1 Emergence and epidemic of pneumonias caused by 2019-nCoV\n\n1.1 Pathogen identification and transmission of pneumonia\nOn 31th December 2019, the first pneumonia case of unknown etiology was reported in Wuhan City, Hubei Province, China. In order to identify the etiology, a number of possible etiological agents were ruled out, including the Severe acute respiratory syndrome coronavirus (SARS-CoV), the Middle-East respiratory syndrome coronavirus (MERS-CoV), avian influenza virus, and other common respiratory pathogens. Finally, a new coronavirus, temporally named 2019-nCoV, was identified to be the pathogen responsible for disease, and it was announced by World Health Organization (WHO) on 12th January [3]. As of January 11, 2020, 41 pneumonia cases were diagnosed, including seven severe cases and one death [2]. At that time, there was no evidence of person-to-person transmission according to the scientific literature. The first “super-spreading” event became a hallmark of the epidemiology of the disease. On January 20, 2020, in epidemiological investigations, two local infections in patients who were infected by 2019-nCoV without physical visits to Wuhan were reported in Guangdong Province, which confirmed the occurrence of human-to-human transmission [4]. Then, 14 medical staff infected by 2019-nCoV from patients further confirmed the human-to-human contagion [5]. On 21th January 2020, WHO announced that 2019-nCoV was possibly sustained through human-to-human transmission, warning the public to take self-protection measures [3]. The first of many cases, this disease was rapidly shown to cause an epidemic [6]. Due to the high transmissibility of 2019-nCoV, the Chinese government has taken quick action and various measures to deal with the epidemic, trying to prevent spread of the outbreak and to treat patients. Researchers put much effort to understand the origin and pathophysiology of this novel coronavirus, and have been testing multiple drugs to screen effective therapy.\n\n1.2 Current situation of the epidemic\nUntil February 6, 2020, confirmed 2019-nCoV pneumonia cases were increasing with worrisome speed in China. As of 5th February, there were 24,377 cases confirmed in mainland China, including 492 deaths, 3219 severe cases, and 901 cured cases [6]. The fatality rate was about 2%. In addition, 175 cases of 2019-nCoV infection were confirmed in 24 other countries around the world. The typical events during the 2019-nCoV outbreak are summarized in Table 1 . The period from the end of December 2019 to January 2020 was the “Spring Festival travel rush” time in China. Although the government issued an order to control the flow of people, the disease spread rapidly to other cities because of asymptomatic carriers [[7], [8], [9]].\nTable 1 Key events of 2019-nCoV.\nDate Key events\n31 December 2019 The Health Commission of Hubei province, China, first announced a cluster of unexplained cases of pneumonia.\n3 January 2020 A total of 44 patients (11 are severely ill, while the remaining 33 patients are in stable condition.) with pneumonia of unknown etiology have been reported to WHO by the national authorities in China.\n5 January 2020 The WHO published a document detailing 44 patients had “pneumonia of unknown etiology”, with 121 close contacts under surveillance.\n8 January 2020 The genetic sequencing demonstrated that the novel coronavirus is the potential causative organism.\n11 January 2020 41 patients have been diagnosed to have infection of the novel coronavirus, with 763 close contacts, 7 severe cases and the first death.\n12 January 2020 The virus was tentatively named by WHO as the 2019 novel coronavirus (2019-nCoV).\n13 January 2020 The first imported case of 2019-nCoV was found in Thailand. This is the first infected person diagnosed outside China. The patient is a 61-year-old Chinese woman living in Wuhan City, Hubei Province, China.\n16 January 2020 The first case reported in Japan. This is the second confirmed case of 2019-nCoV that has been detected outside of China. The person travelled to Wuhan, China.\n19 January 2020 The first case reported in Korea. The patient was a Chinese woman who flew from Wuhan to Incheon International Airport. Four other suspected patients were being examined. Furthermore, the first case reported in Shenzhen, China.\n20 January 2020 Two local infections in the Chinese province of Guangdong with no direct visit to Wuhan were the first confirmed the occurrence of human-to-human transmission through epidemiological investigation. And the first case reported in Shanghai, China.\n21 January 2020 15 health-care workers infected with the 2019-nCoV in Wuhan. Zhejiang Province, Henan Province, Sichuan Province and Taiwa confirmed the first case of 2019-nCoV, respectively. The WHO announced that there was possible sustained human to-human transmission.\n22–23 January 2020 17 death in Hubei Province. America and Macao and Many provinces confirmed the first case of 2019-nCoV. Such as Shandong Province, Yunnan Province, Hunan Province, America, Macao, Anhui Province, Fujian Province, Guizhou Province, Shanxi Province, Ningxia Autonomous Region and Hebei Province reported the first case of 2019-nCoV, respectively.\n23 January 2020 the local government in Wuhan announced the suspension of public transportation, with closure of airports, railway stations, and highways\n24 January 2020 Zhejiang and Shanghai’s first patients diagnosed with 2019-nCoV recover.\n5 February 2020 The confirmed pneumonia cases are increasing in 34 provinces, municipalities, and special administrative regions in China. 24,377 cases of 2019-nCoV confirmed in China, including 492 deaths, 3219 serious, and 901 cured. 175 cases of infection were confirmed in 24 other cities around the world.\n\n1.3 Preventive measures\nTo deal with the 2019-nCoV epidemic, the central and local governments of China took a series of drastic measures. First of all, Chinese health authorities conducted an immediate investigation to characterize and control the disease, including isolation of suspected patients, monitoring of contact clinical status of patients, and developing diagnostic and treatment procedures [5]. In addition, on January 23, 2020, the local government of Wuhan announced the suspension of public transportation, closing airports, railway stations, and highways in the city, in order to prevent further disease transmission [10]. Subsequently, most provinces in China claimed “Level I Emergency Response” by taking a series of measures such as suspending public transportation and setting up community quarantines. Particularly, the list of the first-level designated hospitals was announced, and epidemic prevention training for primary medical staff was started. Since fever is one of typical clinical symptoms of the infection, temperature detection of incoming and outgoing personnel was implemented comprehensively in railway stations, passenger stations and other public places, in order to screen suspected cases as early as possible. In addition, many other compulsory measures limiting population mobility, such as cancellation of mass gatherings, school closures, work-from-home arrangements, was taken to reduce within-population contact 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