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PMC:7073332 / 7170-8507 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
173 215-220 Species denotes human Tax:9606
174 236-253 Species denotes Human coronavirus Tax:694448
175 520-525 Species denotes human Tax:9606
176 884-889 Species denotes human Tax:9606
177 1093-1098 Species denotes human Tax:9606
178 1319-1324 Species denotes human Tax:9606
179 255-259 Species denotes HCoV Tax:694448
180 347-351 Species denotes HCoV Tax:694448
181 417-421 Species denotes HCoV Tax:694448
182 821-825 Species denotes HCoV Tax:694448
183 1246-1255 Disease denotes infection MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T22 277-285 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T23 352-359 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 433-441 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T25 526-533 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 558-562 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T27 974-982 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 1129-1137 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 1272-1279 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 1280-1287 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T28 1246-1255 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T45 71-72 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 168-173 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47 215-220 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T48 234-235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 236-241 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T50 341-342 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 343-346 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T52 372-373 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T53 520-533 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T54 558-562 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T55 884-889 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56 1093-1098 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T57 1169-1170 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 1319-1324 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T71 108-116 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T72 195-199 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T73 221-224 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T75 277-285 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T76 352-359 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 400-404 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T78 433-441 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 494-499 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T80 526-533 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 688-692 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T82 802-807 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T83 974-982 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T84 1129-1137 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T85 1152-1156 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T86 1209-1213 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T87 1236-1245 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T88 1272-1279 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 1280-1287 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T41 32-1337 Sentence denotes Our network-based methodology combines a systems pharmacology-based network medicine platform that quantifies the interplay between the virus–host interactome and drug targets in the human PPI network. a Human coronavirus (HCoV)-associated host proteins were collected from literatures and pooled to generate a pan-HCoV protein subnetwork. b Network proximity between drug targets and HCoV-associated proteins was calculated to screen for candidate repurposable drugs for HCoVs under the human protein interactome model. c, d Gene set enrichment analysis was utilized to validate the network-based prediction. e Top candidates were further prioritized for drug combinations using network-based method captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. f Overall hypothesis of the network-based methodology: (i) the proteins that functionally associate with HCoVs are localized in the corresponding subnetwork within the comprehensive human interactome network; and (ii) proteins that serve as drug targets for a specific disease may also be suitable drug targets for potential antiviral infection owing to common protein–protein interactions elucidated by the human interactome.