PMC:7074424 / 17316-18133 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"412","span":{"begin":788,"end":792},"obj":"Gene"},{"id":"413","span":{"begin":100,"end":104},"obj":"Species"},{"id":"414","span":{"begin":561,"end":564},"obj":"Species"},{"id":"415","span":{"begin":761,"end":770},"obj":"Species"},{"id":"416","span":{"begin":793,"end":796},"obj":"Species"},{"id":"417","span":{"begin":676,"end":699},"obj":"Chemical"}],"attributes":[{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"Gene:54938"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"Tax:11118"},{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"Tax:11118"},{"id":"A415","pred":"tao:has_database_id","subj":"415","obj":"Tax:9606"},{"id":"A416","pred":"tao:has_database_id","subj":"416","obj":"Tax:11118"},{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"MESH:C057360"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"2_test","denotations":[{"id":"32201449-25726972-47217082","span":{"begin":96,"end":98},"obj":"25726972"},{"id":"32201449-17182690-47217083","span":{"begin":184,"end":186},"obj":"17182690"},{"id":"32201449-15288785-47217084","span":{"begin":260,"end":262},"obj":"15288785"},{"id":"32201449-25726972-47217085","span":{"begin":475,"end":477},"obj":"25726972"},{"id":"32201449-25726972-47217086","span":{"begin":522,"end":524},"obj":"25726972"},{"id":"32201449-21524776-47217087","span":{"begin":597,"end":599},"obj":"21524776"},{"id":"32201449-19593379-47217088","span":{"begin":814,"end":816},"obj":"19593379"},{"id":"T4056","span":{"begin":96,"end":98},"obj":"25726972"},{"id":"T73604","span":{"begin":184,"end":186},"obj":"17182690"},{"id":"T72058","span":{"begin":260,"end":262},"obj":"15288785"},{"id":"T3918","span":{"begin":475,"end":477},"obj":"25726972"},{"id":"T37907","span":{"begin":522,"end":524},"obj":"25726972"},{"id":"T86136","span":{"begin":597,"end":599},"obj":"21524776"},{"id":"T70012","span":{"begin":814,"end":816},"obj":"19593379"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T518","span":{"begin":4,"end":13},"obj":"PG_2"},{"id":"T517","span":{"begin":36,"end":41},"obj":"GO:0035262;NCBITaxon:10239"},{"id":"T516","span":{"begin":42,"end":55},"obj":"GO:0009653"},{"id":"T515","span":{"begin":113,"end":122},"obj":"PG_2"},{"id":"T514","span":{"begin":134,"end":139},"obj":"NCBITaxon:10239"},{"id":"T513","span":{"begin":190,"end":208},"obj":"GO:0051260"},{"id":"T512","span":{"begin":246,"end":249},"obj":"CHEBI:24870;CHEBI:24870"},{"id":"T511","span":{"begin":297,"end":300},"obj":"CHEBI:24870;CHEBI:24870"},{"id":"T510","span":{"begin":364,"end":373},"obj":"PG_2"},{"id":"T509","span":{"begin":406,"end":419},"obj":"GO:0005622"},{"id":"T508","span":{"begin":433,"end":442},"obj":"GO:0065007"},{"id":"T507","span":{"begin":479,"end":488},"obj":"PG_2"},{"id":"T506","span":{"begin":526,"end":535},"obj":"PG_2"},{"id":"T505","span":{"begin":561,"end":573},"obj":"GO:0050817"},{"id":"T504","span":{"begin":618,"end":627},"obj":"PG_2"},{"id":"T503","span":{"begin":645,"end":647},"obj":"GO:0005783"},{"id":"T502","span":{"begin":652,"end":662},"obj":"GO:0005794"},{"id":"T501","span":{"begin":676,"end":689},"obj":"CHEBI:64390;CHEBI:64390"},{"id":"T500","span":{"begin":690,"end":699},"obj":"CHEBI:2639;CHEBI:2639"},{"id":"T499","span":{"begin":712,"end":721},"obj":"PG_2"},{"id":"T498","span":{"begin":733,"end":736},"obj":"CHEBI:24870;CHEBI:24870"},{"id":"T497","span":{"begin":761,"end":770},"obj":"NCBITaxon:40674"},{"id":"T496","span":{"begin":777,"end":787},"obj":"GO:0010467"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T168","span":{"begin":6,"end":13},"obj":"Body_part"},{"id":"T169","span":{"begin":115,"end":122},"obj":"Body_part"},{"id":"T170","span":{"begin":211,"end":219},"obj":"Body_part"},{"id":"T171","span":{"begin":366,"end":373},"obj":"Body_part"},{"id":"T172","span":{"begin":420,"end":428},"obj":"Body_part"},{"id":"T173","span":{"begin":465,"end":473},"obj":"Body_part"},{"id":"T174","span":{"begin":481,"end":488},"obj":"Body_part"},{"id":"T175","span":{"begin":528,"end":535},"obj":"Body_part"},{"id":"T176","span":{"begin":620,"end":627},"obj":"Body_part"},{"id":"T177","span":{"begin":645,"end":647},"obj":"Body_part"},{"id":"T178","span":{"begin":658,"end":670},"obj":"Body_part"},{"id":"T179","span":{"begin":714,"end":721},"obj":"Body_part"},{"id":"T180","span":{"begin":771,"end":776},"obj":"Body_part"},{"id":"T181","span":{"begin":805,"end":812},"obj":"Body_part"}],"attributes":[{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma7153"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T195","span":{"begin":14,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T196","span":{"begin":18,"end":19},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T197","span":{"begin":447,"end":455},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T198","span":{"begin":502,"end":503},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T199","span":{"begin":536,"end":539},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T200","span":{"begin":745,"end":753},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T201","span":{"begin":771,"end":776},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T169","span":{"begin":6,"end":13},"obj":"Chemical"},{"id":"T170","span":{"begin":115,"end":122},"obj":"Chemical"},{"id":"T171","span":{"begin":211,"end":219},"obj":"Chemical"},{"id":"T172","span":{"begin":246,"end":249},"obj":"Chemical"},{"id":"T173","span":{"begin":297,"end":300},"obj":"Chemical"},{"id":"T174","span":{"begin":366,"end":373},"obj":"Chemical"},{"id":"T175","span":{"begin":420,"end":428},"obj":"Chemical"},{"id":"T176","span":{"begin":465,"end":473},"obj":"Chemical"},{"id":"T177","span":{"begin":481,"end":488},"obj":"Chemical"},{"id":"T178","span":{"begin":504,"end":520},"obj":"Chemical"},{"id":"T179","span":{"begin":528,"end":535},"obj":"Chemical"},{"id":"T180","span":{"begin":620,"end":627},"obj":"Chemical"},{"id":"T181","span":{"begin":676,"end":699},"obj":"Chemical"},{"id":"T182","span":{"begin":690,"end":699},"obj":"Chemical"},{"id":"T183","span":{"begin":714,"end":721},"obj":"Chemical"},{"id":"T184","span":{"begin":733,"end":736},"obj":"Chemical"},{"id":"T185","span":{"begin":805,"end":812},"obj":"Chemical"}],"attributes":[{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A170","pred":"chebi_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A171","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A173","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_72316"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A180","pred":"chebi_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A181","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_76400"},{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_2639"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T31","span":{"begin":42,"end":55},"obj":"http://purl.obolibrary.org/obo/GO_0009653"},{"id":"T32","span":{"begin":233,"end":242},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T33","span":{"begin":246,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0022831"},{"id":"T34","span":{"begin":297,"end":309},"obj":"http://purl.obolibrary.org/obo/GO_0022831"},{"id":"T35","span":{"begin":504,"end":513},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T36","span":{"begin":504,"end":513},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T37","span":{"begin":578,"end":585},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T38","span":{"begin":586,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T39","span":{"begin":733,"end":753},"obj":"http://purl.obolibrary.org/obo/GO_0005216"},{"id":"T40","span":{"begin":737,"end":753},"obj":"http://purl.obolibrary.org/obo/GO_0015267"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T112","span":{"begin":0,"end":329},"obj":"Sentence"},{"id":"T113","span":{"begin":330,"end":817},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The E protein has a special role in viral morphogenesis, especially during assembly and egress.[59] CoVs lacking E protein show lower viral titer, immature, and inefficient progenies.[5860] Oligomerization of E proteins leads to the formation of ion channels.[61] However, the importance of these ion channels is still not clear. Many other studies infer that the E protein acts in coordination with other intracellular proteins and modulates the activity of those proteins.[59] E protein also acts as a virulence factor.[59] E protein has an important role in CoV assembly and budding formation.[24] Apart from this, E protein found around the ER and Golgi body regions.[60] Hexamethylene amiloride blocks this E protein-associated ion channel activity in the mammalian cells expressing SERS-CoV envelop protein.[62]"}