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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7077191","sourcedb":"PMC","sourceid":"7077191","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7077191","text":"Many studies have been performed to study the pathogenesis of SARS-CoV [94,95,96]. The spike (S) protein and N protein confer stability to the viral particle [97]. The N protein is a structural protein involved in virion assembly, and plays a pivotal role in virus transcription and assembly efficiency [97]. S protein can bind to the cellular receptors of sensitive cells and mediate infection of their target cells, after which it begins to replicate in the cytoplasm [98]. SARS-CoV mainly targets the lungs, immune organs, and small systemic blood vessels and causes systemic vasculitis and decrease of immune function [99]. 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