PMC:7074424 / 12723-13372 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"285","span":{"begin":292,"end":296},"obj":"Gene"},{"id":"287","span":{"begin":142,"end":145},"obj":"Species"},{"id":"288","span":{"begin":308,"end":316},"obj":"Species"},{"id":"289","span":{"begin":337,"end":345},"obj":"Species"},{"id":"290","span":{"begin":431,"end":434},"obj":"Species"},{"id":"291","span":{"begin":641,"end":644},"obj":"Species"}],"attributes":[{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:59272"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Tax:11118"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Tax:694009"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Tax:1335626"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"Tax:11118"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"Tax:11118"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"2_test","denotations":[{"id":"32201449-22816037-47217045","span":{"begin":147,"end":148},"obj":"22816037"},{"id":"32201449-27578435-47217046","span":{"begin":222,"end":224},"obj":"27578435"},{"id":"32201449-27578435-47217047","span":{"begin":560,"end":562},"obj":"27578435"},{"id":"32201449-27578435-47217048","span":{"begin":646,"end":648},"obj":"27578435"},{"id":"T90917","span":{"begin":147,"end":148},"obj":"22816037"},{"id":"T51025","span":{"begin":222,"end":224},"obj":"27578435"},{"id":"T33030","span":{"begin":560,"end":562},"obj":"27578435"},{"id":"T44754","span":{"begin":646,"end":648},"obj":"27578435"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T481","span":{"begin":195,"end":200},"obj":"NCBITaxon:10239;GO:0035376"},{"id":"T480","span":{"begin":201,"end":206},"obj":"GO:0035376"},{"id":"T479","span":{"begin":262,"end":268},"obj":"SO:0000417"},{"id":"T478","span":{"begin":292,"end":296},"obj":"G_3;PG_10;PR:000003622"},{"id":"T477","span":{"begin":308,"end":316},"obj":"SP_10"},{"id":"T476","span":{"begin":337,"end":345},"obj":"SP_9"},{"id":"T475","span":{"begin":382,"end":391},"obj":"GO:0061025"},{"id":"T474","span":{"begin":396,"end":400},"obj":"GO:0018995"},{"id":"T473","span":{"begin":405,"end":410},"obj":"NCBITaxon:10239;GO:0036338"},{"id":"T472","span":{"begin":411,"end":420},"obj":"GO:0036338"},{"id":"T471","span":{"begin":431,"end":434},"obj":"NCBITaxon:11886"},{"id":"T470","span":{"begin":440,"end":446},"obj":"SO:0001026"},{"id":"T469","span":{"begin":539,"end":543},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T468","span":{"begin":601,"end":607},"obj":"UBERON:0002405;GO:0006955"},{"id":"T467","span":{"begin":608,"end":619},"obj":"GO:0006955"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T113","span":{"begin":6,"end":14},"obj":"Body_part"},{"id":"T114","span":{"begin":160,"end":167},"obj":"Body_part"},{"id":"T115","span":{"begin":362,"end":372},"obj":"Body_part"},{"id":"T116","span":{"begin":436,"end":439},"obj":"Body_part"},{"id":"T117","span":{"begin":440,"end":446},"obj":"Body_part"},{"id":"T118","span":{"begin":472,"end":477},"obj":"Body_part"},{"id":"T119","span":{"begin":494,"end":502},"obj":"Body_part"},{"id":"T120","span":{"begin":574,"end":581},"obj":"Body_part"},{"id":"T121","span":{"begin":629,"end":633},"obj":"Body_part"}],"attributes":[{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma256627"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T68","span":{"begin":308,"end":316},"obj":"Disease"},{"id":"T69","span":{"begin":308,"end":312},"obj":"Disease"}],"attributes":[{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T117","span":{"begin":107,"end":108},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T118","span":{"begin":195,"end":200},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T119","span":{"begin":259,"end":261},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T120","span":{"begin":362,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T121","span":{"begin":362,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T122","span":{"begin":411,"end":420},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T123","span":{"begin":472,"end":477},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T124","span":{"begin":587,"end":596},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T125","span":{"begin":629,"end":633},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T115","span":{"begin":6,"end":14},"obj":"Chemical"},{"id":"T116","span":{"begin":109,"end":114},"obj":"Chemical"},{"id":"T117","span":{"begin":160,"end":167},"obj":"Chemical"},{"id":"T118","span":{"begin":321,"end":323},"obj":"Chemical"},{"id":"T120","span":{"begin":362,"end":364},"obj":"Chemical"},{"id":"T121","span":{"begin":494,"end":502},"obj":"Chemical"},{"id":"T122","span":{"begin":539,"end":543},"obj":"Chemical"},{"id":"T123","span":{"begin":574,"end":581},"obj":"Chemical"}],"attributes":[{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_37409"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_53550"},{"id":"A119","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_73646"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":201,"end":220},"obj":"http://purl.obolibrary.org/obo/GO_0044409"},{"id":"T23","span":{"begin":587,"end":616},"obj":"http://purl.obolibrary.org/obo/GO_0002253"},{"id":"T24","span":{"begin":601,"end":616},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T89","span":{"begin":0,"end":649},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]"}