PMC:7073332 / 28199-29388
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
792 | 55-64 | Species | denotes | 2019-nCoV | Tax:2697049 |
793 | 65-75 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
803 | 909-926 | Gene | denotes | estrogen receptor | Gene:2099 |
804 | 463-476 | Gene | denotes | Drugs A and B | |
805 | 368-373 | Species | denotes | human | Tax:9606 |
806 | 113-117 | Species | denotes | HCoV | Tax:694448 |
807 | 305-309 | Species | denotes | HCoV | Tax:694448 |
808 | 493-497 | Species | denotes | HCoV | Tax:694448 |
809 | 846-852 | Disease | denotes | tumors | MESH:D009369 |
810 | 993-1010 | Disease | denotes | polycystic kidney | MESH:D007690 |
811 | 1070-1092 | Disease | denotes | rhythm sleep disorders | MESH:D012893 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T140 | 129-136 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T141 | 797-800 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T142 | 909-917 | Body_part | denotes | estrogen | http://purl.org/sig/ont/fma/fma83376 |
T143 | 1004-1010 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
T144 | 1019-1028 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T145 | 1032-1046 | Body_part | denotes | biogenic amine | http://purl.org/sig/ont/fma/fma67161 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T7 | 1004-1010 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T121 | 65-73 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T122 | 846-852 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
T123 | 1060-1092 | Disease | denotes | circadian rhythm sleep disorders | http://purl.obolibrary.org/obo/MONDO_0024361 |
T124 | 1077-1092 | Disease | denotes | sleep disorders | http://purl.obolibrary.org/obo/MONDO_0003406 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T205 | 77-78 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T206 | 368-373 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T207 | 469-470 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T208 | 475-476 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T209 | 482-483 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T210 | 580-581 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T211 | 591-595 | http://purl.obolibrary.org/obo/CLO_0001869 | denotes | B. b |
T212 | 683-684 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T213 | 696-697 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T214 | 909-926 | http://purl.obolibrary.org/obo/PR_000007204 | denotes | estrogen receptor |
T215 | 1004-1010 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
T216 | 1004-1010 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
T217 | 1004-1010 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
T218 | 1030-1031 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T313 | 33-37 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T314 | 129-136 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T315 | 160-164 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T316 | 192-196 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T317 | 286-291 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T318 | 664-668 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T319 | 685-694 | Chemical | denotes | sirolimus | http://purl.obolibrary.org/obo/CHEBI_9168 |
T320 | 705-722 | Chemical | denotes | immunosuppressant | http://purl.obolibrary.org/obo/CHEBI_35705 |
T321 | 733-743 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
T322 | 748-762 | Chemical | denotes | antineoplastic | http://purl.obolibrary.org/obo/CHEBI_35610 |
T323 | 811-820 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T324 | 857-867 | Chemical | denotes | toremifene | http://purl.obolibrary.org/obo/CHEBI_9635 |
T325 | 909-936 | Chemical | denotes | estrogen receptor modulator | http://purl.obolibrary.org/obo/CHEBI_50739 |
T326 | 909-917 | Chemical | denotes | estrogen | http://purl.obolibrary.org/obo/CHEBI_50114 |
T327 | 918-936 | Chemical | denotes | receptor modulator | http://purl.obolibrary.org/obo/CHEBI_90710 |
T328 | 943-949 | Chemical | denotes | emodin | http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659 |
T330 | 967-971 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T331 | 1019-1028 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T332 | 1041-1046 | Chemical | denotes | amine | http://purl.obolibrary.org/obo/CHEBI_32952 |
T333 | 1099-1113 | Chemical | denotes | mercaptopurine | http://purl.obolibrary.org/obo/CHEBI_50667 |
T334 | 1118-1132 | Chemical | denotes | antimetabolite | http://purl.obolibrary.org/obo/CHEBI_35221 |
T335 | 1133-1153 | Chemical | denotes | antineoplastic agent | http://purl.obolibrary.org/obo/CHEBI_35610 |
T336 | 1159-1176 | Chemical | denotes | immunosuppressant | http://purl.obolibrary.org/obo/CHEBI_35705 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T39 | 797-810 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
T40 | 801-810 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T41 | 1060-1076 | http://purl.obolibrary.org/obo/GO_0007623 | denotes | circadian rhythm |
T42 | 1070-1076 | http://purl.obolibrary.org/obo/GO_0048511 | denotes | rhythm |
T43 | 1077-1082 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T21 | 993-1010 | Phenotype | denotes | polycystic kidney | http://purl.obolibrary.org/obo/HP_0000113 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T173 | 77-178 | Sentence | denotes | a The possible exposure mode of the HCoV-associated protein module to the pairwise drug combinations. |
T174 | 179-394 | Sentence | denotes | An effective drug combination will be captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. |
T175 | 395-498 | Sentence | denotes | ZCA and ZCB denote the network proximity (Z-score) between targets (Drugs A and B) and a specific HCoV. |
T176 | 499-1189 | Sentence | denotes | SAB denotes separation score (see Materials and methods) of targets between Drug A and Drug B. b–d Inferred mechanism-of-action networks for three selected pairwise drug combinations: b sirolimus (a potent immunosuppressant with both antifungal and antineoplastic properties) plus dactinomycin (an RNA synthesis inhibitor for treatment of various tumors), c toremifene (first-generation nonsteroidal-selective estrogen receptor modulator) plus emodin (an experimental drug for the treatment of polycystic kidney), and d melatonin (a biogenic amine for treating circadian rhythm sleep disorders) plus mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties). |